Iranian Journal of Allergy, Asthma and Immunology 2013. 12(3):203-210.

Genetic Polymorphisms in Matrix Metalloproteinases -1 and -7 and Susceptibility to Gastric Cancer: an Association Study and Meta-Analysis
Wen-liang Fang, Wei-Bo Liang, Lin-Bo Gao, Bin Zhou, Feng-Li Xiao, Lin Zhang


Matrix Metalloproteinases (MMPs) play an important role in gastric cancer (GC). Accumulated evidence suggests that functional MMP-1 and MMP-7 gene polymorphisms are associated with several tumors. The aim of this study was to investigate two single nucleotide polymorphisms, MMP-1 -1607 1G/2G and MMP-7 -181 A/G, and their potential relationship with GC.

We examined 246 GC patients and 252 age-and sex-matched controls from Sichuan province in China. Genotypes were determined using a polymerase chain reaction-restriction fragment length polymorphism strategy and DNA sequencing. We also performed a meta-analysis of relevant studies, involving 1084 cases and 1721 controls, to place our findings in a broader context.

No significant relationship was observed between the MMP-1 -1607 1G/2G alleles and genotypes and the risk of GC. There were significant differences in the genotypes and allele distributions of the -181 A/G polymorphism of the MMP-7 gene between cases and controls. The -181 A allele carriers had a significantly increased risk of GC compared with -181 G allele carriers (OR=3.051, 95% CI, 1.475-6.310, P=0.002), and the AA genotype of -181 A/G was associated with an increased risk of GC compared with the AG genotype (OR=3.189, 95% CI, 1.523-6.676, P=0.001).

A meta-analysis of six studies also showed a significant risk of GC associated with MMP-7 polymorphism.


Gastric cancer; Matrix metalloproteinases; Meta-analysis; Polymorphism, Single Nucleotide

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Iranian Journal of Allergy, Asthma and Immunology, Bimonthly
ISSN: 1735-1502
(Print), ISSN: 1735-5249 (Electronic), Published by:
Tehran University of Medical Sciences

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