Anti-inflammatory Effects of Ziziphus Jujube Mill on LPS-induced Acute Lung Injury in Mice
-
Parastoo Shaban
,
Niloofar Honari
,
Nafiseh Erfanian
,
Mehran Hosseini
,
Hossein Safarpour
,
Saeed Nasseri
Abstract
Ziziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J could attenuate lipopolysaccharide (LPS)-induced inflammatory responses in an experimental model of ALI.
Male BALB/c mice received an intratracheal administration of LPS (n=32) or phosphate buffer saline (PBS) (control, n=8). Within 1, 11, and 23 h post-LPS injection, mice were randomly assigned to receive intraperitoneal treatments of saline, dexamethasone (2 mg/kg), and 100 and 200 mg/kg of Z.J extracts, respectively. 24 h after intratracheal administration of LPS, bronchoalveolar lavage fluid and lung tissues were harvested and assessed for inflammatory cell influx, tumor necrosis factor-α (TNF-α) levels, and histological assessments.
Treatment with Z.J extracts (100 and 200 mg/kg) and dexamethasone effectively reduced LPS-induced neutrophil and other inflammatory cell influx into the lung tissue compared to the untreated group. additionally, both doses of Z.J extracts (100 and 200 mg/kg) significantly ameliorated the lung wet-to-dry ratio and histopathological damage. Furthermore, compared to the untreated ALI mice, Z.J extract at the highest dose could significantly reduce the TNF-α level.
The present findings indicated that Z.J could effectively ameliorate LPS-induced ALI inflammatory responses and might be considered a promising alternative therapy for the ALI phenotype.
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22. Gurusamy M, Nasseri S, Lee H, Jung B, Lee D, Khang G, et al. Kinin B1 receptor antagonist BI113823 reduces allergen-induced airway inflammation and mucus secretion in mice. Pharmacol Res. 2016;104:132-9.
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25. An X, Sun X, Hou Y, Yang X, Chen H, Zhang P, et al. Protective effect of oxytocin on LPS-induced acute lung injury in mice. Scientific reports. 2019;9(1):1-11.
26. Han S, Mallampalli RK. The acute respiratory distress syndrome: from mechanism to translation. The Journal of Immunology. 2015;194(3):855-60.
27. Potey PM, Rossi AG, Lucas CD, Dorward DA. Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential. The Journal of pathology. 2019;247(5):672-85.
28. Blázquez-Prieto J, López-Alonso I, Huidobro C, Albaiceta GM. The emerging role of neutrophils in repair after acute lung injury. American journal of respiratory cell and molecular biology. 2018;59(3):289-94.
29. Abraham E. Neutrophils and acute lung injury. Critical care medicine. 2003;31(4):S195-S9.
30. Steinberg KP, Milberg JA, Martin TR, Maunder RJ, Cockrill BA, Hudson LD. Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome. American journal of respiratory and critical care medicine. 1994;150(1):113-22.
31. Ninave PB, Patil SD. Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B.–Possible role in the treatment of asthma. Respiratory physiology & neurobiology. 2019;260:28-36.
32. Manicone AM. Role of the pulmonary epithelium and inflammatory signals in acute lung injury. Expert review of clinical immunology. 2009;5(1):63-75.
33. Mesaik AM, Poh HW, Bin OY, Elawad I, Alsayed B. In vivo anti-inflammatory, anti-bacterial and anti-diarrhoeal activity of Ziziphus Jujuba fruit extract. Open access Macedonian journal of medical sciences. 2018;6(5):757.
34. Li X, Li X, Zhou B, Man S, Gao W, Jing S. Study on the Bioactive Constituents and in vitro Antioxidant and in vivo Anti-inflammatory Activities of Extracts from the Fruits of Ziziphus Jujuba Mill. cv. Jinsixiaozao Hort. Food Science and Technology Research. 2017;23(3):417-26.
35. Cross LM, Matthay MA. Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Critical care clinics. 2011;27(2):355-77.
36. Wang B, Hui Y, Liu L, Zhao A, Chiou Y-S, Zhang F, et al. Optimized extraction of phenolics from jujube peel and their anti-inflammatory effects in LPS-stimulated murine macrophages. Journal of agricultural and food chemistry. 2019;67(6):1666-73.
2. Ware LB, editor Pathophysiology of acute lung injury and the acute respiratory distress syndrome. Seminars in respiratory and critical care medicine; 2006: Citeseer.
3. Feghali CA, Wright TM. Cytokines in acute and chronic inflammation. Front Biosci. 1997;2(1):d12-d26.
4. Fan E, Brodie D, Slutsky AS. Acute respiratory distress syndrome: advances in diagnosis and treatment. Jama. 2018;319(7):698-710.
5. Li J, Lu K, Sun F, Tan S, Zhang X, Sheng W, et al. Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway. J Translati Med. 2021;19(1):1-14.
6. Zarbock A, Ley K. The role of platelets in acute lung injury (ALI). Frontiers in bioscience: a journal and virtual library. 2009;14:150.
7. Lv H, Liu Q, Wen Z, Feng H, Deng X, Ci X. Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis. Redox Biol. 2017;12:311-24.
8. Kim Y, Oh J, Jang CH, Lim JS, Lee JS, Kim J-S. In Vivo Anti-Inflammatory Potential of Viscozyme®-Treated Jujube Fruit. Foods. 2020;9(8):1033.
9. Chen H, Bai C, Wang X. The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine. Exp Rev Res Med. 2010;4(6):773-83.
10. Zhang H-q, Wang H-d, Lu D-x, Qi R-b, Wang Y-p, Yan Y-x, et al. Berberine inhibits cytosolic phospholipase A2 and protects against LPS-induced lung injury and lethality independent of the α2-adrenergic receptor in mice. Shock. 2008;29(5):617-22.
11. Matthay MA WL, Zimmerman GA. The acute respiratory distress syndrome. J Clin Invest. 2012;122:10.
12. Nasseri S, Gurusamy M, Jung B, Lee D, Khang G, Doods H, et al. Kinin B1 receptor antagonist BI113823 reduces acute lung injury. Crit Care Med. 2015;43(11):e499-e507.
13. Cribbs SK, Matthay MA, Martin GS. Stem cells in sepsis and acute lung injury. Crit Care Med. 2010;38(12):2379.
14. Matthay MA, Goolaerts A, Howard JP, Lee JW. Mesenchymal stem cells for acute lung injury: preclinical evidence. Crit Care Med. 2010;38(10 Suppl):S569.
15. Li Y, Guo S, Ren Q, Wei D, Zhao M, Su S, et al. Pharmacokinetic Comparisons of Multiple Triterpenic Acids from Jujubae Fructus Extract Following Oral Delivery in Normal and Acute Liver Injury Rats. Int J Mol Sci. 2018;19(7):2047.
16. Vahedi F, Najafi MF, Bozari K. Evaluation of inhibitory effect and apoptosis induction of Zyzyphus Jujube on tumor cell lines, an in vitro preliminary study. Cytotechnology. 2008;56(2):105-11.
17. Goyal R, Sharma PL, Singh M. Possible attenuation of nitric oxide expression in anti-inflammatory effect of Ziziphus jujuba in rat. J Nat Med. 2011;65(3-4):514-8.
18. Abedini MR, Erfanian N, Nazem H, Jamali S, Hoshyar R. Anti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells. Avicenna journal of phytomedicine. 2016;6(2):142.
19. Gao QH, Wu CS, Wang M. The jujube (Ziziphus jujuba Mill.) fruit: a review of current knowledge of fruit composition and health benefits. Journal of agricultural and food chemistry. 2013;61(14):3351-63.
20. Naik SR, Bhagat S, Shah PD, Tare AA, Ingawale D, Wadekar RR. Evaluation of anti-allergic and anti-anaphylactic activity of ethanolic extract of Zizyphus jujuba fruits in rodents. Revista Brasileira de Farmacognosia. 2013;23(5):811-8.
21. Honari N, Shaban P, Nasseri S, Hosseini M. Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice. J Complementary Integrative Med. 2021.
22. Gurusamy M, Nasseri S, Lee H, Jung B, Lee D, Khang G, et al. Kinin B1 receptor antagonist BI113823 reduces allergen-induced airway inflammation and mucus secretion in mice. Pharmacol Res. 2016;104:132-9.
23. Oishi H, Takano K-i, Tomita K, Takebe M, Yokoo H, Yamazaki M, et al. Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2012;303(2):L130-L40.
24. Gurusamy M, Nasseri S, Rampa DR, Feng H, Lee D, Pekcec A, et al. Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice. Journal of translational medicine. 2021;19(1):1-11.
25. An X, Sun X, Hou Y, Yang X, Chen H, Zhang P, et al. Protective effect of oxytocin on LPS-induced acute lung injury in mice. Scientific reports. 2019;9(1):1-11.
26. Han S, Mallampalli RK. The acute respiratory distress syndrome: from mechanism to translation. The Journal of Immunology. 2015;194(3):855-60.
27. Potey PM, Rossi AG, Lucas CD, Dorward DA. Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential. The Journal of pathology. 2019;247(5):672-85.
28. Blázquez-Prieto J, López-Alonso I, Huidobro C, Albaiceta GM. The emerging role of neutrophils in repair after acute lung injury. American journal of respiratory cell and molecular biology. 2018;59(3):289-94.
29. Abraham E. Neutrophils and acute lung injury. Critical care medicine. 2003;31(4):S195-S9.
30. Steinberg KP, Milberg JA, Martin TR, Maunder RJ, Cockrill BA, Hudson LD. Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome. American journal of respiratory and critical care medicine. 1994;150(1):113-22.
31. Ninave PB, Patil SD. Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B.–Possible role in the treatment of asthma. Respiratory physiology & neurobiology. 2019;260:28-36.
32. Manicone AM. Role of the pulmonary epithelium and inflammatory signals in acute lung injury. Expert review of clinical immunology. 2009;5(1):63-75.
33. Mesaik AM, Poh HW, Bin OY, Elawad I, Alsayed B. In vivo anti-inflammatory, anti-bacterial and anti-diarrhoeal activity of Ziziphus Jujuba fruit extract. Open access Macedonian journal of medical sciences. 2018;6(5):757.
34. Li X, Li X, Zhou B, Man S, Gao W, Jing S. Study on the Bioactive Constituents and in vitro Antioxidant and in vivo Anti-inflammatory Activities of Extracts from the Fruits of Ziziphus Jujuba Mill. cv. Jinsixiaozao Hort. Food Science and Technology Research. 2017;23(3):417-26.
35. Cross LM, Matthay MA. Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Critical care clinics. 2011;27(2):355-77.
36. Wang B, Hui Y, Liu L, Zhao A, Chiou Y-S, Zhang F, et al. Optimized extraction of phenolics from jujube peel and their anti-inflammatory effects in LPS-stimulated murine macrophages. Journal of agricultural and food chemistry. 2019;67(6):1666-73.
| Files | ||
| Issue | Vol 22 No 3 (2023) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijaai.v22i3.13056 | |
| Keywords | ||
| Acute lung injury Inflammation Lipopolysaccharides Ziziphus | ||
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How to Cite
1.
Shaban P, Honari N, Erfanian N, Hosseini M, Safarpour H, Nasseri S. Anti-inflammatory Effects of Ziziphus Jujube Mill on LPS-induced Acute Lung Injury in Mice. Iran J Allergy Asthma Immunol. 2023;22(3):281-289.
