Regulatory Effects of Long Non-coding RNAs on Th17/Treg Differentiation and Imbalance
-
Reza Dabbaghipour
,
Elham Ahmadi
,
Mona Entezam
,
Omid Rahbar Farzam
,
Amir Baghbanzadeh
,
Ali Saber Sichani
,
Nazila Jalilzadeh
,
Mahdi Jafarlou
,
Behzad Baradaran
Abstract
Scientific research over the past decades has proven the pivotal role of long non-coding RNAs (LncRNAs) in regulating gene expression. The immune responses are controlled through the interaction of pro-inflammatory (predominance of T helper 17 cells (Th17)) and anti-inflammatory cytokines excretion (predominance of Regulatory T cells (Treg)). Recent studies have marked the impact of many diverse LncRNAs on Treg/Th17 imbalances. Moreover, some of the roots and causes of human diseases can be associated with the alterations in the Th17/Treg ratio. In this review study, we overviewed the association between LncRNAs and Th17/Treg, with the potential of providing novel prognostic and diagnostic biomarkers and promising therapeutic targets in various diseases, particularly cancer.
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| Files | ||
| Issue | Vol 22 No 6 (2023) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijaai.v22i6.14641 | |
| Keywords | ||
| Long non-coding RNA Regulatory T cells T helper 17 cells | ||
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How to Cite
1.
Dabbaghipour R, Ahmadi E, Entezam M, Rahbar Farzam O, Baghbanzadeh A, Saber Sichani A, Jalilzadeh N, Jafarlou M, Baradaran B. Regulatory Effects of Long Non-coding RNAs on Th17/Treg Differentiation and Imbalance. Iran J Allergy Asthma Immunol. 2023;22(6):512-526.
