Association between CTLA4 +49A/G Polymorphism and Childhood Asthma Susceptibility: A Meta-analysis
-
Yabin Chen
,
Hua Xu
,
Xunchao Ji
,
Juan Xiao
Abstract
To investigate the association between single nucleotide polymorphism (SNP) of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) +49A/G locus and the risk of asthma in children by meta-analysis.
Six databases were searched for records on the association between CTLA-4 +49A/G locus polymorphism and pediatric asthma. The retrieval time was from the establishment of each database to July 2024. Stata 15.0 software was applied, with the pooled OR and 95% CI calculated. Five genetic models (G/A, GA+AA/AA, G/GA+AA, GG/AA, and GA/AA) were analyzed.
Nine studies were included, covering 2133 Cases and 1572 controls. The combined results exhibited that the differences were all statistically significant under the allelic (OR, 0.53; 95% CI, 0.35-0.79), dominant (OR, 0.41; 95% CI, 0.24-0.71), recessive(OR, 0.60; 95% CI, 0.41-0.89), homozygous (OR, 0.38; 95% CI, 0.22-0.68) and heterozygous (OR, 0.52; 95% CI, 0.33-0.80) models.
The meta-analysis indicates that CTLA-4 +49A/G SNP is related to susceptibility to pediatric asthma, and allele G and genotype GG+GA, GG, and GA correlated with a decreased risk of asthma.
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16. Sohn MH, Kim S, Song T, Kim K, Kim E, Park H, et al. Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children. Pediatr Pulm. 2007;42(6):542-7.
17. Chan IHS, Tang NLS, Leung TF, Huang W, Lam YYO, Li CY, et al. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. Allergy. 2008;63(8):1031-9.
18. Oh K, Kang M, Choi W, Kwon J, Kim B, Yu J, et al. Association Between Serum IgE Levels and the CTLA4 +49A/G and FCER1B -654C/T Polymorphisms in Korean Children With Asthma. Allergy Asthma Immunol Res. 2010;2(2):127-33.
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21. Wang D, De-Fa LI, Yuan Y et al. Study on the association between CTLA4 genes SNPS and pediactric asthma susceptibility in Shenzhen. Chinese J Health Laboratory Technology. 2014.
22. Song SH, Wang XQ, Shen Y, Hong SL, Ke X. Association between PTPN22/CTLA-4 Gene Polymorphism and Allergic Rhinitis with Asthma in Children. Iran J Allergy Asthma Immunol 2016;15(5):413-9.
23. Xu QR, Song L, Zhang Y. Association between CTLA-4 gene polymorphism with childhood bronchial asthmatic susceptibility and levels of IFN-，IL-4 and IgE in peripheral blood. Chinese Journal of Child Health. 2020;28(1):32-36.
24. Centers FDCA. Vital signs: asthma prevalence, disease characteristics, and self-management education: United States, 2001--2009. MMWR. Morbidity and Mortality Weekly Report. 2011;60(17):547-52.
2. Foster PS, Webb DC, Yang M, Herbert C, Kumar RK. Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma. Clin Exp Allergy. 2003;33(5):688-95.
3. Browne LR, Gorelick MH. Asthma and pneumonia. Pediatr Clin N Am. 2010;57(6):1347-56.
4. Johnson CC, Chandran A, Havstad S, Li X, McEvoy CT, Ownby DR, et al. US Childhood Asthma Incidence Rate Patterns From the ECHO Consortium to Identify High-risk Groups for Primary Prevention. JAMA Pediatr. 2021;175(9):919-27.
5. Tanno LK, Haahtela T, Calderon MA, Cruz A, Demoly P, Joint AA. Implementation gaps for asthma prevention and control. Respir Med. 2017;130:13-9.
6. Boulet L, Reddel HK, Bateman E, Pedersen S, FitzGerald JM, O’Byrne PM. The Global Initiative for Asthma (GINA): 25 years later. Eur Respir J. 2019;54(2):1900598.
7. Hahn AW, Gill DM, Pal SK, Agarwal N. The future of immune checkpoint cancer therapy after PD-1 and CTLA-4. Immunotherapy-Uk. 2017;9(8):681-92.
8. Azuma M, Ito D, Yagita H, Okumura K, Phillips JH, Lanier LL, et al. B70 antigen is a second ligand for CTLA-4 and CD28. Nature. 1993;366:6450):76-9.
9. Ren D, He L, Pang X. Association of CLTA-4 Gene Polymorphisms with Diabetes Mellitus: A Study Based on the Han Population of Northern China. Diabet Metab Synd Ob. 2022;15:2705-12.
10. Louthrenoo W, Kasitanon N, Wongthanee A, Kuwata S, Takeuchi F. CTLA-4 polymorphisms in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis. Int J Rheum Dis. 2021;24(11):1378-85.
11. Nie W, Chen J, Xiu Q. Cytotoxic T-lymphocyte associated antigen 4 polymorphisms and asthma risk: a meta-analysis. PLoS One. 2012;7(7):e42062.
12. Zheng Y, Wang H, Luo L, Liao L, You L, Wang J, et al. A meta-analysis of the association between CTLA-4 genetic polymorphism and susceptibility of asthma. Medicine. 2018;97(28):e11380.
13. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603-5.
14. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539-58.
15. Nakao F, Ihara K, Ahmed S, Sasaki Y, Kusuhara K, Takabayashi A, et al. Lack of association between CD28/CTLA-4 gene polymorphisms and atopic asthma in the Japanese population. Exp Clin Immunogenet. 2000;17(4):179-84.
16. Sohn MH, Kim S, Song T, Kim K, Kim E, Park H, et al. Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children. Pediatr Pulm. 2007;42(6):542-7.
17. Chan IHS, Tang NLS, Leung TF, Huang W, Lam YYO, Li CY, et al. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. Allergy. 2008;63(8):1031-9.
18. Oh K, Kang M, Choi W, Kwon J, Kim B, Yu J, et al. Association Between Serum IgE Levels and the CTLA4 +49A/G and FCER1B -654C/T Polymorphisms in Korean Children With Asthma. Allergy Asthma Immunol Res. 2010;2(2):127-33.
19. Undarmaa S, Mashimo Y, Hattori S, Shimojo N, Fujita K, Miyatake A, et al. Replication of genetic association studies in asthma and related phenotypes. J Hum Genet. 2010;55(6):342-9.
20. Zhang L, Miao X, Wang H. The relationship of Cytotoxic T-lymphocyte antigen-4 functional genetic polymorphism and the risk for the occurrence of children asthma. Chinese J Birth Health Heredity. 2010;86909808.
21. Wang D, De-Fa LI, Yuan Y et al. Study on the association between CTLA4 genes SNPS and pediactric asthma susceptibility in Shenzhen. Chinese J Health Laboratory Technology. 2014.
22. Song SH, Wang XQ, Shen Y, Hong SL, Ke X. Association between PTPN22/CTLA-4 Gene Polymorphism and Allergic Rhinitis with Asthma in Children. Iran J Allergy Asthma Immunol 2016;15(5):413-9.
23. Xu QR, Song L, Zhang Y. Association between CTLA-4 gene polymorphism with childhood bronchial asthmatic susceptibility and levels of IFN-，IL-4 and IgE in peripheral blood. Chinese Journal of Child Health. 2020;28(1):32-36.
24. Centers FDCA. Vital signs: asthma prevalence, disease characteristics, and self-management education: United States, 2001--2009. MMWR. Morbidity and Mortality Weekly Report. 2011;60(17):547-52.
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| Issue | Vol 25 No 5 (2026) | |
| Section | Original Article(s) | |
| Keywords | ||
| Asthma Children CTLA-4 Polymorphism | ||
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How to Cite
1.
Chen Y, Xu H, Ji X, Xiao J. Association between CTLA4 +49A/G Polymorphism and Childhood Asthma Susceptibility: A Meta-analysis. Iran J Allergy Asthma Immunol. 2026;25(5):656-662.
