Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 14 3 2015 10 18 255 260 EN Mohammad Hashemi Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran AND Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Zahra Zakeri Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran AND Department of Internal Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hamed Taheri Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Gholamreza Bahari Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Mohsen Taheri Genetics of Non Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran 2015 10 18 2015 10 18 There are controversial reports regarding the role of peptidylarginine deiminase type 4 (PADI4) gene polymorphisms and risk of Rheumatoid arthritis (RA). The aim of the present study was to investigate the impact of PADI4 rs1748033 polymorphism and susceptibility to RA in a sample of the Iranian population.This case-control study was done on 150 patients with RA and 150 healthy subjects.PADI4 rs1748033 genotyping was done using amplification refractory mutation system- polymerase chain reaction (ARMS-PCR) assay.The  PADI4  rs1748033  variant  increased  the  risk  of  RA  in  codominant  (OR=1.67,95%CI=1.03-2.71, p=0.048, CT vs CC; OR=2.73, 95%CI=1.25-5.97, p=0.013, TT vs CC) and dominant (OR=1.84, 95%CI=1.15-2.92, p=0.014, CT+TT vs CC) tested inheritance models. In addition, the PADI4 rs1748033 T allele increased the risk of RA (OR=1.63,95%CI=1.16-2.29, p=0.006) in comparison with C allele.In conclusion, our finding indicated that PADI4 rs1748033 gene polymorphism increased the risk of RA in a sample of the Iranian population. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/565 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/565/450