Gastroesophageal Reflux Disease and Asthma in Pregnant Women with Dyspnea
-
Katayoon Bidad
,
Hassan Heidarnazhad
,
Zahra Pourpak
,
Giti Shayestefar
,
Heshmat Moayeri
,
Nasrin Zendehdel
Abstract
Asthma and gastroesophageal reflux disease (GERD) are two common problems in pregnancy and they affect pregnancy in several ways. In this study, we aimed to evaluate GERD and asthma in pregnant women who referred for prenatal care visits.
One-hundred and seventy three pregnant women with a complaint of dyspnea were included in the study. A questionnaire was filled and lung function tests were performed. All patients were visited by a respiratory specialist and questionnaires were evaluated by a gastroenterologist.
Out of the total number of women studied, 37% were diagnosed to have asthma and 36.4% were non-asthmatics. Twenty six percent of the pregnant women who had symptoms and signs of asthma with normal spirometry were classified as probable to have asthma. GERD was diagnosed in 80.9% of the pregnant women, but it was not significantly higher in asthmatic or probable asthmatic women compared to non-asthmatic ones. However, severity of GERD was significantly higher in asthmatic pregnant women compared to the others.
In conclusion, the prevalence of GERD was quite high in pregnant women, irrespective of the fact that they were asthmatic or non-asthmatic. Further studies evaluating women throughout pregnancy will inform us more about this relationship.
1. Valle C, Broglia F, Pistorio A, Tinelli C, Perego M.Prevalence and impact of symptoms suggestive of gastroesophageal reflux disease. Dig Dis Sci 1999;44(9):1848-52.
2. Theodoropoulos DS, Lockey RF, Boyce HW Jr, Bukantz SC. Gastroesophageal reflux and asthma: a review of pathogenesis, diagnosis, and therapy. Allergy 1999;54(7):651-61.
3. Ehsani MJ, Maleki I, Mohammadzadeh F, Mashayekh A.Epidemiology of gastroesophageal reflux disease in Tehran, Iran. J Gastroenterol Hepatol 2007; 22(9):1419-22.
4. Nouraie M, Razjouyan H, Assady M, Malekzadeh R, Nasseri-Moghaddam S. Epidemiology of gastroesophageal reflux symptoms in Tehran, Iran: a population-based telephone survey. Arch Iran Med 2007;10(3):289-94.
5. Charan M, Katz PO. Gastroesophageal Reflux Disease in Pregnancy. Curr Treat Options Gastroenterol 2001;4(1):73-81.
6. Petronella SA, Conboy-Ellis K. Asthma epidemiology: risk factors, case finding, and the role of asthma coalitions. Nurs Clin North Am 2003; 38(4):725-35.
7. Gluck, JC. The Change of asthma Course During Pregnancy. Clinical Reviews in Allergy & Immunology 2004; 26(3):171-180.
8. Namazy JA, Schatz M. Asthma and pregnancy. J Allergy Clin Immunol 2011; 128(6):1384-5.
9. Bidad K, Heidarnazhad H, Pourpak Z, Ramazanzadeh F, Zendehdel N, Moin M. Frequency of asthma as the cause of dyspnea in pregnancy. Int J Gynaecol Obstet 2010; 111(2):140-3.
10. Nasseri-Moghaddam S, Razjouyan H, Habibi R, Rafaatzand K, Ahrari B, Nouraie M, et al. Reliability, Validity, and Feasibility of the Mayo Gastro-Esophageal Reflux Questionnaire (GERQ) in a Persian-Speaking Population. Iranian J Publ Health 2008; 37(2):64-74.
11. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J 2005; 26(2):319-38.
12. Klauser AG, Schindlbeck NE, Müller-Lissner SA.Symptoms in gastro-oesophageal reflux disease. Lancet 1990; 335(8683):205-8.
13. Dombrowski MP, Schatz M, Wise R, Momirova V, Landon M, Mabie W, et al. Asthma during pregnancy. Obstet Gynecol 2004; 103(1):5-12.
14. Gluck JC. The change of asthma course during pregnancy. Clin Rev Allergy Immunol 2004; 26(3):171-80.
15. Benninger C, McCallister J. Asthma in pregnancy:reading between the lines. Nurse Pract 2010; 35(4):10-9.
16. Harding SM, Richter JE. The role of gastroesophageal reflux in chronic cough and asthma. Chest 1997;111(5):1389-402.
17. Ramu B, Mohan P, Rajasekaran MS, Jayanthi V.Prevalence and risk factors for gastroesophageal reflux in pregnancy. Indian J Gastroenterol 2011; 30(3):144-7.
18. Rey E, Rodríguez-Artalejo F, Herraiz MA, Alvarez- Sánchez A, Escudero M, Díaz-Rubio M. Atypical symptoms of gastro-esophageal reflux during pregnancy. Rev Esp Enferm Dig 2011; 103(3):129-32.
19. Rey E, Rodriguez-Artalejo F, Herraiz MA, Sanchez P, Alvarez-Sanchez A, Escudero M, et al. Gastroesophageal reflux symptoms during and after pregnancy: a longitudinal study. Am J Gastroenterol 2007;102(11):2395-400.
20. Bor S, Kitapcioglu G, Solak ZA, Ertilav M, Erdinc M.Prevalence of gastroesophageal reflux disease in patients with asthma and chronic obstructive pulmonary disease. J Gastroenterol Hepatol 2010; 25(2):309-13.
21. Chunlertrith K, Boonsawat W, Zaeoue U. Prevalence of gastroesophageal reflux symptoms in asthma patients at Srinagarind Hospital. J Med Assoc Thai 2005; 88(5):668-71.
22. Bor S, Kitapcioglu G, Dettmar P, Baxter T. Association of heartburn during pregnancy with the risk of gastroesophageal reflux disease. Clin Gastroenterol Hepatol 2007; 5(9):1035-9.
23. Malfertheiner P, Nocon M, Vieth M, Stolte M, Jaspersen D, Koelz HR, et al. Evolution of gastro-oesophageal reflux disease over 5 years under routine medical care-- the ProGERD study. Aliment Pharmacol Ther 2012; 35(1):154-64.
24. Richter JE. Gastroesophageal reflux disease during pregnancy. Gastroenterol Clin North Am 2003;32(1):235-61.
| Files | ||
| Issue | Vol 13, No 2 (2014) | |
| Section | Articles | |
| Keywords | ||
| Asthma Dyspnea Gastroesophageal Reflux Pregnancy | ||
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