Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 21 4 2022 08 12 484 487 Hui Gan Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China AND Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Ya-dong Gao Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China 2021 10 21 2022 03 12 Duplilumab is approved to treat mild to moderate atopic dermatitis.  It is unclear, however, whether Dupilumab is effective for occupational hand eczema. In this article, we describe a 29-year-old nurse who developed severe hand eczema after working in a hospital for 6 years and received inadequate relief from routine treatment. Duplilumab was administered to the patient with great results. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3385 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/3385/1860