Gastrointestinal Manifestations of Patients with Chronic Granulomatous Disease


Chronic Granulomatous Disease (CGD) represents a group of inherited disorders of phagocytic system, manifesting recurrent infections at different sites. The present study was accomplished in order to determine the gastrointestinal manifestations of CGD patients. Fifty-seven patients (38 males and 19 females) with CGD, who had been referred to three immunodeficiency referral centers in Iran, were studied during a 24-year period (1980-2004). The median age at the time of study was 14.5 years old (1-56 years). The median onset age of symptoms was 5 months (1 month – 13.75 years), and that of diagnostic age was 5 years (2 months- 54.1 years), with a diagnostic delay of 33 months, on average. Seven patients were presented with acute diarrhea, 3 with oral candidiasis, and 2 with liver abscesses as the first chief complaints. Twenty-four cases (42.1%) had been complicated by gastrointestinal manifestations during their course of the disease. Of those, 12 cases (21.1%) had diarrhea, 7 (12.3%) oral candidiasis, 5 (8.8%) hepatitis, 4 (7.0%) hepatic abscess, and 2 cases (3.5%) gastric outlet obstruction. Also, failure to thrive was detected in 6 patients (10.5%). Four patients died (7%). CGD should be excluded in any patient with gastrointestinal manifestations especially chronic diarrhea, hepatic abscess, and gastric outlet obstruction.
IssueVol 3, No 2 (2004) QRcode
gastrointestinal disorders

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Masoud Movahedi, Asghar Aghamohammadi, Nima Rezaei, Abolhasan Farhoudi, Zahra Pourpak, Mostafa Moin, Mohammad Gharagozlou, Davoud Mansouri, Saba Arshi, Lida Atarod, Bahram Mirsaeid Ghazi, Nikrad Shahnavaz. Gastrointestinal Manifestations of Patients with Chronic Granulomatous Disease. Iran J Allergy Asthma Immunol. 1;3(2):83-88.