Association between TNFAIP3 Gene Polymorphisms and Risk of Allergic Rhinitis in a Chinese Han Population
Abstract
Tumor necrosis factor alpha-inducible protein 3 (TNFAIP3) gene polymorphisms have been reported to be associated with the susceptibility to several immune-related diseases. Here we investigated the effect of TNFAIP3 gene polymorphisms on the risk of allergic rhinitis (AR) in a Chinese Han population. The case-control study included 540 AR patients and 524 healthy controls. Genotyping for TNFAIP3 polymorphisms (rs5029928, rs9494885, rs10499194, rs610604, and rs7753873) were performed using restriction fragment length polymorphism analysis and DNA sequencing. Allele and genotype frequencies were compared between patients and controls. The rs9494885 TC genotype (corrected p (p=0.0032); odds ratio (OR)=2.06, 95% confidence intervals (CI): 1.40-3.04) and C allele (p=0.0056; OR=1.94, 95% CI: 1.35-2.76) were more frequent in AR patients compared with controls. The frequencies of the rs9494885 TT genotype (p=0.0029; OR=0.49, 95% CI: 0.33-0.72) and T allele (p= 0.0056; OR=0.52, 95% CI: 0.36-0.74) were lower in AR patients than that in controls. A higher frequency of the rs7753873 AC genotype (p=0.0023; OR=1.96, 95 %CI: 1.38-2.77) and C allele (p=0.0012; OR=1.74, 95% CI: 1.26-2.40) and a lower frequency of the rs7753873 AA genotype (p=0.0040; OR=0.53, 95% CI: 0.38-0.75) and A allele (p=0.0012; OR=0.58, 95% CI: 0.42-0.80) were observed in AR patients. TNFAIP3 gene polymorphisms (rs9494885 and rs7753873) are associated with the susceptibility to AR in the Chinese Han population.
1. Turner RR, Testa MA, Hayes JF, Su M. Validation of the allergic rhinitis treatment satisfaction and preference scale. Allergy Asthma Proc 2013; 34(6):551-7.
2. Shen J, Ke X, Hong S, Zeng Q, Liang C, Li T, et al.Epidemiological features of allergic rhinitis in four major cities in Western China. J Huazhong Univ Sci Technolog Med Sci 2011; 31(4):433-40.
3. Petalas K, Durham SR. Allergen immunotherapy for allergic rhinitis. Rhinology 2013; 51(2):99-110.
4. Hu D, Hu G, Zhu J, Shen Y, Kang H, Hong S. Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population. PLoS One 2013;6(5):e63858.
5. Wei X, Zhang Y, Fu Z, Zhang L. The association between polymorphisms in the MRPL4 and TNF-α genes and susceptibility to allergic rhinitis. PLoS One 2013;8(3):e57981.
6. Lee EG, Boone DL, Chai S, Libby SL, Chien M, Lodolce JP, et al. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 2000;289(5488):2350-4.
7. Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M, et al. A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat Genet 2011; 43(9):908-12.
8. Catrysse L, Vereecke L, Beyaert R, van Loo G. A20 in inflammation and autoimmunity. Trends Immunol 2014;35(1):22-31.
9. Wang SZ, Ma FM, Zhao JD. Expressions of nuclear factor- kappa B p50 and p65 and their significance in the up- regulation of intercellular cell adhesion molecule-1 mRNA in the nasal mucosa of allergic rhinitis patients. Eur Arch Otorhinolaryngol 2013; 270(4):1329-34.
10. Zhang X, Li W, Zhang X, Zhao L, Zhang X, Jiang L, et al. Single nucleotide polymorphisms in TNFAIP3 were associated with the risks of rheumatoid arthritis in northern Chinese Han population. BMC Med Genet 2014;15:56.
11. Dieude P, Guedj M, Wipff J, Ruiz B, Riemekasten G, Matucci Cerinic M, et al. Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population. Ann Rheum Dis 2010;69(11):1958-64.
12. Adrianto I, Wen F, Templeton A, Wiley G, King JB, Lessard CJ, et al. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet 2011; 43(3):253-8.
13. Musone SL, Taylor KE, Nititham J, Chu C, Poon A, Liao W, et al. Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases. Genes Immun 2011; 12(3):176-82.
14. Fung EY, Smyth DJ, Howson JM, Cooper JD, Walker NM, Stevens H, et al. Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus. Genes Immun 2009; 10(2):188-91.
15. Bousquet JI, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008; (Suppl 86):8-160.
16. Liu Y, Dan G, Wu L, Chen G, Wu A, Zeng P, et al.Functional Effect of Polymorphisms in the Promoter of TNFAIP3 (A20) in Acute Pancreatitis in the Han Chinese Population. PLoS One 2014; 9(7):e103104.
17. Zhou XJ, Lu XL, Nath SK, Lv JC, Zhu SN, Yang HZ, et al. International Consortium on the Genetics of Systemic Lupus Erythematosus. Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus. Arthritis Rheum 2012; 64(1):222-31.
18. Li H, Liu Q, Hou S, Du L, Zhou Q, Zhou Y, et al.TNFAIP3 gene polymorphisms confer risk for Behcet's disease in a Chinese Han population. Hum Genet 2013;132(3):293-300.
19. Li H, Hou S, Du L, Zhou Q, Kijlstra A, Liu Q.Polymorphisms of TNFAIP3 gene in a Chinese Han population with fuchs heterochromic iridocyclitis. Ophthalmic Genet 2014; 35(2):63-7.
20. Li H, Liu Q, Hou S, Du L, Zhou Q, Zhou Y, et al.TNFAIP3 gene polymorphisms in a Chinese Han population with Vogt-Koyanagi-Harada syndrome. PLoS One.2013; 8(3):e59515.
21. Tokunaga F. Linear ubiquitination-mediated NF-κB regulation and its related disorders. J Biochem 2013;154(4):313-23.
22. Pujari R, Hunte R, Khan WN, Shembade N. A20- mediated negative regulation of canonical NF-κB signaling pathway. Immunol Res 2013; 57(1-3):166-71.
| Files | ||
| Issue | Vol 15, No 1 (2016) | |
| Section | Original Article(s) | |
| Keywords | ||
| Allergic rhinitis Gene polymorphisms Risk Single nucleotide polymorphisms TNFAIP3 | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
