Quercetin as a Potential Anti-Allergic Drug: Which Perspectives?
Abstract
Flavonoids polyphenolic compounds that exert many anti-inflammatory and anti-microbial effects, and exhibit an anti-allergic action. Quercetin is a flavonoids that recently has raised many issues and shown evidence about its action as a potential drug to allergy. A Chinese herbal formula, known as Food Allergy Herbal Formula (FAHF) has been related with blocking of anaphylaxis to peanuts (PNA) in mouse models. Quercetin appears to possess the same potential of FAHF as a safe anti-allergic substance but it opens only a wide perspective, at the moment, due to several complex issues that hamper the possibility to use natural medicine and phytochemicals as true drugs.
1.Shishehbor F, Behroo L, Ghafouriyan Broujerdnia M, Namjoyan F, Latifi SM. Quercetin effectively quells peanut-induced anaphylactic reactions in the peanut sensitized rats. Iran J Allergy Asthma Immunol 2010;9(1):27-34.
2. Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets 2010; 9(4):263-85.
3. Burks W, Kulis M, Pons L. Food allergies and hypersensitivity: a review of pharmacotherapy and therapeutic strategies. Expert Opin Pharmacother 2008;9(7):1145-52.
4. Li XM. Beyond allergen avoidance: update on developing therapies for peanut allergy. Curr Opin Allergy Clin Immunol 2005; 5(3):287-92.
5. Song Y, Qu C, Srivastava K, Yang N, Busse P, Zhao W, et al. Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils. J Allergy Clin Immunol 2010;126(6):1208-17.
6. Chirumbolo S, Marzotto M, Conforti A, Vella A, Ortolani R, Bellavite P. Bimodal action of the flavonoid quercetin on basophil function: an investigation of the putative biochemical targets. Clin Mol Allergy 2010; 8:13-24.
7. Srivastava KD, Qu C, Zhang T, Goldfarb J, Sampson HA, Li XM. Food Allergy Herbal Formula-2 silences peanut- induced anaphylaxis for a prolonged posttreatment period via IFN-gamma-producing CD8+ T cells. J Allergy Clin Immunol 2009; 123(2):443-51.
8. Park HJ, Lee CM, Jung ID, Lee JS, Jeong YI, Chang JH, et al. Quercetin regulates Th1/Th2 balance in a murine model of asthma. Int Immunopharmacol 2009; 9(3):261-7.
9. Ozdemir C, Akdis M, Akdis CA. T-cell response to allergens. Chem Immunol Allergy 2010; 95:22-44.
10. Rogerio AP, Dora CL, Andrade EL, Chaves JS, Silva LF,Lemos-Senna E, et al. Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Pharmacol Res 2010;61(4):288-97.
| Files | ||
| Issue | Vol 10, No 2 (2011) | |
| Section | Articles | |
| Keywords | ||
| Flavonoids Natural Medicine Peanut Allergy Polyphenols Quercetin | ||
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