Original Article
  

Allergies and Lung Cancer: Exploring the Association with Allergic Rhinitis

Abstract

Allergy and lung cancer are two distinct health concerns. While allergies are typically associated with heightened immune activity, such immune responses may also influence the tumor microenvironment. This study aimed to investigate a potential link between allergic conditions and the risk of lung cancer.
We conducted a case-control study analyzing 82 histologically confirmed lung cancer patients and 82 healthy controls from 2019 to 2022. Data were collected through structured questionnaires assessing asthma, allergic rhinitis (AR), food/drug allergies, and chronic urticaria. Statistical analyses included independent samples t-tests and chi-square tests, with significance set at a predetermined threshold.
We observed a significant inverse association between AR and lung cancer (8.54% vs 47.56% in controls; OR=0.14, 95% CI: 0.06–0.32). No significant associations were found for asthma (7.32% vs 3.66%), chronic urticaria (3.66% vs 3.66%), drug allergy (4.88% vs 1.22%), or food allergy (2.44% vs 6.10%). The association between AR and lung cancer remained robust after adjustment for demographic factors.
AR demonstrated a strong negative association with lung cancer, suggesting potential protective mechanisms distinct from other allergic conditions. These findings support the growing evidence for allergy-cancer immunomodulatory interactions and highlight the need for mechanistic studies on AR-specific pathways in oncogenesis.

Li C, Lei S, Ding L, Xu Y, Wu X, Wang H, et al. Global burden and trends of lung cancer incidence and mortality. Chin Med J (Engl). 2023; l 5;136(13):1583-90.
2. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-49.
3. Zhou J, Xu Y, Liu J, Feng L, Yu J, Chen D. Global burden of lung cancer in 2022 and projections to 2050: Incidence and mortality estimates from GLOBOCAN. Cancer Epidemiol. 2024;93:102693.
4. Mostafavi A, Saidi MS, Moghtaderi M. Three-dimensional simulation of circulating tumor cells magnetic isolation using a viscoelastic-based ferrofluid solution. Journal of Magnetism and Magnetic Materials.2025;619: 172847.
5. Ruano-Ravina A, Figueiras A, Barros-Dios JM. Lung cancer and related risk factors: an update of the literature. Public Health. 2003;117(3):149-56.
6. Asomaning K, Miller DP, Liu G, Wain JC, Lynch TJ, Su L, et al. Second hand smoke, age of exposure and lung cancer risk. Lung Cancer. 2008;61(1):13-20.
7. Dave ND, Xiang L, Rehm KE, Marshall GD Jr. Stress and allergic diseases. Immunol Allergy Clin North Am. 2011;31(1):55-68.
8. Abbas M, Moussa M, Akel H. Type I Hypersensitivity Reaction. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-
9. Jensen-Jarolim E, Achatz G, Turner MC, Karagiannis S, Legrand F, Capron M, et al. AllergoOncology: the role of IgE-mediated allergy in cancer. Allergy. 2008;63(10):1255-66.
10. Chauhan J, McCraw AJ, Nakamura M, Osborn G, Sow HS, Cox VF, et al. IgE Antibodies against Cancer: Efficacy and Safety. Antibodies (Basel). 2020;9(4):55.
11. Kantor ED, Hsu M, Du M, Signorello LB. Allergies and Asthma in Relation to Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2019;28(8):1395-403.
12. Fereidouni M, Ferns GA, Bahrami A. Current status and perspectives regarding the association between allergic disorders and cancer. IUBMB Life. 2020; 72(7):1322-1339.
13. Kay J, Thadhani E, Samson L, Engelward B. Inflammation-induced DNA damage, mutations and cancer. DNA Repair (Amst). 2019;83:102673.
14. Ye, L., Wang, F., Wu, H. et al. Evidence of the association between asthma and lung cancer risk from mendelian randomization analysis. Sci Rep. 2024;23047.
15. Koh WP, Yuan JM, Wang R, Seow A, Lee HP, Yu MC. Chronic rhinosinusitis and risk of lung cancer in the Singapore Chinese Health Study. Int J Cancer. 2008; 15;123(6):1398-402.
16. Bekaert S, Rocks N, Vanwinge C, Noel A, Cataldo D. Asthma-related inflammation promotes lung metastasis of breast cancer cells through CCL11-CCR3 pathway. Respir Res. 2021;22(1):61.
17. Jarvis D, Newson R, Lotvall J, Hastan D, Tomassen P, Keil T, et al. Asthma in adults and its association with chronic rhinosinusitis: the GA2LEN survey in Europe. Allergy. 2012;67(1):91-8.
18. El-Zein M, Parent ME, Siemiatycki J, et al. History of allergic diseases and lung cancer risk. Ann Allergy Asthma Immunol. 2014;112:230–6.
19. Khan QU, Rehman MU, Abbasi MAA, Shiekh RR, Nazir M, Raja SK, et al. Correlation between allergic rhinitis or hay fever and lung cancer: A systematic review and meta-analysis. Medicine (Baltimore). 2024; 17; 03(20):e38197.
20. Jensen-Jarolim E, Achatz G, Turner MC, et al. The role of IgE-mediated allergy in cancer. Allergy. 2008;63:1255–66.
21. Wen Y, Zhu Y, Zhang C, Yang X, Gao Y, Li M, et al. Chronic inflammation, cancer development and immunotherapy. Front Pharmacol. 2022;14;13:1040163.
22. Wang IJ, Liang WM, Wu TN, Karmaus WJJ, Hsu JC. Inhaled corticosteroids may prevent lung cancer in asthma patients. Ann Thorac Med. 2018;13(3):156-62.
23. Boffetta P, Ye W, Boman G, Nyrén. Lung cancer risk in a population-based cohort of patients hospitalized for asthma in Sweden. Eur Respir J. 2002;19(1):127-33.
24. Qu YL, Liu J, Zhang LX, Wu CM, Chu AJ, Wen BL, et al. Asthma and the risk of lung cancer: a meta-analysis. Oncotarget. 2017; 14;8(7):11614-20.
25. Walser T, Cui X, Yanagawa J, Lee JM, Heinrich E, Lee G, et al. Smoking and lung cancer: the role of inflammation. Proc Am Thorac Soc. 2008;5(8):811-5.
26. Hecht SS. Lung carcinogenesis by tobacco smoke. Int J Cancer. 2012; 131(12):2724-32.
27. Warren GW, Cummings KM. Tobacco and lung cancer: risks, trends, and outcomes in patients with cancer. Am Soc Clin Oncol Educ Book. 2013:359-64.
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SectionOriginal Article(s)
Keywords
Allergic rhinitis Asthma Cancer immunology Hypersensitivity Lung cancer
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How to Cite
1.
Moghtaderi M, Rezaianzadeh A, Nabavizadeh SH, Kanannejad Z, Khosravizadegan Z, Asnaashari K. Allergies and Lung Cancer: Exploring the Association with Allergic Rhinitis. Iran J Allergy Asthma Immunol. 2026;:1-7.