Original Article
  

Short Time Efficiency of Rhinophototherapy in Management of Patients with Allergic Rhinitis Resistant to Medical Therapy

Abstract

Allergic rhinitis is one of the most common health problems with a major effect on the quality of life. We intended to treat Allergic Rhinitis (AR) in patients who are either unresponsive to antihistamines or their job requires optimal alertness that may be disturbed by antihistamine’s side effects and those who do not comply with the regular use. We tried short term phototherapy and evaluated its effect on AR. As phototherapy is effective in the treatment of atopic dermatitis (AD) and the same allergens can produce both AD and AR, phototherapy is proposed as a new tool in the AR treatment. In AD, phototherapy causes induction of apoptosis in infiltrating T cells and other immunomodulatory effects. We performed a randomized single-blind study to investigate the effect of low-dose phototherapy in AR patients. Among AR patients who did not respond to local and systemic therapy, we chose 62 allergic patients all above 25 years of age with moderate to severe AR whose disease was verified by allergy skin test or specific IgE to allergens; then, they were randomly divided into 31 patients as treatment group and 31 patients as control group. In treatment groups, we used a mixture of UVA, UVB and visible light. In the control group, we used visible light alone as placebo. Then we evaluated the level of response to treatment in two groups and compared them according to Total Nasal Symptom scores (TNSS) and Global Severity Scores (GSS) and Rhinoconjunctivitis Quality of Life Questionnaires (RQLQ) symptom scores. We found out that phototherapy in the treatment group in comparison with placebo was effective in treatment of AR (p-value <0.001). However, we recommend that for substantiation of the claim, further investigations are still required

Koreck AI, Csoma z, Bodai L, Ignacz F, Kenderssy AS, Kadocsa E, et al. Rhinophototherapy: A new therapeutic tool for the management of allergic rhinitis. J Allergy Clin Immunol 2005; 115(3):541-7.
2. Corren J, Baroody F M, Pawankar R. Allergic and Non allergic Rhinitis. In: Adkinson Jr N F, Bochner B S, Burks W ,Busse W W, Holgate S T, Lemanske Jr R F, O Hehir R E, (editors). Middleton 's Allergy Principles & Practice 8th ed. Elsevier Saunders. 2014; P:664-85
3. Bousquet J, Schünemann HJ, Samolinski B, Demoly P, Baena-Cagnani CE, Bachert C, et al. Allergic Rhinitis and its Impact of Asthma (A.R.I.A.): Achievement in 10 years and future needs. J Allergy Clin Immunol 2012; 130(5):1049-62.
4. Shariat M, Pourpak Z, Khalesi M, Kazemnejad A, Sharifi L, Souzanchi G, et al. Quality of life in the Iranian adults with allergic rhinitis. Iran J Allergy Asthma Immunol 2012; 11(4):324-8
5. Juniper EF, Guyatt GH, Griffith LE, Ferrie PJ. Interpretation of rhinoconjunctivitis quality of life questionnaire data. J Allergy Clin Immunol 1996; 98(4):843-5.
6. Albu S, Baschir S. Intransal phototherapy versus azelastine in the treatment of seasonal allergic rhinitis. Auris Nasus Larynx 2013; (40):447-51.
7. Cadalli Tatar E, Korkmaz H, Surengolu UA. Effect of Rhinophototherapy on Quality of life in persistant Allergic Rhinitis. Clin Exp Otorhinolaryngol 2013; 6(2):73-7.
8. Brehmer D. Endo nasal phototherapy with Rhinolight for the treatment of allergic rhinitis. Expert Rev Med Devices 2010; 7(1):21-6.
9. Demirbash D, Aksoy E, Polat S, Serin G, Unal OF, Tanyeri H. Endonasal phototherapy in the treatment of allergic rhinitis. Kulak Burun Bogaz Ihtis Derg 2011; 21(4):198-203.
10. Leong SC. Rhinophototherapy: gimmick or an emerging treatment option for allergic rhinitis. Rhinology 2011; 49(5):499-506.
11. Garaczi E, Boros-Gyevi M, Bella Z. Intranasal phototherapy is more effective than, Photochem Photobiol 2011; 87(2):474-7.
12. Lee H M, Park M S, Park H. A comparative pilot study of symptom improvement before-and-after phototherapy in Korean patients with perennial allergic rhinitis. Photochem Photobiol 2011; 90(2):751-7.
13. Cingi C, Yaz A, Cakli H. The effect of phototherapy on quality of life in allergic rhinitis cases. Eur Arch Otorhinolaryngol 2009; 266(12):1903-8.
14. Boguniewicz M, Leung D Y M. Atopic dermatitis. In Adkinson Jr N F, Bochner B S, Burks W, Busse W W, Holgate S T, Lemanske Jr R F, O Hehir R E, (editors). Middleton's Allergy Principles & Practice 8th ed. Elsevier Saunders 2014; 540-64.
15. Koreck A, Szechenyi A, Morocz M. Effects of intranasal phototherapy on nasal mucosa in patients with allergic rhinitis. J Photochem Photobiol B 2007; 89(2-3):163-9.
16. Agrawal A, Shindell E, Jordan F. UV Radiation Increases carcinogenic risk for oral tissues compared to skin. Photochem Photobiol 2013; 89(5):1193-8.
17. Mithell D, Panker L, Sanchez G. Molecular response of nasal mucosa to therapeutic exposure to brad-band ultraviolet radiation. Journal of cellular and molecular medicine, Available at: http://www.blackwell-synergy.com/loi/jcmm/10.1111/j.1582-4934.2008.0042.
/>18. Esmaeilzadeh H, Nabavi M, Aryan Z, Arshi S, Bemanian MH, Fallahpour M, et al. Aspirin desensitization for patients with aspirin-exacerbated respiratory disease: A randomized double-blind placebo-controlled trial. Clin Immunol 2015; 160(2):349-57.

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IssueVol 15, No 4 (2016) QRcode
SectionOriginal Article(s)
Keywords
Allergic rhinitis Phototherapy Quality of life Treatment
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How to Cite
1.
Alyasin S, Nabavizadeh SH, Houshmand H, Esmaeilzadeh H, Jelodar S, Amin R. Short Time Efficiency of Rhinophototherapy in Management of Patients with Allergic Rhinitis Resistant to Medical Therapy. Iran J Allergy Asthma Immunol. 2016;15(4):317-327.