Association of Angiotensin-converting Enzyme Gene Polymorphism with Susceptibility to Asthma Disease in Western Iran
-
Ali Moini
,
Mohammad Reza Khirehgesh
,
Amir Sarkhosh
,
Atena Godarzi
,
Asad Vaisi-Raygani
,
Amir Kiani
Abstract
Asthma is a complex disease caused by a combination of multiple genetic and environmental factors. Angiotensin-converting enzyme (ACE) is involved in the pathogenesis of asthma by inactivating bradykinin, substance P, and neurokinin A. It has been shown that the level of ACE variation in serum is associated with an insertion-deletion (I/D) polymorphism. So, this study aimed to investigate the association of these polymorphisms with asthma in western Iran.
In this case-control study, 111 asthmatic patients as a case group and 80 healthy subjects as a control group were evaluated. The ACE gene polymorphism was determined by the PCR method. The relationship between genotypes done by the χ2 test and the relative risk of disease with genetic polymorphism (Odds Ratio) was performed using logistic regression.
The frequency of I/D genotypes (included in II, ID, and DD) between patient and control groups had no significant difference. In addition, none of the genotypes in the patient and control groups show any significant differences between men and women. However, the frequency of ID and DD genotypes was considerably different between the male patient groups (over and under 40 years old). Hence, these genotypes are suggested to be a risk factor for asthma.
The results of our study indicate that ACE gene polymorphism is not significantly associated with asthma in the west of Iran.
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11. Kuba K, Imai Y, Penninger JM. Angiotensin-converting enzyme 2 in lung diseases. Curr Opinion Pharmacol. 2006;6(3):271-6.
12. Kaur P, Muthuraman A, Kaur M. The implications of angiotensin-converting enzymes and their modulators in neurodegenerative disorders: current and future perspectives. ACS Chem Neurosci. 2015;6(4):508-21.
13. Karamyan VT. Between two storms, vasoactive peptides or bradykinin underlie severity of COVID-19? Physiol Rep. 2021;9(5):e14796.
14. Benigni A, Cassis P, Remuzzi G. Angiotensin II revisited: new roles in inflammation, immunology and aging. EMBO Mol Med. 2010;2(7):247-57.
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16. Sayed-Tabatabaei FA, Oostra BA, Isaacs A, Duijn CMv, Witteman JCM. ACEPolymorphisms.Circ Res. 2006;98(9):1123-33.
17. Han SY, Kwon YJ, Jo SK, Shin JH, Cha DR, Cho WY, et al. ACE gene polymorphism and renal responsiveness to ACE inhibitors in IgA nephropathy patients. Korean J Intern Med. 2000;15(1):13-8.
18. Dorudinia A, Shamaei M, Karimi S, Javadi A, Mohammadi Ziazi L, Pourabdollah M. Evaluation of in-house polymerase chain reaction assay sensitivity, can it be utilized in limited-resources settings? Med J Islam Repub Iran. 2014;28:126.
19. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990;86(4):1343-6.
20. Xu G, Fan G, Sun Y, Yu L, Wu S, Niu W. Association of angiotensin-converting enzyme gene I/D polymorphism with chronic obstructive pulmonary disease: a meta-analysis. J Renin Angiotensin Aldosterone Syst. 2018;19(2):1470320318770546.
21. Ding QL, Sun SF, Cao C, Deng ZC. Association between angiotensin-converting enzyme I/D polymorphism and asthma risk: a meta-analysis involving 11,897 subjects. J Asthma. 2012;49(6):557-62.
22. Zhang YG, Li XB, Zhang J, Huang J, He C, Tian C, et al. The I/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis. Allergy. 2011;66(2):197-205.
23. Chagani T, Paré PD, Zhu S, Weir TD, Bai TR, Behbehani NA, et al. Prevalence of tumor necrosis factor-alpha and angiotensin converting enzyme polymorphisms in mild/moderate and fatal/near-fatal asthma. Am J Respir Crit Care Med. 1999;160(1):278-82.
24. El-Shafei MS, Farres MN, Shahin RY. Evaluation of angiotensin converting enzyme gene polymorphism and susceptibility to bronchial asthma among Egyptians. Allergol Immunopathol (Madr). 2012;40(5):275-80.
25. Eryüksel E, Ceyhan BB, Bircan R, Avşar M, Cirakoğlu B. Angiotensin converting enzyme gene polymorphism in Turkish asthmatic patients. J Asthma. 2009;46(4):335-8.
26. Tomita H, Sato S, Matsuda R, Ogisu N, Mori T, Niimi T, et al. Genetic polymorphism of the angiotensin-converting enzyme (ACE) in asthmatic patients. Resp Med. 1998;92(12):1305-10.
27. Urhan M, Degirmenci I, Harmanci E, Gunes HV, Metintas M, Basaran A. High frequency of DD polymorphism of the angiotensin-converting enzyme gene in Turkish asthmatic patients. Allergy Asthma Proc. 2004;25(4):243-7.
28. Nakahama H, Obata K, Nakajima T, Nakamura H, Kitada O, Sugita M, et al. Renin-angiotensin system component gene polymorphism in Japanese bronchial asthma patients. J Asthma. 1999;36(2):187-93.
29. Cortez M, Matos A, Ferreira J, Lopes L, Gil A, Bicho M. ACE polymorphism in asthmatic patients. Clin Trans Allergy. 2013;3(1):P14.
30. Gao J, Lin Y, Xiao Y, Xu K, Xu W, Zhu Y, et al. Polymorphism of angiotensin-converting enzyme gene and genetic susceptibility to asthma with familial aggregation. Chin Med Sci J. 2000;15(1):24-8.
31. Eleni S, Dimitrios K, Vaya P, Areti M, Norma V, Magdalini G. Angiotensin-I converting enzyme gene and I/D polymorphism distribution in the Greek population and a comparison with other European populations. J Genet. 2008;87(1):91-3.
2. Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CI, et al. Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med. 1995;333(14):894-900.
3. Tillie-Leblond I, Montani D, Crestani B, De Blic J, Humbert M, Tunon-de-Lara M, et al. Relation between inflammation and symptoms in asthma. Allergy. 2009;64(3):354-67.
4. Johansson H, Mersha TB, Brandt EB, Khurana Hershey GK. Interactions between environmental pollutants and genetic susceptibility in asthma risk. Curr Opin Immunol. 2019;60(14):156-62.
5. Alizadeh-Navaei R, Rafiei A, Hedayatizadeh-Omran A, Mohammadzadeh I, Arabi M. Gene susceptibility in Iranian asthmatic patients: a narrative review. Ann Med Health Sci Res. 2014;4(6):837-40.
6. Dharmage SC, Perret JL, Custovic A. Epidemiology of Asthma in Children and Adults. Front Pediatr. 2019;7:246.
7. Fazlollahi MR, Najmi M, Fallahnezhad M, Sabetkish N, Kazemnejad A, Bidad K, et al. The prevalence of asthma in Iranian adults: The first national survey and the most recent updates. Clin Respir J. 2018;12(5):1872-81.
8. Weiss ST, Raby BA, Rogers A. Asthma genetics and genomics 2009. Curr Opin Genet Dev. 2009;19(3):279-82.
9. Lee YC, Cheon KT, Lee HB, Kim W, Rhee YK, Kim DS. Gene polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in patients with asthma. Allergy. 2000;55(10):959-63.
10. Shao Z, Jin H, Sun H, Dong C, Xu B, Zhan L. Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to pediatric asthma: A meta-analysis. J Renin Angiotensin Aldosterone Syst. 2020;21(2):1470320320923475.
11. Kuba K, Imai Y, Penninger JM. Angiotensin-converting enzyme 2 in lung diseases. Curr Opinion Pharmacol. 2006;6(3):271-6.
12. Kaur P, Muthuraman A, Kaur M. The implications of angiotensin-converting enzymes and their modulators in neurodegenerative disorders: current and future perspectives. ACS Chem Neurosci. 2015;6(4):508-21.
13. Karamyan VT. Between two storms, vasoactive peptides or bradykinin underlie severity of COVID-19? Physiol Rep. 2021;9(5):e14796.
14. Benigni A, Cassis P, Remuzzi G. Angiotensin II revisited: new roles in inflammation, immunology and aging. EMBO Mol Med. 2010;2(7):247-57.
15. Verma K, Pant M, Paliwal S, Dwivedi J, Sharma S. An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update. Front Pharmacol. 2021;12(2175).
16. Sayed-Tabatabaei FA, Oostra BA, Isaacs A, Duijn CMv, Witteman JCM. ACEPolymorphisms.Circ Res. 2006;98(9):1123-33.
17. Han SY, Kwon YJ, Jo SK, Shin JH, Cha DR, Cho WY, et al. ACE gene polymorphism and renal responsiveness to ACE inhibitors in IgA nephropathy patients. Korean J Intern Med. 2000;15(1):13-8.
18. Dorudinia A, Shamaei M, Karimi S, Javadi A, Mohammadi Ziazi L, Pourabdollah M. Evaluation of in-house polymerase chain reaction assay sensitivity, can it be utilized in limited-resources settings? Med J Islam Repub Iran. 2014;28:126.
19. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990;86(4):1343-6.
20. Xu G, Fan G, Sun Y, Yu L, Wu S, Niu W. Association of angiotensin-converting enzyme gene I/D polymorphism with chronic obstructive pulmonary disease: a meta-analysis. J Renin Angiotensin Aldosterone Syst. 2018;19(2):1470320318770546.
21. Ding QL, Sun SF, Cao C, Deng ZC. Association between angiotensin-converting enzyme I/D polymorphism and asthma risk: a meta-analysis involving 11,897 subjects. J Asthma. 2012;49(6):557-62.
22. Zhang YG, Li XB, Zhang J, Huang J, He C, Tian C, et al. The I/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis. Allergy. 2011;66(2):197-205.
23. Chagani T, Paré PD, Zhu S, Weir TD, Bai TR, Behbehani NA, et al. Prevalence of tumor necrosis factor-alpha and angiotensin converting enzyme polymorphisms in mild/moderate and fatal/near-fatal asthma. Am J Respir Crit Care Med. 1999;160(1):278-82.
24. El-Shafei MS, Farres MN, Shahin RY. Evaluation of angiotensin converting enzyme gene polymorphism and susceptibility to bronchial asthma among Egyptians. Allergol Immunopathol (Madr). 2012;40(5):275-80.
25. Eryüksel E, Ceyhan BB, Bircan R, Avşar M, Cirakoğlu B. Angiotensin converting enzyme gene polymorphism in Turkish asthmatic patients. J Asthma. 2009;46(4):335-8.
26. Tomita H, Sato S, Matsuda R, Ogisu N, Mori T, Niimi T, et al. Genetic polymorphism of the angiotensin-converting enzyme (ACE) in asthmatic patients. Resp Med. 1998;92(12):1305-10.
27. Urhan M, Degirmenci I, Harmanci E, Gunes HV, Metintas M, Basaran A. High frequency of DD polymorphism of the angiotensin-converting enzyme gene in Turkish asthmatic patients. Allergy Asthma Proc. 2004;25(4):243-7.
28. Nakahama H, Obata K, Nakajima T, Nakamura H, Kitada O, Sugita M, et al. Renin-angiotensin system component gene polymorphism in Japanese bronchial asthma patients. J Asthma. 1999;36(2):187-93.
29. Cortez M, Matos A, Ferreira J, Lopes L, Gil A, Bicho M. ACE polymorphism in asthmatic patients. Clin Trans Allergy. 2013;3(1):P14.
30. Gao J, Lin Y, Xiao Y, Xu K, Xu W, Zhu Y, et al. Polymorphism of angiotensin-converting enzyme gene and genetic susceptibility to asthma with familial aggregation. Chin Med Sci J. 2000;15(1):24-8.
31. Eleni S, Dimitrios K, Vaya P, Areti M, Norma V, Magdalini G. Angiotensin-I converting enzyme gene and I/D polymorphism distribution in the Greek population and a comparison with other European populations. J Genet. 2008;87(1):91-3.
| Files | ||
| Issue | Vol 21 No 2 (2022) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijaai.v21i2.9218 | |
| Keywords | ||
| Asthma Genotype Single nucleotide polymorphism | ||
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How to Cite
1.
Moini A, Khirehgesh MR, Sarkhosh A, Godarzi A, Vaisi-Raygani A, Kiani A. Association of Angiotensin-converting Enzyme Gene Polymorphism with Susceptibility to Asthma Disease in Western Iran. Iran J Allergy Asthma Immunol. 2022;21(2):104-111.
