Association between CTLA4 +49A/G Polymorphism and Childhood Asthma Susceptibility: A Meta-analysis
-
Yabin Chen
,
Hua Xu
,
Xunchao Ji
,
Juan Xiao
Abstract
To investigate the association between single nucleotide polymorphism (SNP) of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) +49A/G locus and the risk of asthma in children by meta-analysis.
Six databases were searched for records on the association between CTLA-4 +49A/G locus polymorphism and pediatric asthma. The retrieval time was from the establishment of each database to July 2024. Stata 15.0 software was applied, with the pooled OR and 95% CI calculated. Five genetic models (G/A, GA+AA/AA, G/GA+AA, GG/AA, and GA/AA) were analyzed.
Nine studies were included, covering 2133 Cases and 1572 controls. The combined results exhibited that the differences were all statistically significant under the allelic (OR, 0.53; 95% CI, 0.35-0.79), dominant (OR, 0.41; 95% CI, 0.24-0.71), recessive(OR, 0.60; 95% CI, 0.41-0.89), homozygous (OR, 0.38; 95% CI, 0.22-0.68) and heterozygous (OR, 0.52; 95% CI, 0.33-0.80) models.
The meta-analysis indicates that CTLA-4 +49A/G SNP is related to susceptibility to pediatric asthma, and allele G and genotype GG+GA, GG, and GA correlated with a decreased risk of asthma.
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2. Foster PS, Webb DC, Yang M, Herbert C, Kumar RK. Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma. Clin Exp Allergy. 2003;33(5):688-95.
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7. Hahn AW, Gill DM, Pal SK, Agarwal N. The future of immune checkpoint cancer therapy after PD-1 and CTLA-4. Immunotherapy-Uk. 2017;9(8):681-92.
8. Azuma M, Ito D, Yagita H, Okumura K, Phillips JH, Lanier LL, et al. B70 antigen is a second ligand for CTLA-4 and CD28. Nature. 1993;366:6450):76-9.
9. Ren D, He L, Pang X. Association of CLTA-4 Gene Polymorphisms with Diabetes Mellitus: A Study Based on the Han Population of Northern China. Diabet Metab Synd Ob. 2022;15:2705-12.
10. Louthrenoo W, Kasitanon N, Wongthanee A, Kuwata S, Takeuchi F. CTLA-4 polymorphisms in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis. Int J Rheum Dis. 2021;24(11):1378-85.
11. Nie W, Chen J, Xiu Q. Cytotoxic T-lymphocyte associated antigen 4 polymorphisms and asthma risk: a meta-analysis. Plos One. 2012;7(7):e42062.
12. Zheng Y, Wang H, Luo L, Liao L, You L, Wang J, et al. A meta-analysis of the association between CTLA-4 genetic polymorphism and susceptibility of asthma. Medicine. 2018;97(28):e11380.
13. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603-5.
14. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539-58.
15. Nakao F, Ihara K, Ahmed S, Sasaki Y, Kusuhara K, Takabayashi A, et al. Lack of association between CD28/CTLA-4 gene polymorphisms and atopic asthma in the Japanese population. Experimental and Clinical Immunogenetics. 2000;17(4):179-84.
16. Sohn MH, Kim S, Song T, Kim K, Kim E, Park H, et al. Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children. Pediatr Pulm. 2007;42(6):542-7.
17. Chan IHS, Tang NLS, Leung TF, Huang W, Lam YYO, Li CY, et al. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. Allergy. 2008;63(8):1031-9.
18. Oh K, Kang M, Choi W, Kwon J, Kim B, Yu J, et al. Association Between Serum IgE Levels and the CTLA4 +49A/G and FCER1B -654C/T Polymorphisms in Korean Children With Asthma. Allergy, Asthma & Immunology Research. 2010;2(2):127-33.
19. Undarmaa S, Mashimo Y, Hattori S, Shimojo N, Fujita K, Miyatake A, et al. Replication of genetic association studies in asthma and related phenotypes. J Hum Genet. 2010;55(6):342-9.
20. Zhang L, Miao X, Wang H. The relationship of Cytotoxic T-lymphocyte antigen-4 functional genetic polymorphism and the risk for the occurrence of children asthma. Chinese Journal of Birth Health & Heredity. 2010; 86909808.
21. Wang D, De-Fa LI, Yuan Y et al. Study on the association between CTLA4 genes SNPS and pediactric asthma susceptibility in Shenzhen. Chinese Journal of Health Laboratory Technology. 2014.
22. Song SH, Wang XQ, Shen Y, Hong SL, Ke X. Association between PTPN22/CTLA-4 Gene Polymorphism and Allergic Rhinitis with Asthma in Children. Iran J Allergy Asthm. 2016;15(5):413-9.
23. Xu QR, Song L, Zhang Y. Association between CTLA-4 gene polymorphism with childhood bronchial asthmatic susceptibility and levels of IFN-，IL-4 and IgE in peripheral blood. Chinese Journal of Child Health. 2020;28(1):32-36.
24. Centers FDCA. Vital signs: asthma prevalence, disease characteristics, and self-management education: United States, 2001--2009. MMWR. Morbidity and Mortality Weekly Report. 2011;60(17):547-52.
2. Foster PS, Webb DC, Yang M, Herbert C, Kumar RK. Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma. Clin Exp Allergy. 2003;33(5):688-95.
3. Browne LR, Gorelick MH. Asthma and pneumonia. Pediatr Clin N Am. 2010;57(6):1347-56.
4. Johnson CC, Chandran A, Havstad S, Li X, McEvoy CT, Ownby DR, et al. US Childhood Asthma Incidence Rate Patterns From the ECHO Consortium to Identify High-risk Groups for Primary Prevention. Jama Pediatr. 2021;175(9):919-27.
5. Tanno LK, Haahtela T, Calderon MA, Cruz A, Demoly P, Joint AA. Implementation gaps for asthma prevention and control. Resp Med. 2017;130:13-9.
6. Boulet L, Reddel HK, Bateman E, Pedersen S, FitzGerald JM, O’Byrne PM. The Global Initiative for Asthma (GINA): 25 years later. The European Respiratory Journal. 2019;54(2):1900598.
7. Hahn AW, Gill DM, Pal SK, Agarwal N. The future of immune checkpoint cancer therapy after PD-1 and CTLA-4. Immunotherapy-Uk. 2017;9(8):681-92.
8. Azuma M, Ito D, Yagita H, Okumura K, Phillips JH, Lanier LL, et al. B70 antigen is a second ligand for CTLA-4 and CD28. Nature. 1993;366:6450):76-9.
9. Ren D, He L, Pang X. Association of CLTA-4 Gene Polymorphisms with Diabetes Mellitus: A Study Based on the Han Population of Northern China. Diabet Metab Synd Ob. 2022;15:2705-12.
10. Louthrenoo W, Kasitanon N, Wongthanee A, Kuwata S, Takeuchi F. CTLA-4 polymorphisms in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis. Int J Rheum Dis. 2021;24(11):1378-85.
11. Nie W, Chen J, Xiu Q. Cytotoxic T-lymphocyte associated antigen 4 polymorphisms and asthma risk: a meta-analysis. Plos One. 2012;7(7):e42062.
12. Zheng Y, Wang H, Luo L, Liao L, You L, Wang J, et al. A meta-analysis of the association between CTLA-4 genetic polymorphism and susceptibility of asthma. Medicine. 2018;97(28):e11380.
13. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603-5.
14. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539-58.
15. Nakao F, Ihara K, Ahmed S, Sasaki Y, Kusuhara K, Takabayashi A, et al. Lack of association between CD28/CTLA-4 gene polymorphisms and atopic asthma in the Japanese population. Experimental and Clinical Immunogenetics. 2000;17(4):179-84.
16. Sohn MH, Kim S, Song T, Kim K, Kim E, Park H, et al. Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children. Pediatr Pulm. 2007;42(6):542-7.
17. Chan IHS, Tang NLS, Leung TF, Huang W, Lam YYO, Li CY, et al. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. Allergy. 2008;63(8):1031-9.
18. Oh K, Kang M, Choi W, Kwon J, Kim B, Yu J, et al. Association Between Serum IgE Levels and the CTLA4 +49A/G and FCER1B -654C/T Polymorphisms in Korean Children With Asthma. Allergy, Asthma & Immunology Research. 2010;2(2):127-33.
19. Undarmaa S, Mashimo Y, Hattori S, Shimojo N, Fujita K, Miyatake A, et al. Replication of genetic association studies in asthma and related phenotypes. J Hum Genet. 2010;55(6):342-9.
20. Zhang L, Miao X, Wang H. The relationship of Cytotoxic T-lymphocyte antigen-4 functional genetic polymorphism and the risk for the occurrence of children asthma. Chinese Journal of Birth Health & Heredity. 2010; 86909808.
21. Wang D, De-Fa LI, Yuan Y et al. Study on the association between CTLA4 genes SNPS and pediactric asthma susceptibility in Shenzhen. Chinese Journal of Health Laboratory Technology. 2014.
22. Song SH, Wang XQ, Shen Y, Hong SL, Ke X. Association between PTPN22/CTLA-4 Gene Polymorphism and Allergic Rhinitis with Asthma in Children. Iran J Allergy Asthm. 2016;15(5):413-9.
23. Xu QR, Song L, Zhang Y. Association between CTLA-4 gene polymorphism with childhood bronchial asthmatic susceptibility and levels of IFN-，IL-4 and IgE in peripheral blood. Chinese Journal of Child Health. 2020;28(1):32-36.
24. Centers FDCA. Vital signs: asthma prevalence, disease characteristics, and self-management education: United States, 2001--2009. MMWR. Morbidity and Mortality Weekly Report. 2011;60(17):547-52.
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How to Cite
1.
Chen Y, Xu H, Ji X, Xiao J. Association between CTLA4 +49A/G Polymorphism and Childhood Asthma Susceptibility: A Meta-analysis. Iran J Allergy Asthma Immunol. 2026;:1-7.
