Case Report
 

Occupational Chronic Hand Dermatitis in Hospital Environment Successfully Treated with Dupilumab: A Case Report

Abstract

Duplilumab is approved to treat mild to moderate atopic dermatitis.  It is unclear, however, whether Dupilumab is effective for occupational hand eczema. In this article, we describe a 29-year-old nurse who developed severe hand eczema after working in a hospital for 6 years and received inadequate relief from routine treatment. Duplilumab was administered to the patient with great results.

1. Fregert S. Occupational dermatitis in a 10-year material. Contact Dermatitis. 1975;1(2):96-107.
2. Agner T, Elsner P. Hand eczema: epidemiology, prognosis and prevention. J Eur Acad Dermatol Venereol. 2020;(34 Suppl 1):4-12.
3. Elsner P, Agner T. Hand eczema: treatment. J Eur Acad Dermatol Venereol. 2020;(34 Suppl 1):13-21.
4. Gandhi NA, Bennett BL, Graham NM, Pirozzi G, Stahl N, Yancopoulos GD. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov. 2016;15(1):35-50.
5. Oosterhaven JAF, Schuttelaar MLA. Responsiveness and interpretability of the Hand Eczema Severity Index. British J Dermatol. 2020;182(4):932-9.
6. Stingni L, Lapomarda V, Lisi P. Occupational hand dermatitis in hospital environments. Contact Dermatitis. 1995;33(3):172-6.
7. Molin S, Bauer A, Schnuch A, Geier J. Occupational contact allergy in nurses: results from the Information Network of Departments of Dermatology 2003-2012. Contact Dermatitis. 2015;72(3):164-71.
8. Guertler A, Moellhoff N, Schenck TL, Hagen CS, Kendziora B, Giunta RE, et al. Onset of occupational hand eczema among healthcare workers during the SARS-CoV-2 pandemic: Comparing a single surgical site with a COVID-19 intensive care unit. Contact Dermatitis. 2020;83(2):108-14.
9. Lampel HP, Powell HB. Occupational and Hand Dermatitis: a Practical Approach. Clin Rev in allergy & immunology 2019; 56(1):60-71.
10. Beck LA, Thaçi D, Hamilton JD, Graham NM, Bieber T, Rocklin R, et al. Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis. New England Journal of Medicine 2014; 371(2):130-139.
11. Faiz S, Giovannelli J, Podevin C, Jachiet M, Bouaziz J-D, Reguiai Z, et al. Effectiveness and safety of dupilumab for the treatment of atopic dermatitis in a real-life French multicenter adult cohort. J Am Acad Dermatol; 2019;81(1):143-51.
12. Waldman RA, DeWane ME, Sloan B, Grant-Kels JM, Lu J. Dupilumab for the treatment of dyshidrotic eczema in 15 consecutive patients. J Am Acad Dermatol. 2020;82(5):1251-2.
13. Halling AS, Zachariae C, Thyssen JP. Severe treatment-resistant acute and recurrent vesicular chronic hand eczema successfully treated with dupilumab. Contact Dermatitis. 2020;83(1):37-8.
14. Zirwas MJ. Dupilumab for hand eczema. J Am Acad Dermatol. 2018;79(1):167-9.
Files
IssueVol 21 No 4 (2022) QRcode
SectionCase Report(s)
DOI https://doi.org/10.18502/ijaai.v21i4.10296
Keywords
Dupilumab Eczema Occupational dermatitis

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Gan H, Gao Y- dong. Occupational Chronic Hand Dermatitis in Hospital Environment Successfully Treated with Dupilumab: A Case Report. Iran J Allergy Asthma Immunol. 2022;21(4):484-487.