The Levels of Serum Biomarkers in Stable Asthma Patients with Comorbidities

  • Emel Ceylan Department of Pulmonary Medicine, Adnan Menderes University Medical School, Aydın, Turkey http://orcid.org/0000-0002-4723-2285
  • Sertan Bulut Department of Pulmonary Medicine, Atatürk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey
  • Mustafa Yilmaz Department of Biochemistry, Adnan Menderes University Medical School, Aydın, Turkey
  • Hüseyin Örün Department of Pulmonary Medicine, Adnan Menderes University Medical School, Aydın, Turkey
  • Fisun Karadağ Department of Pulmonary Medicine, Adnan Menderes University Medical School, Aydın, Turkey
  • İmran Kurt Ömürlü Department of Biostatistics, Adnan Menderes University Medical School, Aydın, Turkey
  • Sevin Kirdar Department of Clinical Microbiology, Adnan Menderes University Medical School, Aydın, Turkey
  • Aslıhan Karul Department of Biochemistry, Adnan Menderes University Medical School, Aydın, Turkey
Keywords: Asthma, Biomarkers, Comorbidities, Serum interleukin 6, Serum interleukin 8

Abstract

The effects of comorbidities on systemic inflammation markers in stable asthmatics and the consequences of such effects have not been well evaluated. We aimed to evaluate the effect of comorbidities on clinical manifestations and systemic inflammation in asthmatic patients under control. The study group consisted of asthmatic patients who applied to our pulmonology outpatient clinic and volunteered to participate. 120 clinically stable asthma patients (71 females and 49 males) and 35 healthy controls (19 females and 16 males) with similar age, gender, and body mass index distributions were admitted to the study. The levels of osteopontin, interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 13 (IL-13), eosinophilic cationic protein, adiponectin, and high-sensitivity C-reactive protein of the individuals were evaluated using commercial ELISA kits by taking venous blood samples. Of 120 asthmatic subjects, 47 (39, 2%) had comorbidities and allergic rhinitis (15%) coexisted most frequently. Other comorbidities associated with asthma were gastroesophageal reflux, sinusitis, hypertension, diabetes, gastritis, and peptic ulcus respectively. There was no physician-diagnosed comorbidity in the control group. The levels of IL-6 and IL-8 were found higher in asthma group with comorbidities when compared to those with no comorbidities (p were 0.032 and 0.046, respectively). Comorbidities interfere with the diagnosis and treatment of asthma, besides affecting the disease control. Our findings suggest the possibility of the impact of comorbidities on systemic inflammation markers, especially IL-6 and IL-8. To evaluate the impact of comorbidities on asthma control and systemic markers, further studies are needed.

Author Biographies

Emel Ceylan, Department of Pulmonary Medicine, Adnan Menderes University Medical School, Aydın, Turkey

Department of Pulmonary Medicine, 1st author

Sertan Bulut, Department of Pulmonary Medicine, Atatürk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey

Department of Pulmonary Medicine, 2nd

Mustafa Yilmaz, Department of Biochemistry, Adnan Menderes University Medical School, Aydın, Turkey

Department of  Biochemistry, 3rd

Hüseyin Örün, Department of Pulmonary Medicine, Adnan Menderes University Medical School, Aydın, Turkey

Department of Pulmonary Medicine, 4th

Fisun Karadağ, Department of Pulmonary Medicine, Adnan Menderes University Medical School, Aydın, Turkey

Department of Pulmonary Medicine, 5th author

İmran Kurt Ömürlü, Department of Biostatistics, Adnan Menderes University Medical School, Aydın, Turkey

Department of Biostatistics, 6th

Sevin Kirdar, Department of Clinical Microbiology, Adnan Menderes University Medical School, Aydın, Turkey

Department of Clinical Microbiology,7th

Aslıhan Karul, Department of Biochemistry, Adnan Menderes University Medical School, Aydın, Turkey

Department of  Biochemistry, 8th

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Published
2019-02-02
How to Cite
1.
Ceylan E, Bulut S, Yilmaz M, Örün H, Karadağ F, Ömürlü İmran, Kirdar S, Karul A. The Levels of Serum Biomarkers in Stable Asthma Patients with Comorbidities. Iran J Allergy Asthma Immunol. 18(1):27-37.
Section
Original Article(s)