Brief Communication

Evaluation of NLRP3 and IL-18 Levels after Periodontal Therapy

NLRP3 and IL-18 Levels after Periodontal Therapy


The progression of periodontitis depends on interactions between the periodontal pathogens and the host immune cytokines, including interleukin (IL)-1β and IL-18. Production of IL-1β is regulated by NOD-like receptors family pyrin domain containing 3 (NLRP3). This study aimed to evaluate the effect of periodontal treatment on the concentrations of IL-18 and NLRP3 in patients with chronic periodontitis.
In this experimental study, 18 patients with chronic periodontitis and a mean age of 46.2±8.95 years, were included. The gingival crevicular fluid (GCF) was collected at the beginning of the study, 4 weeks after non-surgical (phase I), and 4 weeks after surgical periodontal treatment. The levels of NLRP3 and IL-18 were measured; using an enzyme-linked immunosorbent assay. Pearson correlation test was used to analyze the concentration of NLRP3 and IL-18 before and after the treatments with CAL and PD.
There was a significant association between the level of NLRP3 and the mean values of PD and CAL before treatment. After each treatment phase, a significant decrease was observed in the NLRP3 level. There was no significant relationship between IL-18 and clinical parameters before and after periodontal treatments.
Given the possible association between the level of NLRP3 and clinical parameters, we suggest it as a possible indicator of inflammation in chronic periodontitis and an index for evaluating the treatment outcome.

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IssueVol 20 No 6 (2021) QRcode
SectionBrief Communication
Chronic periodontitis Interleukin-18 NLRP3 protein

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How to Cite
Shahbeik S, Taleghani F, Sattari M, Mahvash Mohammadi M, Moravej M. Evaluation of NLRP3 and IL-18 Levels after Periodontal Therapy. Iran J Allergy Asthma Immunol. 2021;20(6):764-770.