Brief Communication
 

Production of SARS-CoV-2 Antibodies and Emergence of the Clinical Symptoms of COVID-19

SARS-CoV-2 Antibodies and Clinical Symptoms Emergence

Abstract

Coronavirus disease 2019 (COVID-19) is a worldwide public health problem that has attracted much attention due to its clinical findings. Measurement of IgG and IgM antibodies is of great importance for researchers and it will help to develop a new diagnostic and therapeutic method in clinical care.
In this cross-sectional study, we aim to measure the IgG and IgM antibody levels in 401 suspected COVID-19 volunteers. We also measure the time duration for the appearance of IgG and IgM antibodies from the onset of symptoms to sampling time.
Of 401 participants enrolled in the study, 255 (63.59%) were healthy, 79 (19.70%) were a carrier, 59 (14.71%) were cured and 8 (1.99%) were borderline. Of 142 subjects diagnosed with COVID-19, 41 (28.87%) presented with gastrointestinal (GI) symptoms, 83 (58.45%) had no GI symptoms, and 18 (12.68%) were asymptomatic.
According to our findings, the measurement of IgG and IgM antibodies will provide the tool for the diagnosis of COVID-19 and significantly boost research into novel diagnostic and therapeutic approaches.

1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382:727-733.
2. Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed. 2020;91(1):157-60.
3. Hormati A, Shahhamzeh A, Aminnejad R, Afifian M, Ahmadpour S. Gastrointestinal Presentation in a Patient with COVID-19 Without Respiratory Tract Symptoms: A Case Report From Qom, Iran. Jundishapur J Microbiol. 2020;13(5):e102844.
4. Hormati A, Ghadir MR, Saeidi M, Aminnejad R, Khodadust F, Afifian M, et al. Dysentery as a rare GI symptom found in COVID-19 patients. Gastroenterol Hepatol. 2021; 44(1): 31.
5. Leung JM, Sin DD. Smoking, ACE-2 and COVID-19: ongoing controversies. Eur Respir J. 2020;56(1).
6. Zeng H, Xu C, Fan J, Tang Y, Deng Q, Zhang W, et al. Antibodies in infants born to mothers with COVID-19 pneumonia. Jama. 2020;323(18):1848-9.
7. Yongchen Z, Shen H, Wang X, Shi X, Li Y, Yan J, et al. Different longitudinal patterns of nucleic acid and serology testing results based on disease severity of COVID-19 patients. Emerg Microbes Infect. 2020;9(1):833-6.
8. Xie J, Ding C, Li J, Wang Y, Guo H, Lu Z, et al. Characteristics of patients with coronavirus disease (COVID‐19) confirmed using an IgM‐IgG antibody test. J Med Virol. 2020;92(10):2004-2010.
9. Venkat Kumar G, Jeyanthi V, Ramakrishnan S. A short review on antibody therapy for COVID-19. New Microbes New Infect. 2020;35:100682.
10. Sayed A, Challa KT, Arja S. Epidemiological Differences of COVID-19 Over the World. Cureus. 2020;12(9):e10316.
11. Hormati A, Ghadir MR, Zamani F, Khodadadi J, Khodadust F, Afifian M, et al. Are there any association between COVID-19 severity and immunosuppressive therapy?. Immunol Lett. 2020;224, 12–13.
12. Hormati A, Ghadir MR, Zamani F, Khodadadi J, Afifian M, Ahmadpour S. Preventive strategies used by GI physicians during the COVID-19 pandemic. New Microbes New Infect. 2020;35:100676.
13. Hormati A, Ghadir MR, Foroghi Ghomi SY, Afifian M , Khodadust F, Ahmadpour S. Can Increasing the Number of Close Contact Lead to More Mortality in COVID-19 Infected Patients? Iran J Public Health. 2020;49:117-118.
14. Zhong L, Chuan J, Gong B, Shuai P, Zhou Y, Zhang Y, et al. Detection of serum IgM and IgG for COVID-19 diagnosis. Sci China Life Sci. 2020;63(5):777-80.
15. Ye M, Fu D, Ren Y, Wang F, Wang D, Zhang F, et al. Treatment with convalescent plasma for COVID-19 patients in Wuhan, China. J Med Virol. 2020;92(10):1890-1901.
Files
IssueVol 20 No 2 (2021) QRcode
SectionBrief Communication
DOI https://doi.org/10.18502/ijaai.v20i2.6057
Keywords
Antibodies COVID-19 Diagnosis Polymerase chain reaction

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Hormati A, Poustchi H, Ghadir MR, Jafari S, Jafari N, Ashtari A, Ahmadpour S. Production of SARS-CoV-2 Antibodies and Emergence of the Clinical Symptoms of COVID-19. Iran J Allergy Asthma Immunol. 2021;20(2):244-248.