Case Report
  

Food Protein-induced Enterocolitis Syndrome Due to Cuttlefish in a Child with Anaphylaxis to Crustaceans

Abstract

Shellfish is defined as any edible marine invertebrate and refers to crustaceans and mollusks. Crustaceans belong to the phylum Arthropods. Mollusks belong to the phylum Mollusca.
This report illustrates a rare case of a 6-year-old girl with challenge-proven acute food protein–induced enterocolitis syndrome (FPIES) to cuttlefish (phylum Mollusca, class Cephalopoda), anaphylaxis to crustaceans (phylum Arthropoda), and tolerance to other mollusks, including clams and mussels (phylum Mollusca, class Bivalvia). The association of IgE-mediated food allergy and acute FPIES seen in this case is rare.
To our knowledge, this is the first case of FPIES to cuttlefish reported in a child.
This challenge highlights the need for further research into the allergens and mechanisms underpinning FPIES at a molecular level, enabling a better understanding of cross-reactivity patterns and the development of diagnostic and predictive tests to assist in clinical practice.

1. Davis CM, Gupta RS, Aktas ON, et al. Clinical Management of Seafood Allergy. J Allergy Clin Immunol Pract. 2020;8:37–44.
2. Van Hage M, Hamsten C, Valenta R. ImmunoCAP assays: Pros and cons in allergology. J Allergy Clin Immunol. 2017;140(12):974–977.
3. Nowak-Węgrzyn A, Chehade M, Groetch ME, et al. International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol. 2017;139(11):1111-1126.e4.
4. Argiz L, Infante S, Machinena A, et al. Children with acute food protein-induced enterocolitis syndrome from Spain and Italy usually tolerate all other food groups. Clin Exp Allergy. 2021;51(8):1238–1241.
5. Berin MC. Advances in understanding immune mechanisms of food protein–induced enterocolitis syndrome. Ann Allergy, Asthma Immunol. 2021;126:478–481.
6. Sopo SM, Giorgio V, Iacono I Dello, et al. A multicentre retrospective study of 66 Italian children with food protein-induced enterocolitis syndrome: Different management for different phenotypes. Clin Exp Allergy. 2012;42(8):1257–1265.
7. Sopo SM, D’Antuono A, Morganti A, et al. Food protein-induced enterocolitis syndrome due to oysters ingestion. Isr Med Assoc J. 2015;17:188–189.
8. González-Delgado P, Caparrós E, Moreno MV, et al. Clinical and immunological characteristics of a pediatric population with food protein-induced enterocolitis syndrome (FPIES) to fish. Pediatr Allergy Immunol. 2016;27(5):269–275.
9. Du Y (Jennifer), Nowak-Węgrzyn A, Vadas P. FPIES in adults. Ann Allergy, Asthma Immunol. 2018;121:736–738.
10. Tan JA, Smith WB. Non-IgE-mediated gastrointestinal food hypersensitivity syndrome in adults. J Allergy Clin Immunol Pract. 2014;2:355-357.e1.
11. Barni S, Vazquez-Ortiz M, Giovannini M, et al. “Diagnosing food protein-induced enterocolitis syndrome.” Clin Exp Allergy. 2021;51(5):14–28.
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IssueVol 22 No 2 (2023) QRcode
SectionCase Report(s)
DOI https://doi.org/10.18502/ijaai.v22i2.12682
Keywords
Anaphylaxis Cuttlefish Enterocolitis Pediatrics Shellfish
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Barni S, Vazquez-Ortiz M, Giovannini M, Liccioli G, Sarti L, Lascialfari G, Pisano L, Boscia S, Mori F. Food Protein-induced Enterocolitis Syndrome Due to Cuttlefish in a Child with Anaphylaxis to Crustaceans. Iran J Allergy Asthma Immunol. 2023;22(2):208-211.