Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 7 4 2008 12 15 239 241 Serati Shirazi Zahra Department of Pediatrics, Nemazee Hospital, School of Medicine, Shiraz University of Medical Science Inaloo Soror Department of Pediatric Neurology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 2015 10 01 Toxic epidermal necrolysis is a potentially life-threatening disease, which needs necessary treatment. We present a 12 years old female who was a known case of idiopathic generalized tonic-clonic convulsion and presented with fever, diarrhea and generalized erythematous eruption after 2 weeks of being under treatment with maintenance doses of Lamotrigine (LTG) and Valproate (VPA). The eruption led to more than 90% epidermal detachment of the total body surface area. However, she made a full recovery with few negligible sequelae regarding the severity of her disease and the symptomatic therapy and Intravenous Immunoglobulin (IVIG) administration which started soon after the bullae appeared. While IVIG might be beneficial in the treatment of TEN, controlled studies are needed to evaluate the efficiency of IVIG compared to other modalities. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/226 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/226/226