Hallucination Development with Montelukast in a Child with Asthma: Case Presentation
Abstract
Leukotriene receptor antagonists(montelukast) have been used for many years in the treatment of asthma both acute and chronic stages. They are accepted commonly as safe but mostly possible side effects are ignored. However, montelukast also could lead to important adverse reactions like hallucinations. In literature only 2 reports have been found about hallucinations with it. One is a study which reports 3 patients from 48 children and the other is a 29 year-old case report. In our case, psychiatric adverse reactions of montelukast,especially hallucinations are reported similarly. We are presenting a child who had visual hallucinations after starting to use montekulast and after stopping the medicine these complaints disappeared in 48 hours. Although it is a safe drug, it should not be forgotten that it has psychiatric side effects which may be missed easily especially in children.
1. Price D, Musgrave SD, Shepstone L, Hillyer EV, Sims EJ, Gilbert RF, et al. Leukotriene Antagonists as First Line or Add-on Asthma-Controller Therapy. N Engl J Med 2011; 364(18):1695-707.
2. Igde M, Anlar FY. The efficacy of montelukast monotherapy in moderate persistent asthmatic children. Iran J Allergy Asthma Immunol 2009; 8(3):169-70.
3. Barnes PJ, Drazen JM, Rennard SI, Thompson NC editors. Pathophysiology of asthma. In Asthma and COPD: Basic Mechanisms and Clinical Management. 2nd edition, 2009; 33:401-19.
4. Mandeep W, Rakesh L, Kabra SK. Montelukast in Pediatric Asthma Management. Indian J Pediatr 2006;73(4):275-82.
5. Visitsunthorn N, Chirdjirapong V, Santadilog S, Pajarn P, Jirapongsananuruk O, Komoltri C, et al. The effect of montelukast on bronchial hyperreactivity and lung function in asthmatic children aged 6-13 years. Asian Pac J Allergy Immunol 2011; 29(2):127-33.
6. Bond WS. Recognition and treatment of attention deficit disorder. Clin Pharm 1987; 6(8):617-24.
7. Wallerstedt SM, Brunlöf G, Sundström A, Eriksson AL.Montelukast and psychiatric disorders in children. Pharmacoepidemiol Drug Saf 2009; 18(9):858- 64.
8. Philip G, Hustad CM, Malice MP, Noonan G, Ezekowitz A, Reiss TF, et al. Analysis of behavior-related adverse experiences in clinical trials of montelukast. J Allergy Clin Immunol 2009; 124(4):699-706.
9. Anandan N, Ibitoye F. Montelukast and worsening of hallucinationsin paranoid schizophrenia. The Psychiatrist.2008; 32:276.
10. Boyce JA. Mast cells: beyond IgE. J Allergy Clin Immunol 2003; 111(1):24–32.
11. Postolache TT, Komarow H, Tonelli LH. Allergy: A risk factor for suicide? Curr Treat Options Neurol 2008;10(5):363-76.
Files | ||
Issue | Vol 12, No 4 (2013) | |
Section | Articles | |
Keywords | ||
Adverse reactions Asthma Hallucination Children Montelukast |
Rights and permissions | |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |