Genetic Polymorphisms in Matrix Metalloproteinases -1 and -7 and Susceptibility to Gastric Cancer: an Association Study and Meta-Analysis
Abstract
Matrix Metalloproteinases (MMPs) play an important role in gastric cancer (GC). Accumulated evidence suggests that functional MMP-1 and MMP-7 gene polymorphisms are associated with several tumors. The aim of this study was to investigate two single nucleotide polymorphisms, MMP-1 -1607 1G/2G and MMP-7 -181 A/G, and their potential relationship with GC.
We examined 246 GC patients and 252 age-and sex-matched controls from Sichuan province in China. Genotypes were determined using a polymerase chain reaction-restriction fragment length polymorphism strategy and DNA sequencing. We also performed a meta- analysis of relevant studies, involving 1084 cases and 1721 controls, to place our findings in a broader context.
No significant relationship was observed between the MMP-1 -1607 1G/2G alleles and genotypes and the risk of GC. There were significant differences in the genotypes and allele distributions of the -181 A/G polymorphism of the MMP-7 gene between cases and controls. The -181 A allele carriers had a significantly increased risk of GC compared with 181 G allele carriers (OR=3.051, 95% CI, 1.475-6.310, P=0.002), and the AA genotype of 181 A/G was associated with an increased risk of GC compared with the AG genotype (OR=3.189, 95% CI, 1.523-6.676, P=0.001).
A meta-analysis of six studies also showed a significant risk of GC associated with MMP-7 polymorphism.
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| Issue | Vol 12, No 3 (2013) | |
| Section | Articles | |
| Keywords | ||
| Gastric cancer Matrix metalloproteinases Meta-analysis Polymorphism Single Nucleotide | ||
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