Intravenous Immunoglobulin in the Treatment of Lamotrigine- Induced Toxic Epidermal Necrolysis

Abstract

Toxic epidermal necrolysis is a potentially life-threatening disease, which needs necessary treatment.
We present a 12 years old female who was a known case of idiopathic generalized tonic-clonic convulsion and presented with fever, diarrhea and generalized erythematous eruption after 2 weeks of being under treatment with maintenance doses of Lamotrigine (LTG) and Valproate (VPA). The eruption led to more than 90% epidermal detachment of the total body surface area. However, she made a full recovery with few negligible sequelae regarding the severity of her disease and the symptomatic therapy and Intravenous Immunoglobulin (IVIG) administration which started soon after the bullae appeared.
While IVIG might be beneficial in the treatment of TEN, controlled studies are needed to evaluate the efficiency of IVIG compared to other modalities.