Measurement of the Neutrophils Count and Oxidative Burst in Neutrophils of Patients with Sanjad Sakati Syndrome
-
Farhad Abolnezhadian
,
Majid Aminzadeh
,
Sara Iranparast
,
Sajad Dehnavi
,
Fatemeh Dousti
,
Moosa Sharifat
,
Hamid Moradzadegan
Abstract
Sanjad Sakati Syndrome (SSS) is categorized as a neuroendocrine-related disease due to disorders of the nervous and hormonal systems. Since hormonal changes in these patients may affect the nature and function of the immune system. Thus, in this study, cell count and phagocytotic function of neutrophils were evaluated which may be influenced by changes in the hormonal rate and growth factors.
In this study, the neutrophil count value and the oxidative burst were evaluated in six patients diagnosed with SSS and six healthy individuals.
There was a significant reduction in the neutrophil count observed in SSS patients compared to healthy controls (37.41±7.93 percent vs. 66.5±6.8 percent). However, there was no significant difference in neutrophil oxidative index between patients with SSS and control subjects (172.33±55.08 vs. 217.00±77.38).
We concluded that in patients with SSS, the phagocytic activity of neutrophils was not affected by hormonal changes, while the number of neutrophils and neutrophil-to-lymphocyte ratio (NLR) index were decreased.
1. Sanjad S, Sakati N, Abu-Osba Y. Congenital hypoparathyroidism with dysmorphic features: a new syndrome. Pediatr Res. 1988;23(3):271A.
2. Kelly TE, Blanton S, Saif R, Sanjad SA, Sakati NA. Confirmation of the assignment of the Sanjad-Sakati (congenital hypoparathyroidism) syndrome (OMIM 241410) locus to chromosome 1q42-43. J Med Genet. 2000;37(1):63-4.
3. Parvari R, Hershkovitz E, Grossman N, Gorodischer R, Loeys B, Zecic A, et al. Mutation of TBCE causes hypoparathyroidism–retardation–dysmorphism and autosomal recessive Kenny–Caffey syndrome. Nat Genet. 2002;32(3).
4. Unger S, Górna MW, Le Béchec A, Do Vale-Pereira S, Bedeschi MF, Geiberger S, et al. FAM111A mutations result in hypoparathyroidism and impaired skeletal development. Am J Hum Genet. 2013;92(6):990-5.
5. Sabry M, Zaki M, Hassan SA, Ramadan D, Rasool MA, Al Awadi S, et al. Kenny-Caffey syndrome is part of the CATCH 22 haploinsufficiency cluster. J Med Genet. 1998;35(1):31-6.
6. Sanjad S, Sakati NA, Abu-Osba Y, Kaddoura R, Milner R. A new syndrome of congenital hypoparathyroidism, severe growth failure, and dysmorphic features. Arch Dis Child. 1991;66(2):193-6.
7. Naguib K, Gouda S, Elshafey A, Mohammed F, Bastaki L, Azab A, et al. Sanjad-Sakati syndrome/Kenny-Caffey syndrome type 1: a study of 21 cases in Kuwait. EMHJ-East Mediterr Health J. 2009;15(2):345-52.
8. Al-Malik M. The dentofacial features of Sanjad–Sakati syndrome: a case report. Int J Paediatr Dent. 2004;14(2):136-40.
9. Elhassanien AF, Alghaiaty HA-A. Neurological manifestations in children with Sanjad–Sakati syndrome. Int J Gen Med. 2013;6:393.
10. Haider AS, Ganesh A, Al-Kindi A, Al-Hinai A, Al-Kharousi N, Al-Yaroubi S, et al. New ocular associations in Sanjad-Sakati syndrome: Case report from Oman. Sultan Qaboos Univ Med J. 2014;14(3):e401.
11. Segal AW. How neutrophils kill microbes. Annu Rev Immunol. 2005;23:197-223.
12. Motoc NS, Martinovici P, Boca BM, Tudorache IS, Harsovescu T, Furtunescu FL, et al. Neutrophil-to-lymphocyte ratio (NLR) and Platelets-to-lymphocyte (PLR) Ratio in Patients with Exacerbation of Bronchiectasis. Rev Chim. 2019;70:3889-92.
13. Motoc NS, Man MA, Urda AEC, Ruta VM, Todea DA, Pop CM. Neutrophil-to-Lymphocyte Ratio and Platelets-to-Lymphocytes Ratio in severe COPD exacerbation: The importance of obstructive sleep apnea. In: Eur Respir Soc; 2019.
14. Liu L, Wei Q, Lin Q, Fang J, Wang H, Kwok H, et al. Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection. JCI Insight. 2019;4(4).
15. Yousef AM, Alkhiary W. Role of neutrophil to lymphocyte ratio in prediction of acute exacerbation of chronic obstructive pulmonary disease. Egypt J Chest Dis Tuberc. 2017;66(1):43-8.
16. Alhussien MN, Dang AK. Interaction between stress hormones and phagocytic cells and its effect on the health status of dairy cows: A review. Vet World. 2020;13(9):1837.
17. Hattori N, Saito T, Yagyu T, Jiang B-H, Kitagawa K, Inagaki C. GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils. J Clin Endocrinol Metab. 2001;86(9):4284-91.
18. Sohmiya M, Kanazawa I, Kato Y. Effect of recombinant human GH on circulating granulocyte colony-stimulating factor and neutrophils in patients with adult GH deficiency. Eur J Endocrinol. 2005;152(2):211-5.
19. Akhter MS, Barabutis N. Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone‐releasing hormone. J Biochem Mol Toxicol. 2021;e22879. [Note: Volume and page numbers are missing for this reference. Please provide them for accurate conversion.]
20. Cheng C-H, Liang H-Y, Guo Z-X, Wang A-L, Ye C-X. Effect of Dietary Vitamin C on Growth Performance, Antioxidant Status and Innate Immunity of Juvenile Pufferfish. Isr J Aquacult Bamidgeh. 2017;69.
21. van der Spek AH, Fliers E, Boelen A. Thyroid hormone metabolism in innate immune cells. J Endocrinol. 2017;232(2):R67-81.
22. Marino F, Guasti L, Cosentino M, De Piazza D, Simoni C, Piantanida E, et al. Thyroid hormone regulation of cell migration and oxidative metabolism in polymorphonuclear leukocytes: clinical evidence in thyroidectomized subjects on thyroxine replacement therapy. Life Sci. 2006;78(10):1071-7.
23. Russo‐Carbolante E, Polizzelo A, Azzolini A, Maciel L, Lucisano‐Valim Y. Neutrophils from Brazilian patients with Graves' disease: some biochemical and functional aspects. Cell Biochem Funct. 2005;23(5):297-306.
24. Mezosi E, Szabo J, Nagy E, Borbely A, Varga E, Paragh G, et al. Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes. J Endocrinol. 2005;185(1):121-9.
25. Aoyagi K, Takeshige K, Minakami S. Effects of iodothyronines on chemotactic peptide-receptor binding and superoxide production of human neutrophils. Biochim Biophys Acta Mol Cell Res. 1991;1093(2-3):223-8.
26. Videla LA, Correa L, Rivera M, Sir T. Zymosan-induced luminol-amplified chemiluminescence of whole blood phagocytes in experimental and human hyperthyroidism. Free Radic Biol Med. 1993;14(6):669-75.
27. Mohan B, Damodar KS. Functional features of neutrophils in subclinical hypothyroidism compared to euthyroid status: Functional features of neutrophils in subclinical hypothyroidism. Ann Med Physiol. 2019;3(1):3-9.
28. Önalan E, Dönder E. Neutrophil and platelet to lymphocyte ratio in patients with hypothyroid Hashimoto’s thyroiditis. Acta Bio Med Atenei Parm. 2020;91(2):310.
29. Bilge M, Yesilova A, Adas M, Helvaci A. Neutrophil-and platelet-to lymphocyte ratio in patients with euthyroid Hashimoto’s thyroiditis. Exp Clin Endocrinol Diabetes. 2019;127(08):545-9.
2. Kelly TE, Blanton S, Saif R, Sanjad SA, Sakati NA. Confirmation of the assignment of the Sanjad-Sakati (congenital hypoparathyroidism) syndrome (OMIM 241410) locus to chromosome 1q42-43. J Med Genet. 2000;37(1):63-4.
3. Parvari R, Hershkovitz E, Grossman N, Gorodischer R, Loeys B, Zecic A, et al. Mutation of TBCE causes hypoparathyroidism–retardation–dysmorphism and autosomal recessive Kenny–Caffey syndrome. Nat Genet. 2002;32(3).
4. Unger S, Górna MW, Le Béchec A, Do Vale-Pereira S, Bedeschi MF, Geiberger S, et al. FAM111A mutations result in hypoparathyroidism and impaired skeletal development. Am J Hum Genet. 2013;92(6):990-5.
5. Sabry M, Zaki M, Hassan SA, Ramadan D, Rasool MA, Al Awadi S, et al. Kenny-Caffey syndrome is part of the CATCH 22 haploinsufficiency cluster. J Med Genet. 1998;35(1):31-6.
6. Sanjad S, Sakati NA, Abu-Osba Y, Kaddoura R, Milner R. A new syndrome of congenital hypoparathyroidism, severe growth failure, and dysmorphic features. Arch Dis Child. 1991;66(2):193-6.
7. Naguib K, Gouda S, Elshafey A, Mohammed F, Bastaki L, Azab A, et al. Sanjad-Sakati syndrome/Kenny-Caffey syndrome type 1: a study of 21 cases in Kuwait. EMHJ-East Mediterr Health J. 2009;15(2):345-52.
8. Al-Malik M. The dentofacial features of Sanjad–Sakati syndrome: a case report. Int J Paediatr Dent. 2004;14(2):136-40.
9. Elhassanien AF, Alghaiaty HA-A. Neurological manifestations in children with Sanjad–Sakati syndrome. Int J Gen Med. 2013;6:393.
10. Haider AS, Ganesh A, Al-Kindi A, Al-Hinai A, Al-Kharousi N, Al-Yaroubi S, et al. New ocular associations in Sanjad-Sakati syndrome: Case report from Oman. Sultan Qaboos Univ Med J. 2014;14(3):e401.
11. Segal AW. How neutrophils kill microbes. Annu Rev Immunol. 2005;23:197-223.
12. Motoc NS, Martinovici P, Boca BM, Tudorache IS, Harsovescu T, Furtunescu FL, et al. Neutrophil-to-lymphocyte ratio (NLR) and Platelets-to-lymphocyte (PLR) Ratio in Patients with Exacerbation of Bronchiectasis. Rev Chim. 2019;70:3889-92.
13. Motoc NS, Man MA, Urda AEC, Ruta VM, Todea DA, Pop CM. Neutrophil-to-Lymphocyte Ratio and Platelets-to-Lymphocytes Ratio in severe COPD exacerbation: The importance of obstructive sleep apnea. In: Eur Respir Soc; 2019.
14. Liu L, Wei Q, Lin Q, Fang J, Wang H, Kwok H, et al. Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection. JCI Insight. 2019;4(4).
15. Yousef AM, Alkhiary W. Role of neutrophil to lymphocyte ratio in prediction of acute exacerbation of chronic obstructive pulmonary disease. Egypt J Chest Dis Tuberc. 2017;66(1):43-8.
16. Alhussien MN, Dang AK. Interaction between stress hormones and phagocytic cells and its effect on the health status of dairy cows: A review. Vet World. 2020;13(9):1837.
17. Hattori N, Saito T, Yagyu T, Jiang B-H, Kitagawa K, Inagaki C. GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils. J Clin Endocrinol Metab. 2001;86(9):4284-91.
18. Sohmiya M, Kanazawa I, Kato Y. Effect of recombinant human GH on circulating granulocyte colony-stimulating factor and neutrophils in patients with adult GH deficiency. Eur J Endocrinol. 2005;152(2):211-5.
19. Akhter MS, Barabutis N. Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone‐releasing hormone. J Biochem Mol Toxicol. 2021;e22879. [Note: Volume and page numbers are missing for this reference. Please provide them for accurate conversion.]
20. Cheng C-H, Liang H-Y, Guo Z-X, Wang A-L, Ye C-X. Effect of Dietary Vitamin C on Growth Performance, Antioxidant Status and Innate Immunity of Juvenile Pufferfish. Isr J Aquacult Bamidgeh. 2017;69.
21. van der Spek AH, Fliers E, Boelen A. Thyroid hormone metabolism in innate immune cells. J Endocrinol. 2017;232(2):R67-81.
22. Marino F, Guasti L, Cosentino M, De Piazza D, Simoni C, Piantanida E, et al. Thyroid hormone regulation of cell migration and oxidative metabolism in polymorphonuclear leukocytes: clinical evidence in thyroidectomized subjects on thyroxine replacement therapy. Life Sci. 2006;78(10):1071-7.
23. Russo‐Carbolante E, Polizzelo A, Azzolini A, Maciel L, Lucisano‐Valim Y. Neutrophils from Brazilian patients with Graves' disease: some biochemical and functional aspects. Cell Biochem Funct. 2005;23(5):297-306.
24. Mezosi E, Szabo J, Nagy E, Borbely A, Varga E, Paragh G, et al. Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes. J Endocrinol. 2005;185(1):121-9.
25. Aoyagi K, Takeshige K, Minakami S. Effects of iodothyronines on chemotactic peptide-receptor binding and superoxide production of human neutrophils. Biochim Biophys Acta Mol Cell Res. 1991;1093(2-3):223-8.
26. Videla LA, Correa L, Rivera M, Sir T. Zymosan-induced luminol-amplified chemiluminescence of whole blood phagocytes in experimental and human hyperthyroidism. Free Radic Biol Med. 1993;14(6):669-75.
27. Mohan B, Damodar KS. Functional features of neutrophils in subclinical hypothyroidism compared to euthyroid status: Functional features of neutrophils in subclinical hypothyroidism. Ann Med Physiol. 2019;3(1):3-9.
28. Önalan E, Dönder E. Neutrophil and platelet to lymphocyte ratio in patients with hypothyroid Hashimoto’s thyroiditis. Acta Bio Med Atenei Parm. 2020;91(2):310.
29. Bilge M, Yesilova A, Adas M, Helvaci A. Neutrophil-and platelet-to lymphocyte ratio in patients with euthyroid Hashimoto’s thyroiditis. Exp Clin Endocrinol Diabetes. 2019;127(08):545-9.
| Files | ||
| Issue | Vol 23 No 1 (2024) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijaai.v23i1.14959 | |
| Keywords | ||
| Endocrine system Neutrophil Oxidative burst Sanjad sakati syndrome | ||
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How to Cite
1.
Abolnezhadian F, Aminzadeh M, Iranparast S, DehnaviS, Dousti F, Sharifat M, Moradzadegan H. Measurement of the Neutrophils Count and Oxidative Burst in Neutrophils of Patients with Sanjad Sakati Syndrome. Iran J Allergy Asthma Immunol. 2024;23(1):115-121.
