Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 12 3 2013 09 15 203 210 EN Wen-Liang Fang Central Laboratory of Clinical College, Anhui Medical University, Hefei 230601, P. R. China AND Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, P. R. China Wei-Bo Liang Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, P. R. China Lin-Bo Gao Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, P. R. China Bin Zhou Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, P. R. China Feng-Li Xiao Central Laboratory of Clinical College, Anhui Medical University, Hefei 230601, P. R. China Lin Zhang Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, P. R. China AND Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, P. R. China 2015 10 16 Matrix Metalloproteinases (MMPs) play an important role in gastric cancer (GC). Accumulated evidence suggests that functional MMP-1 and MMP-7 gene polymorphisms are associated with several tumors. The aim of this study was to investigate two single nucleotide polymorphisms, MMP-1 -1607 1G/2G and MMP-7 -181 A/G, and their potential relationship with GC. We examined 246 GC  patients and 252 age-and sex-matched controls  from  Sichuan province in China. Genotypes were determined using a polymerase chain reaction-restriction fragment length polymorphism strategy and DNA sequencing. We also performed a meta- analysis of relevant studies, involving 1084 cases and 1721 controls, to place our findings in a broader context. No significant relationship was observed between the MMP-1 -1607 1G/2G alleles and genotypes and the risk of GC. There were significant differences in the genotypes and allele distributions  of  the  -181 A/G  polymorphism  of  the  MMP-7 gene between  cases and controls. The -181 A allele carriers had a significantly increased risk of GC compared with 181 G allele carriers (OR=3.051, 95% CI, 1.475-6.310, P=0.002), and the AA genotype of 181 A/G  was associated with an increased risk of GC compared with the AG genotype (OR=3.189, 95% CI, 1.523-6.676, P=0.001). A meta-analysis of six studies also showed a significant risk of GC associated with MMP-7 polymorphism. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/511 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/511/527