The Alleviating Impacts of Quercetin on Inflammation and Oxidant-antioxidant Imbalance in Rats with Allergic Asthma
-
Mohammad Amin Rajizadeh
,
Mohammad Abbas Bejeshk
,
Amir Hossein Doustimotlagh
,
Hamid Najafipour
,
Maryam Eftekhari
,
Merat Mahmoodi
,
Mahdokht Azizi
,
Fahimeh Rostamabadi
,
Hossein Pourghadamyari
Abstract
Asthma is an inflammatory disease of the airways. We assessed the anti-inflammatory and antioxidative impacts of quercetin, a plant derivative, on inflammatory and oxidative indices in lung tissue and serum of rats with asthma.Asth
ma was induced by ovalbumin. Rats were divided into 4 groups: control, asthma+vehicle (Receieved normal saline), asthma+dexamethasone, and asthma+quercetin. After asthma induction, quercetin (50 mg/kg) and dexamethasone (2.5 mg/kg) were injected intraperitoneally once daily for 1 week. On day 50, lung histopathology indices; inflammatory factors; tissue gene expression, including GATA Binding Protein 3 (Gata-3), Tbx21 (T-bet), Transforming growth factor-β (TGF-β), Il10 (IL-10), Il1b (IL-1β), Il6 (IL-6), Acta2 (α-SMA), and Tnf (TNF-α); and oxidative stress indices (malondialdehyde [MDA], catalase [CAT], glutathione peroxidase [GPX], superoxide dismutase [SOD], and total antioxidant capacity [TAC]) in tissue and serum, were evaluated.
The results showed that quercetin reduced Gata3, Tnf, Tgfb1, Il1b, and Acta2 gene expression and increased Tbx21 gene expression following asthma. Quercetin also improved oxidative stress by decreasing MDA levels and increasing TAC, CAT, SOD, and GPX levels in serum and lung tissue. Furthermore, quercetin decreased IL6 and TNFα levels and increased IL10 levels in lung tissue after asthma was treated with quercetin.
Quercetin ameliorates oxidative stress and inflammation caused by asthma, especially at the tissue level. Therefore, quercetin can be considered a potent antiasthmatic agent.
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2. Varmaghani M, Farzadfar F, Sharifi F, Rashidian A, Moin M, Moradi-Lakeh M, et al. Prevalence of asthma, COPD, and chronic bronchitis in Iran: a systematic review and meta-analysis. Iranian J Allergy, Asthma Immunol. 2016:93-104.
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4. Zhang N, Deng C, Zhang X, Zhang J, Bai C. Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice. Asthma Res Practice. 2018;4(1):1-9.
5. Huang W-C, Liu C-Y, Shen S-C, Chen L-C, Yeh K-W, Liu S-H, et al. Protective effects of licochalcone A improve airway hyper-responsiveness and oxidative stress in a mouse model of asthma. Cells. 2019;8(6):617.
6. Denner DR, Doeing DC, Hogarth DK, Dugan K, Naureckas ET, White SR. Airway inflammation after bronchial thermoplasty for severe asthma. Ann American Thoracic Society. 2015;12(9):1302-9.
7. Rajizadeh MA, Najafipour H, Fekr MS, Rostamzadeh F, Jafari E, Bejeshk MA, et al. Anti-inflammatory and antioxidative effects of myrtenol in the rats with allergic asthma. Iran J Pharmaceutical Res. 2019;18(3):1488.
8. Gubernatorova EO, Gorshkova EA, Namakanova OA, Zvartsev RV, Hidalgo J, Drutskaya MS, et al. Non-redundant functions of IL-6 produced by macrophages and dendritic cells in allergic airway inflammation. Front Immunol. 2018;9:2718.
9. Shim HJ, Park S-Y, Kwon H-S, Song W-J, Kim T-B, Moon K-A, et al. Oxidative stress modulates the expression pattern of peroxiredoxin-6 in peripheral blood mononuclear cells of asthmatic patients and bronchial epithelial cells. Allergy Asthma Immunol Res. 2020;12(3):523-36.
10. Laxmi V, Gupta R, Bhattacharya SK, Ray A, Gulati K. Inhibitory effects of sildenafil and tadalafil on inflammation, oxidative stress and nitrosative stress in animal model of bronchial asthma. Pharmacol Rep. 2019;71(3):517-21.
11. Doustimotlagh AH, Dehpour AR, Nourbakhsh M, Golestani A. Alteration in membrane protein, antioxidant status and hexokinase activity in erythrocytes of CCl4-induced cirrhotic rats. Acta Medica Iranica. 2014:795-803.
12. Choo CYW, Yeh K-W, Huang J-L, Su K-W, Tsai M-H, Hua M-C, et al. Oxidative stress is associated with atopic indices in relation to childhood rhinitis and asthma. J Microbiol Immunol Infection. 2021;54(3):466-73.
13. Garavaglia ML, Giustarini D, Colombo G, Reggiani F, Finazzi S, Calatroni M, et al. Blood Thiol Redox State in Chronic Kidney Disease. Int J Mol Sci. 2022;23(5):2853.
14. Rajizadeh MA, Aminizadeh AH, Esmaeilpour K, Bejeshk MA, Sadeghi A, Salimi F. Investigating the effects of Citrullus colocynthis on cognitive performance and anxiety-like behaviors in STZ-induced diabetic rats. Int J Neuroscience. 2021:1-13.
15. Bejeshk MA, Aminizadeh AH, Rajizadeh MA, Khaksari M, Lashkarizadeh M, Shahrokhi N, et al. The effect of combining basil seeds and gum Arabic on the healing process of experimental acetic acid-induced ulcerative colitis in rats. J Traditional Complementary Med. 2022;12(6):599-607.
16. Amirazodi M, Mehrabi A, Rajizadeh MA, Bejeshk MA, Esmaeilpour K, Daryanoosh F, et al. The effects of combined resveratrol and high intensity interval training on the hippocampus in aged male rats: An investigation into some signaling pathways related to mitochondria. Iran J Basic Med Sci. 2022;25(2):254.
17. Anand David AV, Arulmoli R, Parasuraman S. Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid. Pharmacogn Rev. 2016;10(20):84-9.
18. Tang S-M, Deng X-T, Zhou J, Li Q-P, Ge X-X, Miao L. Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects. Biomed Pharmacotherapy. 2020;121:109604.
19. Yang Y-G, Tian W-M, Zhang H, Li M, Shang Y-X. Nerve growth factor exacerbates allergic lung inflammation and airway remodeling in a rat model of chronic asthma. Exp Therapeutic Med. 2013;6(5):1251-8.
20. Bejeshk MA, Pourghadamyari H, Najafipour H, Eftekhari M, Mottaghipisheh J, Omidifar N, et al. The Hydroalcoholic Extract of Nasturtium officinale Reduces Lung Inflammation and Oxidative Stress in an Ovalbumin-Induced Rat Model of Asthma. Evidence-Based Complementary and Alternative Medicine. 2022.
21. Bejeshk MA, Aminizadeh AH, Jafari E, Motamedi S, Zangiabadi I, Ghasemi A, et al. Myrtenol Ameliorates Recognition Memories’ Impairment and Anxiety-Like Behaviors Induced by Asthma by Mitigating Hippocampal Inflammation and Oxidative Stress in Rats. Neuroimmunomodulation. 2023:42-54.
22. Ilić S, Stojiljković N, Veljković M, Veljković S, Stojanović G. Protective effect of quercetin on cisplatin-induced nephrotoxicity in rats. Facta Universitatis Series: Medicine and Biology. 2014;16(2):71-5.
23. Sadeghi H, Azarmehr N, Razmkhah F, Sadeghi H, Danaei N, Omidifar N, et al. The hydroalcoholic extract of watercress attenuates protein oxidation, oxidative stress, and liver damage after bile duct ligation in rats. J Cell Biochem. 2019;120(9):14875-84.
24. Doustimotlagh AH, Kokhdan EP, Vakilpour H, Khalvati B, Barmak MJ, Sadeghi H, et al. Protective effect of Nasturtium officinale R. Br and quercetin against cyclophosphamide-induced hepatotoxicity in rats. Molecular Biol Rep. 2020;47(7):5001-12.
25. Khaldi T, Chekchaki N, Boumendjel M, Taibi F, Abdellaoui M, Messarah M, et al. Ameliorating effects of Nigella sativa oil on aggravation of inflammation, oxidative stress and cytotoxicity induced by smokeless tobacco extract in an allergic asthma model in Wistar rats. Allergologia et Immunopathologia. 2018;46(5):472-81.
26. Bejeshk M, Fekri MS, Najafipour H, Rostamzadeh F, Jafari E, Rajizadeh M, et al. Anti-inflammatory and anti-remodeling effects of myrtenol in the lungs of asthmatic rats: Histopathological and biochemical findings. Allergologia et Immunopathologia. 2019;47(2):185-93.
27. Balestra AC, Sandy CM, Ramalho F, Júnior AAJ, Contini SHT, Crevelin EJ, et al. Aqueous Pyrostegia venusta (Ker Gawl.) Miers extract attenuates allergen-induced asthma in a mouse model via an antioxidant mechanism. J Asthma. 2021;58(6):808-18.
28. Rajizadeh MA, Esmaeilpour K, Motamedy S, Borzadaranb FM, Sheibani V. Cognitive impairments of sleep-deprived ovariectomized (OVX) female rats by voluntary exercise. Basic Clin Neuroscience. 2020;11(5):573.
29. Bejeshk M-A, Joukar S, Shahouzehi B, Asadi-shekari M, Rajizadeh M, Raji-amirhasani A, et al. Combinatorial effect of lower extremity blood flow restriction and low intensity endurance exercise on aorta of old male rats: Histomorphological and molecular approach. Artery Res. 2018;24:22-31.
30. Berry M, Brightling C, Pavord I, Wardlaw AJ. TNF-α in asthma. Curr Opin Pharmacol. 2007;7(3):279-82.
31. Zare D, Rajizadeh MA, Maneshian M, Jonaidi H, Sheibani V, Asadi-Shekaari M, et al. Inhibition of protease-activated receptor 1 (PAR1) ameliorates cognitive performance and synaptic plasticity impairments in animal model of Alzheimer’s diseases. Psychopharmacology. 2021;238(6):1645-56.
32. Brightling C, Berry M, Amrani Y. Targeting TNF-α: a novel therapeutic approach for asthma. J Allergy Clin Immunol. 2008;121(1):5-10.
33. Matera MG, Calzetta L, Cazzola M. TNF-α inhibitors in asthma and COPD: we must not throw the baby out with the bath water. Pulmonary Pharmacol Therapeutics. 2010;23(2):121-8.
34. Rincon M, Irvin CG. Role of IL-6 in asthma and other inflammatory pulmonary diseases. Int J Biol sci. 2012;8(9):1281.
35. Wood LG, Shivappa N, Berthon BS, Gibson PG, Hebert JR. Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma. Clin Exp Allergy. 2015;45(1):177-83.
36. Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, et al. Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. lancet Resp Med. 2016;4(7):574-84.
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| Files | ||
| Issue | Vol 22 No 2 (2023) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijaai.v22i2.12675 | |
| Keywords | ||
| Asthma Inflammation Oxidative stress Quercetin | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Rajizadeh MA, Bejeshk MA, Doustimotlagh AH, Najafipour H, Eftekhari M, Mahmoodi M, Azizi M, Rostamabadi F, Pourghadamyari H. The Alleviating Impacts of Quercetin on Inflammation and Oxidant-antioxidant Imbalance in Rats with Allergic Asthma. Iran J Allergy Asthma Immunol. 2023;22(2):138-149.
