Rosiglitazone Inhibits HMC-1 Cell Migration and Adhesion through a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Mechanism
-
Guqin Zhang
,
Jiong Yang
,
Ping Li
,
Jie Cao
,
Hanxiang Nie
Abstract
Mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the large nuclear hormone receptor transcription factor superfamily, and has been recently implicated in the anti-inflammatory response.
To investigate a possible role for PPARγ in human mast cells, we studied the effects of a
PPARγ ligand, rosiglitazone (RG), on stem cell factor (SCF)-induced migration and fibronectin-induced adhesion in human mast cell-1(HMC-1) cells.
It was found that HMC-1 cells expressed PPARγ mRNA. RG inhibited SCF-induced HMC-1 cell migration and fibronectin-induced HMC-1 cell adhesion, the selective PPARγ antagonist GW9662 prevented the inhibitory effect of RG on HMC-1 cells.
In conclusion, RG inhibits the migration and adhesion of HMC-1 cells by a PPARγ-dependent mechanism.
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| Issue | Vol 13, No 1 (2014) | |
| Section | Articles | |
| Keywords | ||
| Adhesion Mast cells Migration PPARγ Rosiglitazone | ||
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