Phenobarbital-Induced DRESS: A Lichenoïd Picture
-
Amel Chaabane
,
Najah Ben Fadhel
,
Zohra Chadli
,
Nadia Ben Fredj
,
Naceur A Boughattas
,
Karim Aouam
Abstract
We describe, the first case of phenobarbital-induced DRESS syndrome presenting as a lichenoïd eruption. A 49-year-old man had received phenobarbital for a cerebral metastasis. Twenty-five days later, he developed a purplish skin eruption, odynophagia, oral mucosal erosion and fever. Physical examination revealed a cervical lymphadenopathy and facial edema associated to a diffuse violaceous maculo-papular itchy rash. Laboratory findings showed a 1200/mm³ eosinophil's cell count. Alanine aminotransferase was 169 IU/l. Lactate dehydrogenase and creatinine phosphokinase were at 768 and 90 IU/l, respectively. All symptoms resolved completely five weeks after phenobarbital withdrawal. Few days later, the patient died because of a cardio-respiratory arrest.
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| Files | ||
| Issue | Vol 13, No 6 (2014) | |
| Section | Articles | |
| Keywords | ||
| DRESS Lichenoïd eruption Phenobarbital | ||
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