Mindfulness-based Stress Reduction (MBSR) and Its Effects on Psychoimmunological Factors of Chemically Pulmonary Injured Veterans
-
Zahra Arefnasab
,
Abdolreza Babamahmoodi
,
Farhang Babamahmoodi
,
Ahmad Ali Noorbala
,
Ahmad Alipour
,
Yunes Panahi
,
Jamal Shams
,
Farhad Riazi Rad
,
Vahid Khaze
,
Mostafa Ghanei
Abstract
Mindfulness-based Stress Reduction (MBSR) is a treatment program for relieving stress and coping with chronic illnesses. In recent three decades, studies have shown that MBSR has a positive effect on physical and psychological dimensions of chronic illnesses. Chemically pulmonary injured veterans have chronic pulmonary and psychological problems due to mustard gas exposure and complications of Iran-Iraq war. These stresses have negative effects on their general health and immune system. To the best of our knowledge, this is the first study conducted on psychoneuroimmunology and MBSR in these patients. Forty male pulmonary injured veterans were randomly divided in two groups with 20 participants (MBSR and wait-list control). Then MBSR group received 8 weekly sessions of intervention. We tested mental health based on general health questionnaire (GHQ)-28 questionnaire, health-related quality of life (based on St. George respiratory questionnaire (SGRQ) ) and immunity in MBSR groups; before and after intervention "mixed factorial analyses of variance" test was used for analyzing data fpr each dependent variable and appropriate t-tests were done in The necessary condition. Results showed that mental health and health- related quality of life, in MBSR group compared to wait-list control improved [F (1,38)=26.46, p<0.001; F (1,38)=49.52, p<0.001 respectively] significantly. Moreover, a significant increase was reported in the lymphocyte proliferation with phytohemagglutinin (PHA) [F (1,38)=16.24, p<0.001], and peripheral blood IL-17 [F (1,38)=56.71, p<0.001] However, lymphocyte (CD4+, CD8+, and NK-cell) percentages were not affected significantly [F (1,38)=2.21, p=0.14] ,[F (1,38)=0.90, p=0.78] and [F (1,38)=1.79, p=0.18], respectively. This study suggests that MBSR may be a new treatment approach for improving immunity and overall health in chemically pulmonary injured veterans.
1- Weber, B., Jermann, F., Lutz, A., Bizzini, L., & Bondolfi, G. Mindfulness-based therapeutic approaches: benefits for individuals suffering from pain. Rev Med Suisse, 2012.Jun 27, 8(347), 1395-8 [Article in French ].
2- Edenfield, T.M., & Saeed, S.A. An update on mindfulness meditation as a self-help treatment for anxiety and depression. Psychol Res Behav Manag. 2012, 5, 131-41.
3- Goleman, D.J., & Schwartz, G.E. 1976. Meditation as an intervention in stress reactivity. J Consult Clin Psychol, 44, 456–466. [PubMed]
4- Kabat-Zinn, J. 1982. An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. Gen Hosp Psychiatry, 4,33–47 [PubMed]
5- Kabat-Zinn, J. 2003. Mindfulness-based interventions in context: past, present, and future. Clin Psychol (New York), 10(2), 144–156.
6- Henderson, V.P., Massion, A.O., Clemow, L., Hurley, T.G., Druker, S., & Hébert, J.R. 2013. A Randomized Controlled Trial of Mindfulness-Based Stress Reduction for Women with Early-Stage Breast Cancer Receiving Radiotherapy. ntegr Cancer Ther. Jan 28. [Epub ahead of print]
7- Fjorback , L. O., Arendt, M., Ornbøl, E., Walach, H., Rehfeld, E., Schröder, A., & Fink, P. 2013. Mindfulness therapy for somatization disorder and functional somatic syndromes: randomized trial with one-year follow-up. J Psychosom Res, 74(1), 31-40.
8- Gallegos, A. M., Hoerger, M., Talbot, N. L., Krasner, M. S., Knight, J. M., Moynihan, J. A., & Duberstein, P.R. 2013. Toward Identifying the Effects of the Specific Components of Mindfulness-Based Stress Reduction on Biologic and Emotional Outcomes Among Older Adults. J Altern Complement, Med. Feb 5. [Epub ahead of print].
9- Arch, J. J., Ayers, C. R., Baker, A., Almklov, E., Dean, D. J., & Craske, M. G. 2013. Randomized clinical trial of adapted mindfulness-based stress reduction versus group cognitive behavioral therapy for heterogeneous anxiety disorders. Behav Res Ther, 51(4-5), 185-196.
10- Würtzen, H., Dalton, S. O., Elsass, P., Sumbundu, A. D., Steding-Jensen, M., Karlsen, R. V. ... & Johansen, C. 2012. Mindfulness significantly reduces self-reported levels of anxiety and depression: Results of a randomised controlled trial among 336 Danish women treated for stage I-III breast cancer. Eur J Cancer, 19 [Epub ahead of print]
11- Zainal, N. Z., Booth, S., & Huppert, F.A. 2012.The efficacy of mindfulness-based stress reduction on mental health of breast cancer patients: a meta-analysis. Psychooncology, 7 [Epub ahead of print]
12- Hazlett-Stevens, H. 2012. Mindfulness-based stress reduction for comorbid anxiety and depression: case report and clinical considerations. J Nerv Ment Dis, 200(11), 999-1003.
13- Nyklíček, I., Dijksman, S. C., Lenders, P. J., Fonteijn, W. A., Koolen, J. J.A. 2012. Brief mindfulness based intervention for increase in emotional well-being and quality of life in percutaneous coronary intervention (PCI) patients: the MindfulHeart randomized controlled trial. J Behav Med, 23. [Epub ahead of print]
14- Asmaee, M. S., Seghatoleslam, T., Homan, H., Akhvast, A., & Habil, H. 2012. Effect of mindfulness based stress management on reduction of generalized anxiety disorder. Iran J Public Health, 41(10), 24-8.
15- Jam, S., Imani, A.H., Foroughi, M., SeyedAlinaghi, S.A., Emadi Koochak, H., & Mohraz, M., 2010. The Effects of Mindfulness-Based Stress Reduction (MBSR) Program in Iranian HIV/AIDS Patients: A Pilot Study. Acta Medica Iranica, 48(2), 101-106.
16- Martín-Asuero, A., García-Banda, G. 2010. The Mindfulness-Based Stress Reduction Program (MBSR) Reduces Stress-Related Psychological Distress in Healthcare Professionals. The Spanish Journal of Psychology, 13(2), 897-905.
17- Rosenzweig, S., Reibel, D. K., Greeson, J. M., Edman, J. S., Jasser, S. A., McMearty, K. D., & Goldstein, B. J. 2007. Mindfulness-based stress reduction is associated with improved glycemic control in type 2 diabetes mellitus: pilot study alternative therapies. Altern Ther Health Med, 13(5), 36-8.
18- Speca, M., Carlson, L. E., & Goodey, E., & Angen, M. 2000. A Randomized, Wait-List Controlled Clinical Trial: The Effect of Mindfulness Meditation-Based Stress Reduction Program on Mood and Symptoms of Stress in Cancer Outpatients. Psychosomatic Medicine, 62,613–622.
19- Cohen-Katz, J., Wiley, S. D., Capuano, T., Baker, D. M, & Shapiro, S. 2005.The Effects of Mindfulness-based Stress Reduction on Nurse Stress and Burnout, Part II. Holistic Nursing Practice, January/February, 26-35.
20- Carlson, L.E., Speca, M., Patel, K. D., Goodey, E. 2004. Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients. Psychoneuroendocrinology, 29(4), 448-74.
21. Rosenzweig S, Reibel DK, Greeson JM, Brainard GC, Hojat M.Mindfulness-based stress reduction lowers psychological distress in medical students. Teach Learn Med. 2003 Spring;15(2):88-92.Zeller JM, Levin PF. Mindfulness interventions to reduce stress among nursing personnel: an occupational health perspective. Workplace Health Saf 2013; 61(2):85-9.
22. Carlson LE, Speca M, Faris P, Patel KD. One year pre- post intervention follow-up of psychological, immune, endocrine and blood pressure outcomes of mindfulness- based stress reduction (MBSR) in breast and prostate cancer outpatients. Brain Behav Immun 2007;21(8):1038-49.
23. Witek-Janusek L, Albuquerque K, Chroniak KR, Chroniak C, Durazo-Arvizu R, Mathews HL. Effect of mindfulness based stress reduction on immune function, quality of life and coping in women newly diagnosed with early stage breast cancer. Brain Behav Immun 2008;22(6):969-81.
24. Lengacher CA, Kip KE, Post-White J, Fitzgerald S, Newton C, Barta M, et al. Lymphocyte recovery after breast cancer treatment and mindfulness-based stress reduction (MBSR) therapy. Biol Res Nurs 2013;15(1):37-47.
25. Creswell JD, Myers HF, Cole SW, Irwin MR.Mindfulness meditation training effects on CD4+ T lymphocytes in HIV-1 infected adults: a small randomized controlled trial. Brain Behav Immun 2009;23(2):184-8.
26. Jovanovic DV, Di Battista JA, Martel-Pelletier J, Jolicoeur FC, He Y, Zhang M, et al. IL-17 Stimulates theProduction and Expression of Proinflammatory Cytokines, IL-b and TNF-a, by Human Macrophages. J Immunol 1998; 160(7):3513–21.
27. Zhang L, Li K, Bing Ma L, Gong SB, Wang GY, Liu Y, et al. Effects and mechanism of arsenic trioxide on reversing the asthma pathologies including Th17-IL-17 axis in a mouse model. Iran J Allergy Asthma Immunol2012; 11(2):133-45.
28. Robinson FP, Mathews HL, Witek-Janusek L. Psycho- endocrine-immune response to mindfulness-based stress reduction in individuals infected with the human immunodeficiency virus: a quasiexperimental study. J Altern Complement Med 2003; 9(5):683-94.
29. Gaffen S. IL-17 receptor composition. Nat Rev Immunol2016; 16(1):4.
30. Sterling M. General Health Questionnaire - 28 (GHQ-28).J Physiother 2011; 57(4):259.
31. Ferrer M, Alonso J, Prieto L, Plaza V, Monsó E, Marrades R, et al. Validity and reliability of the St George's Respiratory Questionnaire after adaptation to a different language and culture: the Spanish example. Eur Respir J 1996; 9(6):1160-6.
32. Vedhara, Kav; Irwin, Michael, 1954-.Human psychoneuroimmunology -Oxford ; New York : Oxford University Press, 2005. NLM ID: 101249230 [Book]
33. Link JS, Barker T, Serpa S, Pinjala M, Oswald T, Lashley LK. Mild Traumatic Brain Injury and Mindfulness-Based Stress Reduction: A Review. Archives of Assessment Psychology 2016; 6(1):7-32.
34. O'Malley PG. In veterans with PTSD, mindfulness-based group therapy reduced symptom severity. Ann Intern Med 2015; 163(12):JC9.
35. King AP, Block SR, Sripada RK, Rauch S, Giardino N, Favorite T, et al. Altered Default Mode Network (DMN) Resting State Functional Connectivity Following A Mindfulness-Based Exposure Therapy For Posttraumatic Stress Disorder (PTSD) In Combat Veterans Of Afghanistan And Iraq. Depress Anxiety 2016; 33(4):289-99.
36. Kearney DJ, McDermott K, Malte C, Martinez M, Simpson TL. Association of Participation in a Mindfulness Program with Measures of PTSD, Depression and Quality of Life in a Veteran Sample. J Clin Psychol 2012; 68(1):101-6.
37. Zainal NZ1, Booth S, Huppert FA. The efficacy ofmindfulness-based stress reduction on mental health of breast cancer patients: a meta-analysis. Psychooncology2013; 22(7):1457-65.
38. Kabat-Zinn J, Massion AO, Kristeller J, Peterson LG,Fletcher KE, Pbert L, et al. Effectiveness of a Meditation- Based Stress Reduction Program in the Treatment of Anxiety Disorders. Am J Psychiatry 1992; 149(7):936-42.
39. Carlson LE, Speca M, Patel KD, Goodey E. Mindfulness- based stress reduction in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients. Psychosom Med 2003;65(4):571-81.
40. Chiesa A, Serretti A. Mindfulness-Based Stress Reduction for Stress Management in Healthy People: A Review and Meta-Analysis. J Altern Complement Med15(5):593–600
41. Creswell JD, Myers HF, Cole SW, Irwin MR.Mindfulness meditation training effects on CD4+ T lymphocytes in HIV-1 infected adults: a small randomized controlled trial. Brain Behav Immun 2009;23(2):184-8.
42. Coronado-Montoya S, Levis AW, Kwakkenbos L, Steele RJ, Turner EH, Thombs BD. Reporting of Positive Results in Randomized Controlled Trials of Mindfulness- Based Mental Health Interventions. PloS one 2016;11(4):e0153220.
| Files | ||
| Issue | Vol 15, No 6 (2016) | |
| Section | Original Article(s) | |
| Keywords | ||
| CD4 CD8 IL-17 Lymphocyte proliferation Mindfulness Mental health NK-cell Quality of life Veterans | ||
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