Interleukin-18 Polymorphisms Deficiency Association with Asthma Risk: An Update Meta-analysis
Abstract
Growing evidence indicated conflicting results that Interleukin-18 (IL-18) promoter polymorphisms rs1946518 (A-607C), rs187238 (G-137C) and rs549908 (A-105C) were associated with asthma risk. The aim of this study is to comprehensively evaluate the IL-18 polymorphisms and asthma by a systematic review and meta-analysis. A total of 12 studies testing the association between these polymorphisms and asthma were examined (8 studies for A-607C, 8 studies for G-137C, and 4 studies for A-105C) in the update meta-analysis, up to Dec 30, 2017. Summary odds ratios (ORs) and 95% confidence intervals (CI) were used to estimate the strength of association between each polymorphism and asthma using fixed- and random-effects models when appropriate. Heterogeneity and publication bias were evaluated. The meta-analysis results indicated that any allele frequencies of the IL-18 polymorphisms (A-607C, G-137C and A-105C) was not associated with asthma risk (p>0.05). And no statistically significant association was observed between genotype frequencies of these polymorphisms and asthma under different genetic models (p>0.05). Subgroup analysis results were similar to the main analysis by ethnicity, sample size, genotyping methods, matching criteria and quality score. There was no evidence of publication bias. The present meta-analysis suggests that IL-18 polymorphisms (A-607C, G-137C and A-105C) were unlikely to be associated with asthma risk.
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4. Tattersfield AE, Knox AJ, Britton JR , Hall IP. Asthma. Lancet 2002; 360(9342):1313-22.
5. Huang XZ, Zhuang JH, Ren YG, Zhou LJ, Zhou Q. Association of interleukin-6 and interleukin-18 gene polymorphism with rheumatoid arthritis in Guangdong Han population. Nan Fang Yi Ke Da Xue Xue Bao 2007; 27(11):1661-4.
6. Pawlik A, Kaminski M, Kuśnierczyk P, Kurzawski M, Dziedziejko V, Adamska M, et al. Interleukin-18 promoter polymorphism in patients with atopic asthma. Tissue Antigens 2007; 70(4):314-8.
7. Nakamura K, Okamura H, Wada M, Nagata K, Tamura T. Endotoxin- induced serum factor that stimulates gamma interferon production. Infect Immun 1989; 57(2):590-5.
8. Chang JT, Segal BM, Nakanishi K, Okamura H, Shevach EM. The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit. Eur J Immunol 2000; 30(4):1113-9.
9. Blumenthal MN, Langefeld CD, Beaty TH, Bleecker ER, Ober C, Lester L, et al. A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma. Hum Genet 2003; 114(2):157–64.
10. Lachheb J, Chelbi H, Ammar J, Hamzaoui K, Hamzaoui A. Promoter polymorphism of the IL-18 gene is associated with atopic asthma in Tunisian children. Int J Immunogenet 2008; 35(1):63-68.
11. Imboden M, Nicod L, Nieters A, Glaus E, Matyas G, Bircher AJ, et al.The common G-allele of interleukin-18 single-nucleotide polymorphism is a genetic risk factor for atopic asthma. The SAPALDIA Cohort Study. Clin Exp Allergy 2006; 36(2):211-8.
12. Birbian N, Singh J, Jindal SK. Protective role of IL-18 -137G/C polymorphism in a North Indian population with asthma: a pilot study. Cytokine 2013; 61(1):188-93.
13. Wu SQ, Liang W, Wang GL, Li LY, Wang DL, Chen C. Polymorphisms of the IL-18 promoter and bronchial asthma. Mol Med Rep 2012; 6(6):1385-8.
14. Lee CC, Lin WY, Wan L, Tsai Y, Tsai CH, Huang CM, et al. Association of interleukin-18 gene polymorphism with asthma in Chinese patients. J Clin Lab Anal 2008; 22(1):39-44.
15. Shin HD, Kim LH, Park BL, Choi YH, Park HS, Hong SJ, et al. Association of interleukin 18 (IL18) polymorphisms with specific IgE levels to mite allergens among asthmatic patients. Allergy 2005; 60(7):900-6.
16. Heinzmann A, Gerhold K, Ganter K, Kurz T, Schuchmann L, Keitzer R, et al. Association study of polymorphisms within interleukin-18 in juvenile idiopathic arthritis and bronchial asthma. Allergy 2004 59(8):845-9.
17. Shaaban HH, Mohy AM, Abdel-Razek AR, Wahab AA. Interleukin-18 -607C/A gene polymorphism in Egyptian asthmatic children. Mol Diagn Ther 2014; 18(4):427-34.
18. Yi Jingping, CHEN Xiaowen, LI Jianchun,Deng qiong, Association study of interleukin-18 gene polymorphisms and asthma in Jiangxi province. Experimental and Laboratory Medicine 2013, 31(4):309-310.
19. Ying Ma, Bo Zhang, Ren-Kuan Tang, Yun Liu, Guo-Guang Peng. Interleukin-18 promoter polymorphism and asthma risk: a meta-analysis. Mol Biol Rep 2012; 39(2):1371-6.
20. Harada M, Obara K, Hirota T, Yoshimoto T, Hitomi Y, Sakashita Met al. A functional polymorphism in IL-18 is associated with severity of bronchial asthma. Am J Respir Crit Care Med 2009; 180(11):1048-55.
21. Higa S, Hirano T, Mayumi M, Hiraoka M, Ohshima Y, Nambu M, et al. Association between interleukin-18 gene polymorphism 105A/C and asthma. Clin Exp Allergy 2003; 33(8):1097-1102.
22. Aker S, Bantis C, Reis P, Kuhr N, Schwandt C, Grabensee B, et al. Influence of interleukin-6 G-174C gene polymorphism on coronary artery disease, cardiovascular complications and mortality in dialysis patients. Nephrol Dial Transplant 2009; 24(9):2847-2851.
23. Ma Y, Tang RK, Yang X, Peng GG, Liu Y, Wang XM, et al. Lack of an association between interleukin-6 gene promoter polymorphisms (-174G/C, -572G/C) and ischemic heart disease and/or ischemic stroke: a meta-analysis. Hum Immunol 2011; 72(8):641-51.
24. Thakkinstian A, McEvoy M, Minelli C, Gibson P, Hancox B, Duffy D, et al. Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review. Am J Epidemiol 2005; 162(3):201-11.
25. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21(11):1539-58.
26. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003, 327(7414):557-60.
27. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22(4):719-48.
28. Dersimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177-86.
29. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315(7109):629-34.
30. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50(4):1088-101.
31. Tanaka H, Miyazaki N, Oashi K, Teramoto S, Shiratori M, Hashimoto M, et al. IL-18 might reflect disease activity in mild and moderate asthma exacerbation. J Allergy Clin Immunol 2001; 107(2):331-336.
32. El-Mezzein RE, Matsumoto T, Nomiyama H, Miike T. Increased secretion of IL-18 in vitro by peripheral blood mononuclear cells of patients with bronchial asthma and atopic dermatitis. Clin Exp Immunol 2001; 126(2):193-8.
2. Holgate ST, Davies DE, Powell RM, Howarth PH, Haitchi HM, Holloway JW. Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms. Eur Respir J 2007; 29(4):793-803.
3. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol .2008, 8:169-182.
4. Tattersfield AE, Knox AJ, Britton JR , Hall IP. Asthma. Lancet 2002; 360(9342):1313-22.
5. Huang XZ, Zhuang JH, Ren YG, Zhou LJ, Zhou Q. Association of interleukin-6 and interleukin-18 gene polymorphism with rheumatoid arthritis in Guangdong Han population. Nan Fang Yi Ke Da Xue Xue Bao 2007; 27(11):1661-4.
6. Pawlik A, Kaminski M, Kuśnierczyk P, Kurzawski M, Dziedziejko V, Adamska M, et al. Interleukin-18 promoter polymorphism in patients with atopic asthma. Tissue Antigens 2007; 70(4):314-8.
7. Nakamura K, Okamura H, Wada M, Nagata K, Tamura T. Endotoxin- induced serum factor that stimulates gamma interferon production. Infect Immun 1989; 57(2):590-5.
8. Chang JT, Segal BM, Nakanishi K, Okamura H, Shevach EM. The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit. Eur J Immunol 2000; 30(4):1113-9.
9. Blumenthal MN, Langefeld CD, Beaty TH, Bleecker ER, Ober C, Lester L, et al. A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma. Hum Genet 2003; 114(2):157–64.
10. Lachheb J, Chelbi H, Ammar J, Hamzaoui K, Hamzaoui A. Promoter polymorphism of the IL-18 gene is associated with atopic asthma in Tunisian children. Int J Immunogenet 2008; 35(1):63-68.
11. Imboden M, Nicod L, Nieters A, Glaus E, Matyas G, Bircher AJ, et al.The common G-allele of interleukin-18 single-nucleotide polymorphism is a genetic risk factor for atopic asthma. The SAPALDIA Cohort Study. Clin Exp Allergy 2006; 36(2):211-8.
12. Birbian N, Singh J, Jindal SK. Protective role of IL-18 -137G/C polymorphism in a North Indian population with asthma: a pilot study. Cytokine 2013; 61(1):188-93.
13. Wu SQ, Liang W, Wang GL, Li LY, Wang DL, Chen C. Polymorphisms of the IL-18 promoter and bronchial asthma. Mol Med Rep 2012; 6(6):1385-8.
14. Lee CC, Lin WY, Wan L, Tsai Y, Tsai CH, Huang CM, et al. Association of interleukin-18 gene polymorphism with asthma in Chinese patients. J Clin Lab Anal 2008; 22(1):39-44.
15. Shin HD, Kim LH, Park BL, Choi YH, Park HS, Hong SJ, et al. Association of interleukin 18 (IL18) polymorphisms with specific IgE levels to mite allergens among asthmatic patients. Allergy 2005; 60(7):900-6.
16. Heinzmann A, Gerhold K, Ganter K, Kurz T, Schuchmann L, Keitzer R, et al. Association study of polymorphisms within interleukin-18 in juvenile idiopathic arthritis and bronchial asthma. Allergy 2004 59(8):845-9.
17. Shaaban HH, Mohy AM, Abdel-Razek AR, Wahab AA. Interleukin-18 -607C/A gene polymorphism in Egyptian asthmatic children. Mol Diagn Ther 2014; 18(4):427-34.
18. Yi Jingping, CHEN Xiaowen, LI Jianchun,Deng qiong, Association study of interleukin-18 gene polymorphisms and asthma in Jiangxi province. Experimental and Laboratory Medicine 2013, 31(4):309-310.
19. Ying Ma, Bo Zhang, Ren-Kuan Tang, Yun Liu, Guo-Guang Peng. Interleukin-18 promoter polymorphism and asthma risk: a meta-analysis. Mol Biol Rep 2012; 39(2):1371-6.
20. Harada M, Obara K, Hirota T, Yoshimoto T, Hitomi Y, Sakashita Met al. A functional polymorphism in IL-18 is associated with severity of bronchial asthma. Am J Respir Crit Care Med 2009; 180(11):1048-55.
21. Higa S, Hirano T, Mayumi M, Hiraoka M, Ohshima Y, Nambu M, et al. Association between interleukin-18 gene polymorphism 105A/C and asthma. Clin Exp Allergy 2003; 33(8):1097-1102.
22. Aker S, Bantis C, Reis P, Kuhr N, Schwandt C, Grabensee B, et al. Influence of interleukin-6 G-174C gene polymorphism on coronary artery disease, cardiovascular complications and mortality in dialysis patients. Nephrol Dial Transplant 2009; 24(9):2847-2851.
23. Ma Y, Tang RK, Yang X, Peng GG, Liu Y, Wang XM, et al. Lack of an association between interleukin-6 gene promoter polymorphisms (-174G/C, -572G/C) and ischemic heart disease and/or ischemic stroke: a meta-analysis. Hum Immunol 2011; 72(8):641-51.
24. Thakkinstian A, McEvoy M, Minelli C, Gibson P, Hancox B, Duffy D, et al. Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review. Am J Epidemiol 2005; 162(3):201-11.
25. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21(11):1539-58.
26. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003, 327(7414):557-60.
27. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22(4):719-48.
28. Dersimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177-86.
29. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315(7109):629-34.
30. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50(4):1088-101.
31. Tanaka H, Miyazaki N, Oashi K, Teramoto S, Shiratori M, Hashimoto M, et al. IL-18 might reflect disease activity in mild and moderate asthma exacerbation. J Allergy Clin Immunol 2001; 107(2):331-336.
32. El-Mezzein RE, Matsumoto T, Nomiyama H, Miike T. Increased secretion of IL-18 in vitro by peripheral blood mononuclear cells of patients with bronchial asthma and atopic dermatitis. Clin Exp Immunol 2001; 126(2):193-8.
| Files | ||
| Issue | Vol 18, No 3 (2019) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijaai.v18i3.1118 | |
| PMID | 31522432 | |
| Keywords | ||
| Asthma Genetic susceptibility Interleukin-18 Meta-analysis Single nucleotide polymorphism | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Liu H, Feng Y, Zhang W, Deng X-D, Ma Y, Liu Y. Interleukin-18 Polymorphisms Deficiency Association with Asthma Risk: An Update Meta-analysis. Iran J Allergy Asthma Immunol. 2019;18(3):251-261.
