Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 22 2 2023 04 30 138 149 Mohammad Amin Rajizadeh Student Research Committee, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran AND Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran AND Department of Physiology and Pharmacology, Afzalpour Medical Faculty, Kerman University of Medical Sciences, Kerman, Iran Mohammad Abbas Bejeshk Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran AND Department of Physiology and Pharmacology, Afzalpour Medical Faculty, Kerman University of Medical Sciences, Kerman, Iran Amir Hossein Doustimotlagh Department of Clinical Biochemistry, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran AND Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran Hamid Najafipour Department of Physiology and Pharmacology, Afzalpour Medical Faculty, Kerman University of Medical Sciences, Kerman, Iran AND Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran Maryam Eftekhari Department of Genetics, Hormozgan University of Medical Science, Hormozegan, Iran Merat Mahmoodi Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Mahdokht Azizi Department of Pathology, Shahid Beheshti Hospital, Yasuj University of Medical Science, Yasuj, Iran Fahimeh Rostamabadi Department of Medical Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AND Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran Hossein Pourghadamyari Student Research Committee, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran ANDDepartment of Clinical Biochemistry, Afzalipour Medical Faculty, Kerman University of Medical Sciences, Kerman, Iran AND Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran AND Research Center for Hydatid Disease, Kerman University of Medical Sciences, Kerman, Iran 2022 10 01 2023 01 29 Asthma is an inflammatory disease of the airways. We assessed the anti-inflammatory and antioxidative impacts of quercetin, a plant derivative, on inflammatory and oxidative indices in lung tissue and serum of rats with asthma.Asth ma was induced by ovalbumin. Rats were divided into 4 groups: control, asthma+vehicle (Receieved normal saline), asthma+dexamethasone, and asthma+quercetin. After asthma induction, quercetin (50 mg/kg) and dexamethasone (2.5 mg/kg) were injected intraperitoneally once daily for 1 week. On day 50, lung histopathology indices; inflammatory factors; tissue gene expression, including GATA Binding Protein 3 (Gata-3), Tbx21 (T-bet), Transforming growth factor-β (TGF-β), Il10 (IL-10), Il1b (IL-1β), Il6 (IL-6), Acta2 (α-SMA), and Tnf (TNF-α); and oxidative stress indices (malondialdehyde [MDA], catalase [CAT], glutathione peroxidase [GPX], superoxide dismutase [SOD], and total antioxidant capacity [TAC]) in tissue and serum, were evaluated. The results showed that quercetin reduced Gata3, Tnf, Tgfb1, Il1b, and Acta2 gene expression and increased Tbx21 gene expression following asthma. Quercetin also improved oxidative stress by decreasing MDA levels and increasing TAC, CAT, SOD, and GPX levels in serum and lung tissue. Furthermore, quercetin decreased IL6 and TNFα levels and increased IL10 levels in lung tissue after asthma was treated with quercetin. Quercetin ameliorates oxidative stress and inflammation caused by asthma, especially at the tissue level. Therefore, quercetin can be considered a potent antiasthmatic agent. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3668 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/3668/1935