Articles
  

YKL-40 in Asthma and its Correlation with Different Clinical Parameters

Abstract

It has been suggested that elevated serum level of YKL-40 could be a marker for asthma and its severity. Along with few published studies, we investigated its correlation with asthma and its severity as well as spirometric indices.114 patients with asthma and 114 healthy controls underwent the assessment of serum level of YKL-40 (by ELISA) and spirometric indices. Pearson's coefficient determined the correlation between the variables and multivariate linear regression analysis was used for adjusting the effect of different probable confounding factors.Serum levels of YKL-40 were significantly higher in the asthmatic patients compared to those in healthy people (p<0.001). We also found a significant correlation between YKL-40 serum level and spirometric indices even after adjusting the effects of other variables.We report for the first time in an Iranian population that YKL-40 may be a good diagnostic marker of asthma in serum.

1. Moffatt MF, Cookson WO. Asthma and chitinases. N Engl J Med 2008; 358(16):1725-6.
2. Frew AJ. Asthma biomarkers and drug trials. J Allergy Clin Immunol 2002; 109(2): 210-3.
3. Ober C, Chupp GL. The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases. Curr Opin Allergy Clin Immunol 2009; 9(5):401-8.
4. Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY,Cohn L, et al. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science 2004; 304(5677):1678-82.
5. Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, et al. Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med 2008; 358(16):1682-91.
6. Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, et al. A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med.2007; 357(20):2016-27.
7. Snell N, Newbold P. The clinical utility of biomarkers in asthma and COPD. Curr Opin Pharmacol 2008; 8(3):222-35.
8. Global Strategy for Asthma Management and Prevention 2008 (update), CHAPTER 2: 22 The GINA reports are available on www.ginasthma.org
9. Schultz NA, JS Johansen. YKL-40- A Protein in the Field of Translational Medicine: A Role as a Biomarker in Cancer Patients? Cancers 2010; 2(3):1453-91.
10. Kazakova MH, Sarafian VS. YKL-40--a novel biomarker in clinical practice? Folia Med (Plovdiv) 2009; 51(1):5-14.
11. Johansen JS. Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer. Dan Med Bull 2006; 53(2):172-209.
12. Johansen JS, Lottenburger T, Nielsen HJ, Jensen JE, Svendsen MN, Kollerup G, et al. Diurnal, weekly, and long-time variation in serum concentrations of YKL-40 in healthy subjects. Cancer Epidemiol Biomarkers Prev 2008; 17(10):2603-8.
13. Johansen JS, Bojesen SE, Mylin AK, Frikke-Schmidt R, Price PA, Nordestgaard BG. Elevated plasma YKL-40 predicts increased risk of gastrointestinal cancer and decreased survival after any cancer diagnosis in the general population. J Clin Oncol 2009; 27(4):572-8.
14. Guerra S, Halonen M, Sherrill DL, Venker C, Spangenberg A, Carsin AE, et al. The relation of circulating YKL-40 to levels and decline of lung function in adult life. Respir Med 2013. pii: S0954-6111(13)00266-7.
15. Junker N, Johansen JS, Andersen CB, Kristjansen PE.Expression of YKL-40 by peritumoral acrophages in human small cell lung cancer. Lung Cancer 2005;48(2):223-31.
16. Johansen JS, Drivsholm L, Price PA, Christensen IJ.High serum YKL-40 level in patients with small cell lung cancer is related to early death. Lung Cancer 2004;46(3):333-40.
17. Johansen JS, Cintin C, Jorgensen M, et al.Serum YKL-40: a new potential marker of prognosis and location of metastases of patients with recurrent breast cancer. Eur J Cancer 1995; 31A(9):1437-42.
18. Østergaard C, Johansen JS, Benfield T, Price PA,Lundgren JD. YKL-40 is elevated in cere-brospinal fluid from patients with purulent meningitis. Clin Diagn Lab Immunol 2002; 9(3):598–604.
19. Kronborg G, Ostergaard C, Weis N, Nielsen H,Obel N, Pedersen SS, et al. Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease. Scand J Infect Dis 2002; 34(5):323-6.
20. Nordenbaek C, Johansen JS, Junker P, Borregaard N, Sørensen O, Price PA et al. YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization. J Infect Dis 1999; 180(5):1722–6.
21. Volck B, Johansen JS, Stoltenberg M, Garbarsch C, Price PA, Ostergaard M et al. Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology. Osteoarthritis Cartilage 2001; 9(3):203-14.
22. Matsumoto T, Tsurumoto T. Serum YKL-40 levels in rheumatoid arthritis: correlations between clinical and laboratory parameters. Clin Exp Rheumatol 2001;19(6):655-60.
23. Brunner JK, Scholl-Bürgi S, Hössinger D, Wondrak P, Prelog M, Zimmerhackl LB. Chitotriosidase activity in juvenile idiopathic arthritis. Rheumatol Int 2008;28(9):949-50.
24. Lommatzsch M, Julius P, Kuepper M, Garn H, Bratke K, Irmscher S et al. The course of allergen- induced leukocyte infiltration in human and experimental asthma. J Allergy Clin Immunol 2006; 118(1):91-7.
25. Tang H, Fang Z, Sun Y, Li B, Shi Z, Chen J, et al.YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin E. Eur Respir J 2010; 35(4):757-60.
26. Tarek AG, Mervat GEM, Manal AA, Bothina E. Serum YKL-40 and assessment of severity of bronchial asthma in Egyptian children. Egypt J Pediatr Allergy Immunol 2011; 9(2):93-7.
27. Duru S, Yüce G, Ulasli SS, Erdem M, Kizilgün M, Kara F, et al. The Relationship between Serum YKL-40 Levels and Severity of Asthma. Iran J Allergy Asthma Immunol 2013; 12(3):247-53.

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IssueVol 13, No 4 (2014) QRcode
SectionArticles
Keywords
Asthma Respiratory Indices YKL-40
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How to Cite
1.
Saba M, Sharif MR, Akbari H, Nikoueinejad H, Ramazani Jolfaii M. YKL-40 in Asthma and its Correlation with Different Clinical Parameters. Iran J Allergy Asthma Immunol. 1;13(4):271-277?.