Increased Total Serum Immunoglobulin E in Children Developing Mycoplasma pneumoniae-related Extra-pulmonary Diseases

2 Department of Pediatrics, ASST Melegnano e Martesana, Vizzolo Predabissi, Milano, Italy

  • Dimitri Poddighe Department of Pediatrics, IRCCS Fondazione Policlinico San Matteo e Universita’ Degli Studi di Pavia, Pavia, Italy AND Department of Pediatrics, ASST Melegnano e Martesana, Vizzolo Predabissi, Milano, Italy http://orcid.org/0000-0001-6431-9334
  • Elena Virginia Comi Department of Pediatrics, ASST Melegnano e Martesana, Vizzolo Predabissi, Milano, Italy
  • Ilaria Brambilla Department of Pediatrics, IRCCS Fondazione Policlinico San Matteo e Universita’ Degli Studi di Pavia, Pavia, Italy
  • Amelia Licari Department of Pediatrics, IRCCS Fondazione Policlinico San Matteo e Universita’ Degli Studi di Pavia, Pavia, Italy
  • Paola Bruni Department of Pediatrics, ASST Melegnano e Martesana, Vizzolo Predabissi, Milano, Italy
  • Gian Luigi Marseglia Department of Pediatrics, IRCCS Fondazione Policlinico San Matteo e Universita’ Degli Studi di Pavia, Pavia, Italy
Keywords: Children, Extra-pulmonary diseases, Immunoglobulin E, Mycoplasma pneumoniae, Post-infectious immune-mediated diseases

Abstract

Mycoplasma pneumoniae has been recognized to be involved in several extra-pulmonary diseases, but the underlying immunologic mechanisms are still largely unknown. Recently, we observed a significant elevation of serum Immunoglobulin E (IgE) in a small group of these children. Here, we assessed total serum IgE levels in children affected with Mycoplasma pneumoniae-related extra-pulmonary diseases. We prospectively collected the data of 162 children admitted to the hospital (because of respiratory infections or extra-pulmonary diseases) who were evaluated for Mycoplasma pneumoniae serology and total serum IgE levels, concomitantly. Based upon clinical and serology aspects, 3 groups of children were identified: I) with non-mycoplasma respiratory disease; II) with mycoplasma-related respiratory diseases; III) with extra-pulmonary diseases related to concomitant/recent Mycoplasma pneumoniae infection. Interestingly, children with Mycoplasma pneumoniae-related extra-pulmonary diseases showed a significant elevation of total serum IgE. In particular, patients developing Mycoplasma pneumoniae-related extra-pulmonary diseases (group III) showed significantly higher level of IgE than both previous groups (p<0.001 vs. group I; p<0.01 vs. group II). In conclusion, hospitalized children diagnosed with Mycoplasma pneumoniae-related extra-pulmonary diseases resulted to have significantly increased serum IgE compared to children developing respiratory illnesses only.

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Published
2018-10-09
How to Cite
1.
Poddighe D, Comi E, Brambilla I, Licari A, Bruni P, Marseglia GL. Increased Total Serum Immunoglobulin E in Children Developing Mycoplasma pneumoniae-related Extra-pulmonary Diseases. ijaai. 17(5):490-6.
Section
Brief Communication