Associated Markers for Adult-onset Allergic Asthma
-
Martín Bedolla-Barajas
,
Jaime Morales-Romero
,
Tonatiuh Ramses-Bedolla-Pulido
,
Lourdes Fabiola-García-Padilla
,
Dante Hernández-Colín
Abstract
The clinical behavior of asthma varies with age at onset. This study was undertaken to identify associated markers of adult-onset allergic asthma (age ≥20 years).This cross-sectional study compared two groups: 58 patients with asthma onset at <20 years and 66 with onset at ≥20 years. They were compared depending on results of clinical history, and body mass index (BMI), aeroallergen sensitization, total serum IgE, eosinophil count, asthma control test, and asthma severity level.Ages at first asthma episode were 10.0 ± 6.6 and 33.4 ± 10.5 (p <0.001) in the <20 and ≥20 group, respectively. BMI was higher in adult asthmatic subjects (29.8 versus 27.1, P=0.017), but BMI ≥30 kg/m2 was not associated with asthma onset in ≥20 years (odds ratio [OR] = 1.56, 95% confidence interval [CI] 0.759 to 3.211; p= 0.227). After multivariate analysis, allergic rhinitis and IgE ≥150 IU/mL were negatively correlated with asthma onset in ≥20 years old (OR adjusted [ORa] = 0.255, 95% CI 0.078 to 0.837, P= 0.024, and ORa =0.385, 95% CI 0.175 to 0.849, p= 0.018, respectively).Adult-onset allergic asthma was not different from early-onset asthma.
1. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention Update 2012 [Internet]. [Revised 2012; Cited: August 15, 2012]. Available from: http://www.ginasthma.org/local/uploads/files/GINA_Rep ort_March13_1.pdf.
2. Bedolla-Barajas M, Hernández-Colín DD, Sainz- Hernández J, Morales Romero J. Allergen sensitization in Mexican adults with asthma: Experience at a teaching hospital. Rev Alerg Mex 2011; 58 (3):133-41.
3. Fernández RP, Díez J de M, Álvarez-Perea A, Tapia PM, García RJ, Gómez-Piñán VS. Risk factors for asthma onset between the ages of 12 and 40. Results of the FENASMA study. Arch Bronconeumol 2011; 47(9):433-40.
4. Romanet-Manent S, Charpin D, Magnan A, Lanteaume A, Vervloet D; EGEA Cooperative Group. Allergic vs nonallergic asthma: what makes the difference? Allergy 2002; 57(7):607-13.
5. Miranda C, Busacker A, Balzar S, Trudeau J, Wenzel SE.Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. J Allergy Clin Immunol 2004; 113(1):101-8.
6. Baena-Cagnani CE, Solé D, González Díaz SN, Zernotti ME, Sisul JC, Sánchez Borges M, et al. Actualización de rinitis alérgica y su impacto en el asma (ARIA 2008). La perspectiva latinoamericana. Rev Alergia Mex 2009;56(2):56-63.
7. Schneider L, Tilles S, Lio P, Boguniewicz M, Beck L, LeBovidge J, et al. Atopic dermatitis: a practice parameter update 2012. J Allergy Clin Immunol 2013;131(2):295-9.
8. Johansson SG, Hourihane JO, Bousquet J, Bruijnzeel- Koomen C, Dreborg S, Haahtela T, et al. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 2001;56(9):813-24
9. van Kampen V, de Blay F, Folletti I, Kobierski P, Moscato G, Olivieri M, et al. EAACI position paper: skin prick testing in the diagnosis of occupational type I allergies. Allergy 2013; 68(5):580-4.
10. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J 2005; 26(2):319-38.
11. Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol 2004; 113(1):59–65.
12. Rackemann FM. A working classification of asthma. Am J Med 1947; 3(5):601-6.
13. Torén K, Ekerljung L, Kim JL, Hillström J, Wennergren G, Rönmark E, et al. Adult-onset asthma in west Sweden--incidence, sex differences and impact of occupational exposures. Respir Med 2011; 105(11):1622-8.
14. Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H,Li X, et al. National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010; 181(4):315-23.
15. MeSH Browser [database on the Internet]. Bethesda (MD): National Library of Medicine (US); 1966 [cited Aug 15, 2012]. Adult. Unique ID: D000328; [about 1 p]. Available from: http://www.nlm.nih.gov/mesh/MBrowser.html
16. Yamauchi K, Tamura G, Akasaka T, Chiba T, Honda K, Kishi M, et al. Analysis of the comorbidity of bronchial asthma and allergic rhinitis by questionnaire in 10,009 patients. Allergol Int 2009; 58(1):55-61.
17. Magnan A, Meunier JP, Saugnac C, Gasteau J, Neukirch F. Frequency and impact of allergic rhinitis in asthma patients in everyday general medical practice: a French observational cross-sectional study. Allergy 2008;63(3):292-8.
18. Linneberg A, Henrik Nielsen N, Frølund L, Madsen F, Dirksen A, Jørgensen T. Copenhagen Allergy Study. The link between allergic rhinitis and allergic asthma: a prospective population-based study. The Copenhagen Allergy Study. Allergy 2002; 57(11):1048-52.
19. Greisner WA 3rd, Settipane RJ, Settipane GA. Co- existence of asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Asthma Proc 1998; 19(4):185-8.
20. Suphioglu C, Singh MB, Taylor P, Bellomo R, Holmes P, Puy R, et al. Mechanism of grass-pollen-induced asthma. Lancet 1992; 339(8793):569-72.
21. Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol 2007; 120(3):638-46.
22. Woods RK, Abramson M, Bailey M, Walters EH.International prevalences of reported food allergies and intolerances. Comparisons arising from the European Community Respiratory Health Survey (ECRHS) 1991-1994. Eur J Clin Nutr 2001; 55(4):298-304.
23. Gaig P, Ferrer M, Muñoz-Lejarazu D, Lleonart R, García- Abujeta JL, Caballero T, et al. Allergy prevalence in adult in Spanish population. Alergol Inmunol Clin 2004;19:68-74.
24. Falcão H, Lunet N, Lopes C, Barros H. Food hypersensitivity in Portuguese adults. Eur J Clin Nutr 2004; 58(12):1621–5.
25. Borish L, Chipps B, Deniz Y, Gujrathi S, Zheng B, Dolan CM. TENOR Study Group. Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol 2005; 95(3):247-53.
26. Mediaty A, Neuber K. Total and specific serum IgE decreases with age in patients with allergic rhinitis, asthma and insect allergy but not in patients with atopic dermatitis. Immun Ageing 2005; 2(1):9.
27. Barquera S, Campos-Nonato I, Hernández-Barrera L,Pedroza A, Rivera-Dommarco JA. Prevalence of obesity in Mexican adults 2000-2012. Salud Publica Mex2013;55 (suppl 2):S151-S160.
28. Vargas MH, Díaz-Mejía GS, Furuya ME, Salas J, Lugo A. Trends of asthma in Mexico: an 11-year analysis in a nationwide institution. Chest 2004; 125(6):1993-7.
29. Bedolla-Barajas M, Morales-Romero J, Robles-Figueroa M, Fregoso-Fregoso M. Asthma in late adolescents of Western Mexico: prevalence and associated factors. Arch Bronconeumol 2013; 49(2):47-53.
| Files | ||
| Issue | Vol 14, No 5 (2015) | |
| Section | Brief Communication | |
| Keywords | ||
| Adult Asthma Biological markers Immunoglobulin E | ||
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