Case Report

A Case of Anaphylaxis to Patent Blue in a Patient with Sentinel Lymph Node Excision


In medicine, patent blue violet (PBV) is utilized for staining lymphatic vessels in sentinel lymph node (SLN) surgery. Moreover, PBV (also called E131 ) is used as food additive. We report on a 51-year-old non-atopic female with early breast cancer, who was scheduled for SLN excision and experienced an intra-operative anaphylactic reaction. In diagnostics the skin prick test (SPT) was positive to PBV. Hypersensitivity reactions to PBV can arise after the first exposure in surgery as sensitization may arise from either PBV (E131) in foods (i.e. in sweets or blue curacao) or from other structurally closely related triarylmethane dyes in objects of everyday life like textiles, detergents, paints, cold remedies and cosmetics. This article supports the necessity of an increased awareness of the possibility of anaphylactic reactions to PBV during SLN surgery, even if the patient never had contact to PBV before.

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IssueVol 15, No 6 (2016) QRcode
SectionCase Report(s)
Allergy Anaphylaxis Blue dye Breast cancer Patent blue violet Sentinel lymph node excision E131

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Aurich S, Seitz A-T, Tomm J, Simon J-C, Treudler R. A Case of Anaphylaxis to Patent Blue in a Patient with Sentinel Lymph Node Excision. Iran J Allergy Asthma Immunol. 2017;15(6):547-550.