Iranian Journal of Allergy, Asthma and Immunology 2015. 14(1):1-11.

Association between FcεRIβ and IFN-γ Polymorphisms and Asthma in Asian Population: a Meta-Analysis.
Ying-Shui Yao, Jie Li, Yue-Long Jin, Lian-Ping He, Wei-Wei Chang, Yan Chen, Ling-Ling Ding, Wei Lu, Chao-Pin Li


Polymorphisms in the β subunit of the high affinity receptor for IgE (FcεRIβ) and interferon-γ (IFN-γ) genes may influence the risk of asthma. However, the results in Asian population are still debatable. We performed a meta-analysis to ascertain the association between the FcεRIβ E237G, FcεRIβ -109C/T, and IFN-γ 874T/A polymorphisms and asthma in an Asian population. Databases including PubMed, Chinese National Knowledge Infrastructure (CNKI), Weipu, and Wan Fang (Chinese) databases were searched to find the relevant studies. The effect summary odds ratio (OR) with 95% confidence interval (CI) was calculated. There was no significant difference in dominant model and allele model (EG + GG vs. EE: OR = 1.14, 95%CI = 0.94-1.40; G vs. E: OR = 1.13, 95%CI = 0.95-1.34) for FcεRIβ E237G, and no significant association was observed in the subgroup analysis by age and atopic status. A significantly decreased risk of asthma was observed in allelic model (C vs. T: OR=0.88, 95%CI=0.80-0.98) for FcεRIβ -109C/T, significant association was found in dominant model (AT+TT vs. AA: OR=0.56, 95% CI=0.33-0.97) for IFN-γ 874T/A. This meta-analysis suggested that FcεRIβ E237G is not an influencing factor for asthma in Asian population. FcεRIβ -109C/T and IFN-γ 874T/A polymorphisms may be influencing factors for asthma in the Asian population.


Asthma; High affinity receptor; IgE; Interferon-γ; Meta-Analysis; Polymorphism

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1.   Asthma         []
2.   Ober C, Yao TC. The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev 2011;242(1):10-30.
3. Fu JJ, Bainefs KJ, Wood LG, Gibson PG. Systemic inflammation is associated with differential gene expression  and  airway neutrophilia  in  asthma.  OMICS2013; 17(4):187-99.
4.   Chen J, Jiang X, Duan Y, Long J, Bartsch JW, Deng L.ADAM8    in    asthma.    Friend    or    foe    to    airway inflammation?   Am   J   Respir   Cell   Mol   Biol   2013;49(6):875-84.
5.   Song GG,  Lee  YH.  Pathway analysis  of genome-wide association   study   on   asthma.   Hum   Immunol   2013;74(2):256-60.
6.   Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG. Association of asthma with serum IgE levels and skin-test  reactivity  to  allergens.  N  Engl  J  Med  1989;320(5):271-7.
7.  Kaminuma O, Kitamura F, Miyatake S, Yamaoka K, Miyoshi  H,  Inokuma  S,  et  al.  T-box  21  transcription factor is responsible for distorted T(H)2 differentiation in human peripheral CD4+ T cells. J Allergy Clin Immunol 2009; 123(4):813-23.
8.   Kim Y, Lee S, Kim YS, Lawler S, Gho YS, Kim YK, et al. Regulation of Th1/Th2 cells in asthma development: a mathematical model. Math Biosci Eng 2013; 10(4):1095-133.
9.   Potaczek  DP,  Sanak  M,  Mastalerz  L,  Setkowicz  M, Kaczor  M,  Nizankowska  E,  et  al.  The  alpha-chain  of high-affinity receptor for IgE (FcepsilonRIalpha) gene polymorphisms  and  serum  IgE  levels.  Allergy  2006;61(10):1230-3.
10. Sandford AJ, Shirakawa T, Moffatt MF, Daniels SE, Ra C, Faux JA, et al. Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. Lancet 1993; 341(8841):332-4.
11. Trabetti E, Cusin V, Malerba G, Martinati LC, Casartelli A, Boner AL, et al. Association of the FcepsilonRIbeta gene with  bronchial hyper-responsiveness in  an  Italian population. J Med Genet 1998; 35(8):680-1.
12. Hizawa N, Maeda Y, Konno S, Fukui Y, Takahashi D, Nishimura M. Genetic polymorphisms at FCER1B and PAI-1 and asthma susceptibility. Clin Exp Allergy 2006;36(7):872-6.
13. Cui T, Wang L, Wu J, Xie J. The association analysis of FcepsilonRIbeta with allergic asthma in a Chinese population. Chin Med J (Engl) 2003; 116(12):1875-8.
14. Zhang X, Zhang W, Qiu D, Sandford A, Tan WC. The E237G polymorphism of the high-affinity IgE receptor beta chain  and  asthma.  Ann  Allergy Asthma  Immunol 2004; 93(5):499-503.
15. Kamali-Sarvestani    E,    Ghayomi    MA,    Nekoee    A.Association of TNF-alpha -308 G/A and IL-4 -589 C/T gene promoter polymorphisms with asthma susceptibility in the south of Iran. J Investig Allergol Clin Immunol 2007; 17(6):361-6.
16. Figueiredo  CA,  Rodrigues  LC,  Alcantara-Neves  NM, Cooper PJ, Amorim LD, Silva NB, et al. Does IFN- gamma  play a  role  on  the  pathogenesis  of  non-atopic asthma in Latin America children? Allergy Asthma Clin Immunol 2012; 8(1):18.
17. Hussein YM, Ahmad AS, Ibrahem MM, El Tarhouny SA, Shalaby SM, Elshal AS, et al: Interferon gamma gene polymorphism  as  a  biochemical  marker  in  Egyptian atopic patients. J Investig Allergol Clin Immunol 2009;19(4):292-8.
18. Palikhe NS, Kim SH, Cho BY, Ye YM, Hur GY, Park HS. Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma. Respir Med 2008, 102(8):1132-9.
19. Wang  JY,  Liou  YH,  Wu  YJ,  Hsiao  YH,  Wu  LS.  An association study of 13 SNPs from seven candidate genes with pediatric asthma and a preliminary study for genetic testing by multiple variants in Taiwanese population. J Clin Immunol 2009; 29(2):205-9.
20. Tang Y, Zeng Y, Li Y. Study on mutations of beta chain of high-affinity IgE receptor gene in people of Han nationality of southern China. Zhonghua Jie He He Hu Xi Za Zhi 2001; 24(3):142-4.
21. Li Z, Lu J, Li J, Sun X, Liao B. [Association between children asthma and the interferon gamma polymorphism gene]. Chinese Journal of Birth Health & Heredity 2006;14(9):22-3.
22. Ishizawa  M,  Shibasaki  M,  Yokouchi  Y,  Noguchi  E, Arinami  T,  Yamakawa-Kobayashi  K,  et  al.  No association between atopic asthma and a coding variant of Fc epsilon R1 beta in a Japanese population. J Hum Genet 1999; 44(5):308-11.
23. Chen HH, Wang JY, Jan RL, Liu YH, Liu LF. Reliability and validity of childhood asthma control test in a population of Chinese asthmatic children. Qual Life Res 2008; 17(4):585-93.
24. Iwanaga T, McEuen A, Walls AF, Clough JB, Keith TP, Rorke S, et al. Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E  levels  in  adult  atopic  dermatitis.  Clin  Exp  Allergy 2004; 34(7):1037-42.
25. Daneshmandi    S,    Pourfathollah    AA,    Pourpak    Z, Heidarnazhad H, Kalvanagh PA. Cytokine gene polymorphism and asthma susceptibility, progress and control level. Mol Biol Rep 2012; 39(2):1845-53.
26. Lee YH, Woo JH, Choi SJ, Ji JD, Song GG. Functional monocyte chemoattractant protein-1 promoter -2518 polymorphism and systemic lupus erythematosus: a meta- analysis. Mol Biol Rep 2010; 37(7):3421-6.
27. Wang J, Pan HF, Hu YT, Zhu Y, He Q. Polymorphism of IL-8  in  251  allele  and  gastric  cancer  susceptibility:  a meta-analysis. Dig Dis Sci 2010; 55(7):1818-23.
28. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21(11):1539-58.
29. MANTEL N, HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959, 22(4):719-48.
30. Yu  L,  Zhang  Y,  Chen  C,  Cui  HF,  Yan  XK.  [Meta-analysis  on   randomized   controlled   clinical   trials   of acupuncture  for  asthma].  Zhongguo  Zhen  Jiu  2010;30(9):787-92.
31. Begg C, Mazumdar M. Operating characteristics of a rank correlation  test  for  publication  bias.  Biometrics  1994;50(4):1088-101.
32. Song F, Gilbody S. Bias in meta-analysis detected by a simple, graphical test. Increase in studies of publication bias coincided with increasing use of meta-analysis. BMJ 1997; 316(7129):471.
33. Rohrbach M, Kraemer R, Liechti-Gallati S. Screening of the Fc epsilon RI-beta-gene in a Swiss population of asthmatic children: no association with E237G and identification of new sequence variations. Dis Markers 1998; 14(3):177-86.
34. Chen  H,  Chen  Y,  Hu  L.  [Study  on  the  FcepsilonRI- beta polymorphism and susceptibility of asthma in a Chinese  population].  Zhonghua  Yi  Xue  Za  Zhi  2000;80(9):664-7.
35. Cui TP, Wang L, Xie JG, Hu LH, Wu JM. [Study on the high-affinity IgE receptor beta gene polymorphism and its association with the susceptibility to allergic asthma in Han nationality of Hubei province]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003; 20(4):307-10.
36. Cui TP, Wang L, Xie JG, Hu LH, Wu JM. Association between    the    high-affinity    IgE    receptor    β    gene polymorphism and allergic asthma among adult in Hubei province. Chin J Pathophysiol 2003; 20(4):307-10.
37. Hizawa  N,  Yamaguchi  E,  Jinushi  E,  Kawakami  Y.  A common FCER1B gene promoter polymorphism influences   total   serum   IgE   levels   in   a   Japanese population. Am J Respir Crit Care Med 2000; 161(3 Pt1):906-9.
38. Huang H,  Wu  J: Association  of IFN-γ and  IL-4  gene polymorphisms with childhood bronchial asthmatic susceptibility and the levels of plasma IFN-γ, IL-4 and IgE. Chin J Pathophysiol 2010, 26:1769-75.
39. Hoffjan S, Ostrovnaja I, Nicolae D, Newman DL, Nicolae R,     Gangnon    R,    et    al.    Genetic    variation    in immunoregulatory pathways and atopic phenotypes in infancy. J Allergy Clin Immunol 2004, 113(3):511-8.
40. Dmitrieva-Zdorova  EV,  Voronko  OE,  Latysheva  EA, Storozhakov  GI,  Archakov  AI.  Analysis  of polymorphisms in T(H)2-associated genes in Russian patients with atopic bronchial asthma. J Investig Allergol Clin Immunol 2012; 22(2):126-32.
41. Green SL, Gaillard MC, Song E, Dewar JB, Halkas A.
Polymorphisms of the beta chain of the high-affinity immunoglobulin E receptor (Fcepsilon RI-beta) in South African black and white asthmatic and nonasthmatic individuals. Am J Respir Crit Care Med 1998; 158(5 Pt1):1487-92.
42. Pino-Yanes M, Corrales A, Cumplido J, Poza P, Sanchez- Machin  I,  Sanchez-Palacios  A,  et  al.  Assessing  the validity of asthma associations for eight candidate genes and   age   at   diagnosis   effects.   PLoS   One   2013;8(9):e73157.
43. Li Y, Wu B, Xiong H, Zhu C, Zhang L. Polymorphisms of STAT-6, STAT-4 and IFN-gamma genes and the risk of  asthma  in  Chinese  population.  Respir  Med  2007;101(9):1977-81.
44. Tu  X, Kuang J, Zou Y, Rao J: Research on relationship between the high affinity IgE receptor B chain gene polymorphism  and  the  total  serum  IgE  in  bronchial asthma patients. Chin J Tuberc Respir Dis 2004, 27:704-5.
45. Du Q, Li M, Xu G, Liu C, Liu  X, Yan Y: [Correlation between high affinity immunoglobulin E receptor gene and asthmatic children in Sichuan of China]. Med J West China 2006, 18(1):19-21.
46. Li M, Du Q, Li L, Song L, Li B. [Gene mutation of high affinity immunoglobulin E receptor beta-chain in children with asthma]. Zhongguo Dang Dai Er Ke Za Zhi 2006;8(6):453-6.
47. Undarmaa S, Mashimo Y, Hattori S, Shimojo N, Fujita K, Miyatake A, et al. Replication of genetic association studies in asthma and related phenotypes. J Hum Genet 2010; 55(6):342-9.
48. Chan IH, Tang NL, Leung TF, Huang W, Lam YY, Li CY, et al. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. Allergy 2008; 63(8):1031-9.
49. Kim ES, Kim SH, Kim KW, Park HS, Shin ES, Lee JE, et al.  Involvement  of  Fc(epsilon)R1beta  gene polymorphisms in susceptibility to atopy in Korean children with asthma. Eur J Pediatr 2009; 8(12):1483-90.
50. Kim SH, Bae JS, Holloway JW, Lee JT, Suh CH, Nahm DH, et  al.  A polymorphism of MS4A2  (-  109T >  C) encoding the beta-chain of the high-affinity immunoglobulin E receptor (FcepsilonR1beta) is associated with a susceptibility to aspirin-intolerant asthma. Clin Exp Allergy 2006; 36(7):877-83.
51. Shirakawa T, Mao XQ, Sasaki S, Enomoto T, Kawai M, Morimoto K, et al. Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. Hum Mol Genet 1996, 5(8):1129-30.
52. Wang  L,  Cui  T:  Relationship  between  FcεRIβ  gene polymorphism  and  juvenile  allergic  asthma  in  Hubei Area. J Huazhong Univ Sci Tech 2003, 32(3):332-5.
53. Zeng L, Zhou S, Kuang J, Rao W. Study on mutation of β chain of high-affinity IgE receptor gene E237G in asthma patients. Acta Academiae Med Jiangxi 2001, 41(5):43-5.
54. Zhao K, HJ. C, Zhao F, Sun M, Fu W. Analysis of gene mutation for high affinity immunoglobulin E receptor chain in asthmatic children. J Clinical Pediatrics 2004,22(12):794-7.
55. Li H, Xiaoyan D, Quanhua L, Jie L, Yixiao B. Single- nucleotide   polymorphisms   in   genes   predisposing   to asthma in children of Chinese Han nationality. J Investig Allergol Clin Immunol 2009; 19(5):391-5.
56. Zhao K, Lu J, Wang Z, Guo Y, Yu L, Fu W. Association between FcεRI-β gene promoter polymorphism and total serum IgE levels of asthma in children. Chin J Practical Pediatrics 2004, 19(12):744-6.
57. Huang HR, Zhong YQ, Wu JF. The association between IFN-gamma and IL-4 genetic polymorphisms and childhood susceptibility to bronchial asthma. Gene 2012;494(1):96-101.
58. Jiao  G,  Liu  X,  Ma  Y.  Association  between  bronchial asthma and the interferon gamma +874(A/T)gene polymorphism. J Harbin Med Univ 2011, 45(3):243-6.
59. Zheng BQ, Wang GL, Yang S, Lu YQ, Liu RJ, Li Y. [Study of genetic susceptibility in 198 children with asthma].  Zhongguo  Dang  Dai  Er  Ke  Za  Zhi  2012;14(11):811-4.
60. Godava M, Kopriva F, Bohmova J, Vodicka R, Dusek L, Cvanova M, et al. Association of STAT6 and ADAM33 single nucleotide polymorphisms with asthma bronchiale and IgE level and its possible epigenetic background. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2012; 156(3):236-47.
61. Sharma S, Nagarkatti R, C BR, Niphadkar PV, Vijayan V, Sharma SK, et al: A_16_C haplotype in the FcepsilonRIbeta gene confers a higher risk for atopic asthma  in  the  Indian  population.  Clin  Genet  2004;66(5):417-25.
62. Movahedi  M,  Mahdaviani  SA,  Rezaei  N,  Moradi  B, Dorkhosh S, Amirzargar AA. IL-10, TGF-beta, IL-2, IL-12,  and  IFN-gamma  cytokine  gene  polymorphisms  in asthma. J Asthma 2008; 45(9):790-4.
63. Li X, Zhang Y, Zhang J, Xiao Y, Huang J, Tian C, et al: Asthma susceptible genes in Chinese population: a meta- analysis. Respir Res 2010; 11:129.
64. Thornton A, Lee P. Publication bias in meta-analysis: its causes   and   consequences.   J   Clin   Epidemiol   2000;53(2):207-16.


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