Association between Gene Polymorphisms of T Cell Immunoglobulin Domain and Mucin Domain-3 and Risk of Asthma: A Systematic Review and Meta-analysis
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Abstract
Previous studies have reported that T cell immunoglobulin domain and mucin domain-3 (TIM-3) 574T>G and 1516G>T are associated with the risk of asthma. However, the results are inconsistent due to the small sample size and varied age in studies. We performed this meta-analysis to systematically evaluated the effect of TIM-3 574T>G and 1516G>T genetic polymorphisms on asthma.
Eligible articles that reported an association between TIM-3 574T>G and 1516G>T genetic polymorphisms and asthma were searched in PubMed, Medline, EMBASE, Google Scholar, and China National Knowledge Infrastructure up to April 2020. Random or fixed-effects models were used to calculate the summary of odds ratios (ORs) and 95% confidence intervals (CIs) to detect any potential associations between TIM-3 genetic polymorphisms and asthma. Subgroup and sensitivity analyses were performed to assess the potential sources of heterogeneity and the robustness of the pooled estimation. Publication bias was analyzed using the Egger test.
A total of 11 case-control studies including 2077 asthma patients and 2122 control subjects were finally analyzed (published data form 2004-2018). The pooled results indicated that TIM-3 574T>G genetic polymorphisms were significantly associated with an increased risk of asthma under the dominant model (GG vs. GT +TT: ORs=2.26, 95% CI 1.09-4.69) and allele model (G vs T: ORs=2.60, 95% CI 1.20-5.64). However, no significant associations between TIM-3 1516G>T genetic polymorphisms with asthma in any model was found. No evidence of publication bias was observed.
Our study indicates that TIM-3 574T>G genetic polymorphisms were associated with increased risk of asthma and the TIM-3 1516G>T genetic polymorphisms may not be correlated with asthma.
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2. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald JM, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008;31(1):143-78.
3. Ober C, Yao TC. The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev. 2011;242(1):10-30.
4. Pawankar R, Canonica GW, Holgate ST, Lockey RF. Allergic diseases and asthma: a major global health concern. Curr Opin Allergy Clin Immunol. 2012;12(1):39-41.
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6. Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 2002;415(6871):536-41.
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8. Sabatos CA, Chakravarti S, Cha E, Schubart A, Sanchez-Fueyo A, Zheng XX, et al. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol. 2003;4(11):1102-10.
9. Su EW, Lin JY, Kane LP. TIM-1 and TIM-3 proteins in immune regulation. Cytokine. 2008;44(1):9-13.
10. Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, et al. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009;39(9):2492-501.
11. Leavy O. TIM3: dual role in immunity. Nat Rev Immunol. 2008;8:4.
12. Song YW, Im CH, Park JH, Lee YJ, Lee EY, Lee EB, et al. T-cell immunoglobulin and mucin domain 3 genetic polymorphisms are associated with rheumatoid arthritis independent of a shared epitope status. Hum Immunol. 2011;72(8):652-5.
13. Zhang R, Li H, Bai L, Duan J. Association between T-Cell Immunoglobulin and Mucin Domain 3 (TIM-3) Genetic Polymorphisms and Susceptibility to Autoimmune Diseases. Immunol Invest. 2019;48(6):563-76.
14. Zhang Y, Cai P, Liang T, Wang L, Hu L. TIM-3 is a potential prognostic marker for patients with solid tumors: A systematic review and meta-analysis. Oncotarget. 2017;8(19):31705-13.
15. Fang H, Yuan C, Gu X, Chen Q, Huang D, Li H, et al. Association between TIM-3 polymorphisms and cancer risk: a meta-analysis. Ann Transl Med. 2019;7(20):550.
16. Chae SC, Park YR, Lee YC, Lee JH, Chung HT. The association of TIM-3 gene polymorphism with atopic disease in Korean population. Hum Immunol. 2004;65(12):1427-31.
17. Chae SC, Song JH, Pounsambath P, Yuan HY, Lee JH, Kim JJ, et al. Molecular variations in Th1-specific cell surface gene Tim-3. Exp Mol Med. 2004;36(3):274-8.
18. Zhang CC, Wu JM, Cui TP, Wang P, Pan SX. Study on relationship between polymorphism sites of TIM-3 and allergic asthma in a population of adult Hans from Hubei province of China.Chin J Med Genetics. 2006;23(1):74-7.
19. Wu Liqiang, Chen Jianping, He Nianhai, Gui Qin, Yan Ling, Chen Sheng. Relationship between TIM-3 gene polymorphism and cough variant asthma in children. J Third Mil Med Univ. 2012;34(22):2302-5.
20. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.PLoS Med. 2009;6(7):e1000100.
21. Medvedeva EA, Berezin, II, Surkova EA, Yaranov DM, Shchukin YV. Galectin-3 in patients with chronic heart failure: association with oxidative stress, inflammation, renal dysfunction and prognosis. Minerva Cardioangiol. 2016;64(6):595-602.
22. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539-58.
23. Seagroatt V, Stratton I. Bias in meta-analysis detected by a simple, graphical test. Test had 10% false positive rate. BMJ (Clinical research ed). 1998;316(7129):470; author reply -1.
24. Wu Xuelan, Cui Tianbin, Wu Jianmin. Relationship between Tim-3 promoter region -574 polymorphism and allergic asthma. J Microcirc Journal of Microcirculation. 2006(04):50-2.
25. Hu Lihua, Cui Tianbin, Zhang Cai Cheng, Wang Lin. Study of TIM-3 promoter region polymorphism in Han children with allergic asthma in Hubei region. Chin J Lab Med. 2006(02):125-7.
26. Li Jisheng, Liu Miracle, Wang Pin, Li Huai Chen, Wei Chun Hua, Guo Chen Hong, et al. Correlation between two single nucleotide polymorphisms in the promoter region of TIM-3 gene and bronchial asthma in Han Chinese population in Shandong, China.J Shandong Univ (Medical Edition). 2006(11):1159-63.
27. Sadri M, Ganjalikhani-Hakemi M, Akbari P, Salehi R, Rastaghi S, Ghasemi R, et al. Association between +4259 T>G and -574 G>T Polymorphisms of TIM-3 with Asthma in an Iranian Population. Iran J Allergy Asthma Immunol. 2017;16(4):321-8.
28. Jin Xiuhua, Li Yandong. The relationship between TIM-3 promoter region -1516G/T(Rs10053538) and exon region-882C/T(Rs4704853),-574T/G(Rs1051746)polymorphisms and asthma in Mongolian children. J Mod Lab Med. 2018;33(04):73-5.
29. Chen Zhizhong, Li Yirong, Chen Fenghua, Wang Lin, Li Hong, Hu Lihua. Correlation between TIM-3 gene polymorphism and allergic asthma in Chinese Han Chinese population. Chinese Chin J Lab Med. 2007;30(11):1266-8.
30. Hu Lihua. Correlation between T-lymphocyte immunoglobulin mucin-3 haplotype and allergic bronchial asthma in a Han population in Hubei. Chin J Tuberculosis Respir Dis. 2008;31(3).
31. Reséndiz-Hernández JM, Falfán-Valencia R. Genetic polymorphisms and their involvement in the regulation of the inflammatory response in asthma and COPD. Adv Clin Exp Med 2018;27(1):125-33.
32. Li H, Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, Estela Del Rio-Navarro B, Kistner EO, et al. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. J Allergy Clin Immunol. 2006;117(1):119-26.
33. Li Z, Ju Z, Frieri M. The T-cell immunoglobulin and mucin domain (Tim) gene family in asthma, allergy, and autoimmunity. Allergy Asthma Proc. 2013;34(1):e21-6.
34. Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK. The TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med. 2005;11(8):362-9.
35. Wang G, Wang F, Gibson PG, Guo M, Zhang WJ, Gao P, et al. Severe and uncontrolled asthma in China: a cross-sectional survey from the Australasian Severe Asthma Network. J Thorac Dis. 2017;9(5):1333-44.
2. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald JM, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008;31(1):143-78.
3. Ober C, Yao TC. The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev. 2011;242(1):10-30.
4. Pawankar R, Canonica GW, Holgate ST, Lockey RF. Allergic diseases and asthma: a major global health concern. Curr Opin Allergy Clin Immunol. 2012;12(1):39-41.
5. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol. 2008;8(3):169-82.
6. Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 2002;415(6871):536-41.
7. Sanchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, et al. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol. 2003;4(11):1093-101.
8. Sabatos CA, Chakravarti S, Cha E, Schubart A, Sanchez-Fueyo A, Zheng XX, et al. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol. 2003;4(11):1102-10.
9. Su EW, Lin JY, Kane LP. TIM-1 and TIM-3 proteins in immune regulation. Cytokine. 2008;44(1):9-13.
10. Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, et al. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009;39(9):2492-501.
11. Leavy O. TIM3: dual role in immunity. Nat Rev Immunol. 2008;8:4.
12. Song YW, Im CH, Park JH, Lee YJ, Lee EY, Lee EB, et al. T-cell immunoglobulin and mucin domain 3 genetic polymorphisms are associated with rheumatoid arthritis independent of a shared epitope status. Hum Immunol. 2011;72(8):652-5.
13. Zhang R, Li H, Bai L, Duan J. Association between T-Cell Immunoglobulin and Mucin Domain 3 (TIM-3) Genetic Polymorphisms and Susceptibility to Autoimmune Diseases. Immunol Invest. 2019;48(6):563-76.
14. Zhang Y, Cai P, Liang T, Wang L, Hu L. TIM-3 is a potential prognostic marker for patients with solid tumors: A systematic review and meta-analysis. Oncotarget. 2017;8(19):31705-13.
15. Fang H, Yuan C, Gu X, Chen Q, Huang D, Li H, et al. Association between TIM-3 polymorphisms and cancer risk: a meta-analysis. Ann Transl Med. 2019;7(20):550.
16. Chae SC, Park YR, Lee YC, Lee JH, Chung HT. The association of TIM-3 gene polymorphism with atopic disease in Korean population. Hum Immunol. 2004;65(12):1427-31.
17. Chae SC, Song JH, Pounsambath P, Yuan HY, Lee JH, Kim JJ, et al. Molecular variations in Th1-specific cell surface gene Tim-3. Exp Mol Med. 2004;36(3):274-8.
18. Zhang CC, Wu JM, Cui TP, Wang P, Pan SX. Study on relationship between polymorphism sites of TIM-3 and allergic asthma in a population of adult Hans from Hubei province of China.Chin J Med Genetics. 2006;23(1):74-7.
19. Wu Liqiang, Chen Jianping, He Nianhai, Gui Qin, Yan Ling, Chen Sheng. Relationship between TIM-3 gene polymorphism and cough variant asthma in children. J Third Mil Med Univ. 2012;34(22):2302-5.
20. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.PLoS Med. 2009;6(7):e1000100.
21. Medvedeva EA, Berezin, II, Surkova EA, Yaranov DM, Shchukin YV. Galectin-3 in patients with chronic heart failure: association with oxidative stress, inflammation, renal dysfunction and prognosis. Minerva Cardioangiol. 2016;64(6):595-602.
22. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539-58.
23. Seagroatt V, Stratton I. Bias in meta-analysis detected by a simple, graphical test. Test had 10% false positive rate. BMJ (Clinical research ed). 1998;316(7129):470; author reply -1.
24. Wu Xuelan, Cui Tianbin, Wu Jianmin. Relationship between Tim-3 promoter region -574 polymorphism and allergic asthma. J Microcirc Journal of Microcirculation. 2006(04):50-2.
25. Hu Lihua, Cui Tianbin, Zhang Cai Cheng, Wang Lin. Study of TIM-3 promoter region polymorphism in Han children with allergic asthma in Hubei region. Chin J Lab Med. 2006(02):125-7.
26. Li Jisheng, Liu Miracle, Wang Pin, Li Huai Chen, Wei Chun Hua, Guo Chen Hong, et al. Correlation between two single nucleotide polymorphisms in the promoter region of TIM-3 gene and bronchial asthma in Han Chinese population in Shandong, China.J Shandong Univ (Medical Edition). 2006(11):1159-63.
27. Sadri M, Ganjalikhani-Hakemi M, Akbari P, Salehi R, Rastaghi S, Ghasemi R, et al. Association between +4259 T>G and -574 G>T Polymorphisms of TIM-3 with Asthma in an Iranian Population. Iran J Allergy Asthma Immunol. 2017;16(4):321-8.
28. Jin Xiuhua, Li Yandong. The relationship between TIM-3 promoter region -1516G/T(Rs10053538) and exon region-882C/T(Rs4704853),-574T/G(Rs1051746)polymorphisms and asthma in Mongolian children. J Mod Lab Med. 2018;33(04):73-5.
29. Chen Zhizhong, Li Yirong, Chen Fenghua, Wang Lin, Li Hong, Hu Lihua. Correlation between TIM-3 gene polymorphism and allergic asthma in Chinese Han Chinese population. Chinese Chin J Lab Med. 2007;30(11):1266-8.
30. Hu Lihua. Correlation between T-lymphocyte immunoglobulin mucin-3 haplotype and allergic bronchial asthma in a Han population in Hubei. Chin J Tuberculosis Respir Dis. 2008;31(3).
31. Reséndiz-Hernández JM, Falfán-Valencia R. Genetic polymorphisms and their involvement in the regulation of the inflammatory response in asthma and COPD. Adv Clin Exp Med 2018;27(1):125-33.
32. Li H, Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, Estela Del Rio-Navarro B, Kistner EO, et al. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. J Allergy Clin Immunol. 2006;117(1):119-26.
33. Li Z, Ju Z, Frieri M. The T-cell immunoglobulin and mucin domain (Tim) gene family in asthma, allergy, and autoimmunity. Allergy Asthma Proc. 2013;34(1):e21-6.
34. Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK. The TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med. 2005;11(8):362-9.
35. Wang G, Wang F, Gibson PG, Guo M, Zhang WJ, Gao P, et al. Severe and uncontrolled asthma in China: a cross-sectional survey from the Australasian Severe Asthma Network. J Thorac Dis. 2017;9(5):1333-44.
| Files | ||
| Issue | Vol 20 No 1 (2021) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijaai.v20i1.5407 | |
| Keywords | ||
| Asthma Meta-analysis Polymorphism | ||
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How to Cite
1.
Wei W, Huang J, Ma Y, Hao C, Zhang S. Association between Gene Polymorphisms of T Cell Immunoglobulin Domain and Mucin Domain-3 and Risk of Asthma: A Systematic Review and Meta-analysis. Iran J Allergy Asthma Immunol. 2021;20(1):1-10.
