Association between Peptidylarginine Deiminase Type 4 rs1748033 Polymorphism and Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran
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Abstract
There are controversial reports regarding the role of peptidylarginine deiminase type 4 (PADI4) gene polymorphisms and risk of Rheumatoid arthritis (RA). The aim of the present study was to investigate the impact of PADI4 rs1748033 polymorphism and susceptibility to RA in a sample of the Iranian population.This case-control study was done on 150 patients with RA and 150 healthy subjects.PADI4 rs1748033 genotyping was done using amplification refractory mutation system- polymerase chain reaction (ARMS-PCR) assay.The PADI4 rs1748033 variant increased the risk of RA in codominant (OR=1.67,95%CI=1.03-2.71, p=0.048, CT vs CC; OR=2.73, 95%CI=1.25-5.97, p=0.013, TT vs CC) and dominant (OR=1.84, 95%CI=1.15-2.92, p=0.014, CT+TT vs CC) tested inheritance models. In addition, the PADI4 rs1748033 T allele increased the risk of RA (OR=1.63,95%CI=1.16-2.29, p=0.006) in comparison with C allele.In conclusion, our finding indicated that PADI4 rs1748033 gene polymorphism increased the risk of RA in a sample of the Iranian population.
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| Issue | Vol 14, No 3 (2015) | |
| Section | Original Article(s) | |
| Keywords | ||
| PADI4 Polymorphism Rheumatoid arthritis | ||
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