Allergic Diseases and Head and Neck Cancer: A Systematic Review and Meta-analysis
,
Abstract
Allergic disorders such as asthma, atopic dermatitis, and allergic rhinitis affect a large portion of the global population. The relationship between allergies and cancer has been studied extensively, but results remain inconsistent for head and neck cancer. The aim of this meta-analysis is to evaluate whether there is a negative association between allergic disorders and head and neck cancer. A systematic search of five databases was conducted based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Cohort- and case-control studies examining allergies and head and neck cancer were included. Random-effect and fixed-effect models were used to calculate pooled relative risk, with heterogeneity assessed via the I2 and Cochrane’s Q-test. Subgroup and sensitivity analyses were performed to explore variations by study design, allergy type, and cancer site. Twenty-five studies with 3.6 million participants were included. No significant overall association was found between allergic diseases and head and neck cancer (meta-RR: 0.89; 95% confidence intervals (CI): 0.76–1.05). Subgroup analyses revealed protective effects for asthma (meta-RR: 0.81; 95% CI: 0.70–0.95) and food allergies (meta-RR: 0.73; 95% CI: 0.54–0.99). Allergic rhinitis showed negative associations with oropharyngeal cancer (meta-RR: 0.76; 95% CI: 0.69–0.84) and hypopharyngeal cancer (meta-RR: 0.65; 95% CI: 0.55–0.78), but a positive association with nasopharyngeal cancer (meta-RR: 1.67; 95% CI: 1.15–2.43). These findings suggest complex relationships between allergies and head and neck cancer, with negative and positive associations varying by allergy type and cancer site. Further research is needed to clarify these associations.
1. Shin YH, Hwang J, Kwon R, Lee SW, Kim MS, Shin JI, et al. Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019. Allergy. 2023;78(8):2232-54.
2. Hendaus MA, Jomha FA, Ehlayel M. Allergic diseases among children: nutritional prevention and intervention. Ther Clin Risk Manag. 2016;12:361-72.
3. Brightling CE, Symon FA, Birring SS, Bradding P, Pavord ID, Wardlaw AJ. TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol. 2002;110(6):899-905.
4. Wang J, Zhou Y, Zhang H, Hu L, Liu J, Wang L, et al. Pathogenesis of allergic diseases and implications for therapeutic interventions. Signal Transduct Target Ther. 2023;8(1):138.
5. Dykewicz MS, Hamilos DL. Rhinitis and sinusitis. J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S103-15.
6. Carneiro BGMC, Petroianu A, Machado JAN, Dos Anjos PMF, da Silva FR, Alberti LR, et al. Clinical and immunological allergy assessment in cancer patients. Sci Rep. 2021;11(1):18110.
7. Fereidouni M, Ferns GA, Bahrami A. Current status and perspectives regarding the association between allergic disorders and cancer. IUBMB Life. 2020;72(7):1322-39.
8. Tirado-Rodríguez B, Huerta-Yépez S. Allergies: diseases closely related to cancer. Bol Med Hosp Infant Mex. 2016;73(6):432-45.
9. Fu SL, Pierre J, Smith-Norowitz TA, Hagler M, Bowne W, Pincus MR, et al. Immunoglobulin E antibodies from pancreatic cancer patients mediate antibody-dependent cell-mediated cytotoxicity against pancreatic cancer cells. Clin Exp Immunol. 2008;153(3):401-9.
10. Heikkilä K, Harris R, Lowe G, Rumley A, Yarnell J, Gallacher J, et al. Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis. Cancer Causes Control. 2009;20(1):15-26.
11. Siemes C, Visser LE, Coebergh JW, Splinter TA, Witteman JC, Uitterlinden AG, et al. C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study. J Clin Oncol. 2006;24(33):5216-22.
12. Profet M. The function of allergy: immunological defense against toxins. Q Rev Biol. 1991;66(1):23-62.
13. Sherman PW, Holland E, Sherman JS. Allergies: their role in cancer prevention. Q Rev Biol. 2008;83(4):339-62.
14. Josephs DH, Spicer JF, Corrigan CJ, Gould HJ, Karagiannis SN. Epidemiological associations of allergy, IgE and cancer. Clin Exp Allergy. 2013;43(10):1110-23.
15. Karim AF, Westenberg LEH, Eurelings LEM, Otten R, Gerth van Wijk R. The association between allergic diseases and cancer: a systematic review of the literature. Neth J Med. 2019;77(2):42-66.
16. Qu YL, Liu J, Zhang LX, Wu CM, Chu AJ, Wen BL, et al. Asthma and the risk of lung cancer: a meta-analysis. Oncotarget. 2017;8(7):11614-20.
17. Barsouk A, Aluru JS, Rawla P, Saginala K, Barsouk A. Epidemiology, risk factors, and prevention of head and neck squamous cell carcinoma. Med Sci (Basel). 2023;11(2):42.
18. Mastronikolis NS, Delides A, Kyrodimos E, Piperigkou Z, Spyropoulou D, Giotakis E, et al. Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles. Mol Biol Rep. 2024;51(1):597.
19. Son E, Panwar A, Mosher CH, Lydiatt D. Cancers of the major salivary gland. J Oncol Pract. 2018;14(2):99-108.
20. Dhull AK, Atri R, Kaushal V, Malik G, Soni A, Dhankhar R, et al. Alcohol as a risk factor in HNC, an enormous toll on the lives and communities. J Evid Based Med Healthc. 2016;3(12):354-60.
21. Dhull AK, Atri R, Dhankhar R, Chauhan AK, Kaushal V. Major risk factors in head and neck cancer: a retrospective analysis of 12-year experiences. World J Oncol. 2018;9(3):80-4.
22. Moradinazar M, Najafi F, Jajilian F, Pasdar Y, Hamzeh B, Shakiba E, et al. Prevalence of drug use, alcohol consumption, cigarette smoking and measure of socioeconomic-related inequalities of drug use among Iranian people: findings from a national survey. Subst Abuse Treat Prev Policy. 2020;15(1):39. PMID: 32503660
23. Singh A, Dikshit R, Chaturvedi P. Betel nut use: the South Asian story. Subst Use Misuse. 2020;55(9):1545-51
24. Lechner M, Liu J, Masterson L, Fenton TR. HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management. Nat Rev Clin Oncol. 2022;19(5):306-27.
25. Su ZY, Siak PY, Leong CO, Cheah SC. The role of Epstein-Barr virus in nasopharyngeal carcinoma. Front Microbiol. 2023;14:1116143.
26. Hsiao JR, Ou CY, Lo HI, Huang CC, Lee WT, Huang JS, et al. Allergies and risk of head and neck cancer: an original study plus meta-analysis. PLoS One. 2013;8(2):e55138.
27. Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021.
28. Harris RJ, Deeks JJ, Altman DG, Bradburn MJ, Harbord RM, Sterne JAC. Metan: fixed- and random-effects meta-analysis. Stata J. 2008;8(1):3-28.
29. Wang W, Shan G. Exact confidence intervals for the relative risk and the odds ratio. Biometrics. 2015;71(4):985-95.
30. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60.
31. Sterne JA, Egger M, Smith GD. Systematic reviews in health care: investigating and dealing with publication and other biases in meta-analysis. BMJ. 2001;323(7304):101-5.
32. Egger M, Davey-Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629-34.
33. Spineli LM, Pandis N. Prediction interval in random-effects meta-analysis. Am J Orthod Dentofacial Orthop. 2020;157(4):586-8.
34. Chung SD, Wu CS, Lin HC, Hung SH. Association between allergic rhinitis and nasopharyngeal carcinoma: a population-based study. Laryngoscope. 2014;124(8):1744-9.
35. D'Arcy M, Rivera DR, Grothen A, Engels EA. Allergies and the subsequent risk of cancer among elderly adults in the United States. Cancer Epidemiol Biomarkers Prev. 2019;28(4):741-50.
36. Engkilde K, Thyssen JP, Menné T, Johansen JD. Association between cancer and contact allergy: a linkage study. BMJ Open. 2011;1(1):e000084.
37. Eriksson NE, Mikoczy Z, Hagmar L. Cancer incidence in 13,811 patients skin tested for allergy. J Investig Allergol Clin Immunol. 2005;15(3):161-6.
38. Fekrazad S, Mohebbi E, Mehravar S, Mortaja M, Teymouri F, Hadji M, et al. Allergies and risk of head and neck cancer: a case-control study. Sci Rep. 2024;14(1):15006.
39. Filippidis FT, Schwartz SM, Becker N, Dyckhoff G, Kirschfink M, Dietz A, et al. Association of history of allergies and influenza-like infections with laryngeal cancer in a case-control study. Eur Arch Otorhinolaryngol. 2015;272(8):2063-9.
40. Guo Y, Bian J, Chen Z, Fishe JN, Zhang D, Braithwaite D, et al. Cancer incidence after asthma diagnosis: evidence from a large clinical research network in the United States. Cancer Med. 2023;12(10):11871-7.
41. Hagströmer L, Ye W, Nyrén O, Emtestam L. Incidence of cancer among patients with atopic dermatitis. Arch Dermatol. 2005;141(9):1123-7.
42. Hemminki K, Försti A, Fallah M, Sundquist J, Sundquist K, Ji J. Risk of cancer in patients with medically diagnosed hay fever or allergic rhinitis. Int J Cancer. 2014;135(10):2397-403.
43. Hwang CY, Chen YJ, Lin MW, Chen TJ, Chu SY, Chen CC, et al. Cancer risk in patients with allergic rhinitis, asthma and atopic dermatitis: a nationwide cohort study in Taiwan. Int J Cancer. 2012;130(5):1160-7.
44. Ji J, Shu X, Li X, Sundquist K, Sundquist J, Hemminki K. Cancer risk in hospitalised asthma patients. Br J Cancer. 2009;100(5):829-33
45. Liao HC, Wu SY, Ou CY, Hsiao JR, Huang JS, Tsai ST, et al. Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer. Cancer Causes Control. 2016;27(9):1105-15
46. Lin KT, Huang WY, Lin CC, Jen YM, Lin CS, Lo CH, et al. Subsequent risk of nasopharyngeal carcinoma among patients with allergic rhinitis: a nationwide population-based cohort study. Head Neck. 2015;37(3):413-7.
47. Liu X, Hemminki K, Försti A, Sundquist J, Sundquist K, Ji J. Cancer risk and mortality in asthma patients: A Swedish national cohort study. Acta Oncol. 2015;54(8):1120-7.
48. Michaud DS, Langevin SM, Eliot M, Nelson HH, McClean MD, Christensen BC, et al. Allergies and risk of head and neck cancer. Cancer Causes Control. 2012;23(8):1317-22.
49. Petroianu A, Chaves DN, De Oliveira O Jr. Comparative incidence of allergy in the presence or absence of cancer. J Int Med Res. 1995;23(5):358-63.
50. Polednak A. Asthma and cancer mortality. The lancet. 1975;306(7945):1147-8.
51. Skaaby T, Nystrup Husemoen LL, Roswall N, Thuesen BH, Linneberg A. Atopy and development of cancer: a population-based prospective study. J Allergy Clin Immunol Pract. 2014;2(6):779-85.
52. Stott-Miller M, Chen C, Doody DR, Carter JL, Galloway DA, Madeleine MM et al. A history of allergies is associated with reduced risk of oral squamous cell carcinoma. Cancer Causes Control. 2012;23(12):1911-9.
53. Vena JE, Bona JR, Byers TE, Middleton E Jr, Swanson MK, Graham S. Allergy-related diseases and cancer: an inverse association. Am J Epidemiol. 1985;122(1):66-74.
54. Bosetti C, Talamini R, Franceschi S, Negri E, Giacosa A, La Vecchia C. Allergy and the risk of selected digestive and laryngeal neoplasms. Eur J Cancer Prev. 2004;13(3):173-6.
55. Vesterinen E, Pukkala E, Timonen T, Aromaa A. Cancer incidence among 78,000 asthmatic patients. Int J Epidemiol. 1993;22(6):976-82.
56. Robinette CD, Fraumeni JF Jr. Asthma and subsequent mortality in World War II veterans. J Chronic Dis. 1978;31(9-10):619-24.
57. Källén B, Gunnarskog J, Conradson TB. Cancer risk in asthmatic subjects selected from hospital discharge registry. Eur Respir J. 1993;6(5):694-7.
58. Xiao X, Zhang Z, Chang ET, Liu Z, Liu Q, Cai Y et al. Medical History, Medication Use, and Risk of Nasopharyngeal Carcinoma. Am J Epidemiol. 2018;187(10):2117-25.
59. Beachler DC, Engels EA. Chronic Sinusitis and Risk of Head and Neck Cancer in the US Elderly Population. JAMA Otolaryngol Head Neck Surg. 2017;143(1):25-31.
60. Hung SH, Chen PY, Lin HC, Ting J, Chung SD. Association of rhinosinusitis with nasopharyngeal carcinoma: a population-based study. Laryngoscope. 2014;124(7):1515-20.
61. Al-Anazi AE, Alanazi BS, Alshanbari HM, Masuadi E, Hamed ME, Dandachi I, et al. Increased Prevalence of EBV Infection in Nasopharyngeal Carcinoma Patients: A Six-Year Cross-Sectional Study. Cancers (Basel). 2023;15(3):643.
62. Bickham K, Münz C, Tsang ML, Larsson M, Fonteneau JF, Bhardwaj N, et al. EBNA1-specific CD4+ T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function. J Clin Invest. 2001;107(1):121-30.
63. Chouinard E, Walter S. Recall bias in case-control studies: an empirical analysis and theoretical framework. J Clin Epidemiol. 1995;48(2):245-54.
64. Sterne JA, Sutton AJ, Ioannidis JP, Terrin N, Jones DR, Lau J, et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ. 2011;343: d4002.
65. Sekula P, Del Greco MF, Pattaro C, Köttgen A. Mendelian Randomization as an Approach to Assess Causality Using Observational Data. J Am Soc Nephrol. 2016;27(11):3253-65.
66. Markov SD, Caffrey TC, O'Connell KA, Grunkemeyer JA, Shin S, Hanson R, et al. IgE-Based Therapeutic Combination Enhances Antitumor Response in Preclinical Models of Pancreatic Cancer. Mol Cancer Ther. 2021;20(12):2457-68
67. Spicer J, Basu B, Montes A, Banerji U, Kristeleit R, Miller R, et al. Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial. Nat Commun. 2023;14(1):4180.
2. Hendaus MA, Jomha FA, Ehlayel M. Allergic diseases among children: nutritional prevention and intervention. Ther Clin Risk Manag. 2016;12:361-72.
3. Brightling CE, Symon FA, Birring SS, Bradding P, Pavord ID, Wardlaw AJ. TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol. 2002;110(6):899-905.
4. Wang J, Zhou Y, Zhang H, Hu L, Liu J, Wang L, et al. Pathogenesis of allergic diseases and implications for therapeutic interventions. Signal Transduct Target Ther. 2023;8(1):138.
5. Dykewicz MS, Hamilos DL. Rhinitis and sinusitis. J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S103-15.
6. Carneiro BGMC, Petroianu A, Machado JAN, Dos Anjos PMF, da Silva FR, Alberti LR, et al. Clinical and immunological allergy assessment in cancer patients. Sci Rep. 2021;11(1):18110.
7. Fereidouni M, Ferns GA, Bahrami A. Current status and perspectives regarding the association between allergic disorders and cancer. IUBMB Life. 2020;72(7):1322-39.
8. Tirado-Rodríguez B, Huerta-Yépez S. Allergies: diseases closely related to cancer. Bol Med Hosp Infant Mex. 2016;73(6):432-45.
9. Fu SL, Pierre J, Smith-Norowitz TA, Hagler M, Bowne W, Pincus MR, et al. Immunoglobulin E antibodies from pancreatic cancer patients mediate antibody-dependent cell-mediated cytotoxicity against pancreatic cancer cells. Clin Exp Immunol. 2008;153(3):401-9.
10. Heikkilä K, Harris R, Lowe G, Rumley A, Yarnell J, Gallacher J, et al. Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis. Cancer Causes Control. 2009;20(1):15-26.
11. Siemes C, Visser LE, Coebergh JW, Splinter TA, Witteman JC, Uitterlinden AG, et al. C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study. J Clin Oncol. 2006;24(33):5216-22.
12. Profet M. The function of allergy: immunological defense against toxins. Q Rev Biol. 1991;66(1):23-62.
13. Sherman PW, Holland E, Sherman JS. Allergies: their role in cancer prevention. Q Rev Biol. 2008;83(4):339-62.
14. Josephs DH, Spicer JF, Corrigan CJ, Gould HJ, Karagiannis SN. Epidemiological associations of allergy, IgE and cancer. Clin Exp Allergy. 2013;43(10):1110-23.
15. Karim AF, Westenberg LEH, Eurelings LEM, Otten R, Gerth van Wijk R. The association between allergic diseases and cancer: a systematic review of the literature. Neth J Med. 2019;77(2):42-66.
16. Qu YL, Liu J, Zhang LX, Wu CM, Chu AJ, Wen BL, et al. Asthma and the risk of lung cancer: a meta-analysis. Oncotarget. 2017;8(7):11614-20.
17. Barsouk A, Aluru JS, Rawla P, Saginala K, Barsouk A. Epidemiology, risk factors, and prevention of head and neck squamous cell carcinoma. Med Sci (Basel). 2023;11(2):42.
18. Mastronikolis NS, Delides A, Kyrodimos E, Piperigkou Z, Spyropoulou D, Giotakis E, et al. Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles. Mol Biol Rep. 2024;51(1):597.
19. Son E, Panwar A, Mosher CH, Lydiatt D. Cancers of the major salivary gland. J Oncol Pract. 2018;14(2):99-108.
20. Dhull AK, Atri R, Kaushal V, Malik G, Soni A, Dhankhar R, et al. Alcohol as a risk factor in HNC, an enormous toll on the lives and communities. J Evid Based Med Healthc. 2016;3(12):354-60.
21. Dhull AK, Atri R, Dhankhar R, Chauhan AK, Kaushal V. Major risk factors in head and neck cancer: a retrospective analysis of 12-year experiences. World J Oncol. 2018;9(3):80-4.
22. Moradinazar M, Najafi F, Jajilian F, Pasdar Y, Hamzeh B, Shakiba E, et al. Prevalence of drug use, alcohol consumption, cigarette smoking and measure of socioeconomic-related inequalities of drug use among Iranian people: findings from a national survey. Subst Abuse Treat Prev Policy. 2020;15(1):39. PMID: 32503660
23. Singh A, Dikshit R, Chaturvedi P. Betel nut use: the South Asian story. Subst Use Misuse. 2020;55(9):1545-51
24. Lechner M, Liu J, Masterson L, Fenton TR. HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management. Nat Rev Clin Oncol. 2022;19(5):306-27.
25. Su ZY, Siak PY, Leong CO, Cheah SC. The role of Epstein-Barr virus in nasopharyngeal carcinoma. Front Microbiol. 2023;14:1116143.
26. Hsiao JR, Ou CY, Lo HI, Huang CC, Lee WT, Huang JS, et al. Allergies and risk of head and neck cancer: an original study plus meta-analysis. PLoS One. 2013;8(2):e55138.
27. Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021.
28. Harris RJ, Deeks JJ, Altman DG, Bradburn MJ, Harbord RM, Sterne JAC. Metan: fixed- and random-effects meta-analysis. Stata J. 2008;8(1):3-28.
29. Wang W, Shan G. Exact confidence intervals for the relative risk and the odds ratio. Biometrics. 2015;71(4):985-95.
30. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60.
31. Sterne JA, Egger M, Smith GD. Systematic reviews in health care: investigating and dealing with publication and other biases in meta-analysis. BMJ. 2001;323(7304):101-5.
32. Egger M, Davey-Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629-34.
33. Spineli LM, Pandis N. Prediction interval in random-effects meta-analysis. Am J Orthod Dentofacial Orthop. 2020;157(4):586-8.
34. Chung SD, Wu CS, Lin HC, Hung SH. Association between allergic rhinitis and nasopharyngeal carcinoma: a population-based study. Laryngoscope. 2014;124(8):1744-9.
35. D'Arcy M, Rivera DR, Grothen A, Engels EA. Allergies and the subsequent risk of cancer among elderly adults in the United States. Cancer Epidemiol Biomarkers Prev. 2019;28(4):741-50.
36. Engkilde K, Thyssen JP, Menné T, Johansen JD. Association between cancer and contact allergy: a linkage study. BMJ Open. 2011;1(1):e000084.
37. Eriksson NE, Mikoczy Z, Hagmar L. Cancer incidence in 13,811 patients skin tested for allergy. J Investig Allergol Clin Immunol. 2005;15(3):161-6.
38. Fekrazad S, Mohebbi E, Mehravar S, Mortaja M, Teymouri F, Hadji M, et al. Allergies and risk of head and neck cancer: a case-control study. Sci Rep. 2024;14(1):15006.
39. Filippidis FT, Schwartz SM, Becker N, Dyckhoff G, Kirschfink M, Dietz A, et al. Association of history of allergies and influenza-like infections with laryngeal cancer in a case-control study. Eur Arch Otorhinolaryngol. 2015;272(8):2063-9.
40. Guo Y, Bian J, Chen Z, Fishe JN, Zhang D, Braithwaite D, et al. Cancer incidence after asthma diagnosis: evidence from a large clinical research network in the United States. Cancer Med. 2023;12(10):11871-7.
41. Hagströmer L, Ye W, Nyrén O, Emtestam L. Incidence of cancer among patients with atopic dermatitis. Arch Dermatol. 2005;141(9):1123-7.
42. Hemminki K, Försti A, Fallah M, Sundquist J, Sundquist K, Ji J. Risk of cancer in patients with medically diagnosed hay fever or allergic rhinitis. Int J Cancer. 2014;135(10):2397-403.
43. Hwang CY, Chen YJ, Lin MW, Chen TJ, Chu SY, Chen CC, et al. Cancer risk in patients with allergic rhinitis, asthma and atopic dermatitis: a nationwide cohort study in Taiwan. Int J Cancer. 2012;130(5):1160-7.
44. Ji J, Shu X, Li X, Sundquist K, Sundquist J, Hemminki K. Cancer risk in hospitalised asthma patients. Br J Cancer. 2009;100(5):829-33
45. Liao HC, Wu SY, Ou CY, Hsiao JR, Huang JS, Tsai ST, et al. Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer. Cancer Causes Control. 2016;27(9):1105-15
46. Lin KT, Huang WY, Lin CC, Jen YM, Lin CS, Lo CH, et al. Subsequent risk of nasopharyngeal carcinoma among patients with allergic rhinitis: a nationwide population-based cohort study. Head Neck. 2015;37(3):413-7.
47. Liu X, Hemminki K, Försti A, Sundquist J, Sundquist K, Ji J. Cancer risk and mortality in asthma patients: A Swedish national cohort study. Acta Oncol. 2015;54(8):1120-7.
48. Michaud DS, Langevin SM, Eliot M, Nelson HH, McClean MD, Christensen BC, et al. Allergies and risk of head and neck cancer. Cancer Causes Control. 2012;23(8):1317-22.
49. Petroianu A, Chaves DN, De Oliveira O Jr. Comparative incidence of allergy in the presence or absence of cancer. J Int Med Res. 1995;23(5):358-63.
50. Polednak A. Asthma and cancer mortality. The lancet. 1975;306(7945):1147-8.
51. Skaaby T, Nystrup Husemoen LL, Roswall N, Thuesen BH, Linneberg A. Atopy and development of cancer: a population-based prospective study. J Allergy Clin Immunol Pract. 2014;2(6):779-85.
52. Stott-Miller M, Chen C, Doody DR, Carter JL, Galloway DA, Madeleine MM et al. A history of allergies is associated with reduced risk of oral squamous cell carcinoma. Cancer Causes Control. 2012;23(12):1911-9.
53. Vena JE, Bona JR, Byers TE, Middleton E Jr, Swanson MK, Graham S. Allergy-related diseases and cancer: an inverse association. Am J Epidemiol. 1985;122(1):66-74.
54. Bosetti C, Talamini R, Franceschi S, Negri E, Giacosa A, La Vecchia C. Allergy and the risk of selected digestive and laryngeal neoplasms. Eur J Cancer Prev. 2004;13(3):173-6.
55. Vesterinen E, Pukkala E, Timonen T, Aromaa A. Cancer incidence among 78,000 asthmatic patients. Int J Epidemiol. 1993;22(6):976-82.
56. Robinette CD, Fraumeni JF Jr. Asthma and subsequent mortality in World War II veterans. J Chronic Dis. 1978;31(9-10):619-24.
57. Källén B, Gunnarskog J, Conradson TB. Cancer risk in asthmatic subjects selected from hospital discharge registry. Eur Respir J. 1993;6(5):694-7.
58. Xiao X, Zhang Z, Chang ET, Liu Z, Liu Q, Cai Y et al. Medical History, Medication Use, and Risk of Nasopharyngeal Carcinoma. Am J Epidemiol. 2018;187(10):2117-25.
59. Beachler DC, Engels EA. Chronic Sinusitis and Risk of Head and Neck Cancer in the US Elderly Population. JAMA Otolaryngol Head Neck Surg. 2017;143(1):25-31.
60. Hung SH, Chen PY, Lin HC, Ting J, Chung SD. Association of rhinosinusitis with nasopharyngeal carcinoma: a population-based study. Laryngoscope. 2014;124(7):1515-20.
61. Al-Anazi AE, Alanazi BS, Alshanbari HM, Masuadi E, Hamed ME, Dandachi I, et al. Increased Prevalence of EBV Infection in Nasopharyngeal Carcinoma Patients: A Six-Year Cross-Sectional Study. Cancers (Basel). 2023;15(3):643.
62. Bickham K, Münz C, Tsang ML, Larsson M, Fonteneau JF, Bhardwaj N, et al. EBNA1-specific CD4+ T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function. J Clin Invest. 2001;107(1):121-30.
63. Chouinard E, Walter S. Recall bias in case-control studies: an empirical analysis and theoretical framework. J Clin Epidemiol. 1995;48(2):245-54.
64. Sterne JA, Sutton AJ, Ioannidis JP, Terrin N, Jones DR, Lau J, et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ. 2011;343: d4002.
65. Sekula P, Del Greco MF, Pattaro C, Köttgen A. Mendelian Randomization as an Approach to Assess Causality Using Observational Data. J Am Soc Nephrol. 2016;27(11):3253-65.
66. Markov SD, Caffrey TC, O'Connell KA, Grunkemeyer JA, Shin S, Hanson R, et al. IgE-Based Therapeutic Combination Enhances Antitumor Response in Preclinical Models of Pancreatic Cancer. Mol Cancer Ther. 2021;20(12):2457-68
67. Spicer J, Basu B, Montes A, Banerji U, Kristeleit R, Miller R, et al. Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial. Nat Commun. 2023;14(1):4180.
| Files | ||
| Issue | Articles in Press | |
| Section | Review Article(s) | |
| Keywords | ||
| Allergies Association Head and neck cancer Meta-analysis Nasopharynx Systematic review | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Saber A, Karlsson D. Allergic Diseases and Head and Neck Cancer: A Systematic Review and Meta-analysis. Iran J Allergy Asthma Immunol. 2025;:1-16.
