Iranian Journal of Allergy, Asthma and Immunology 2017. 16(4):307-312.

Decreased Sensitization to Aeroallergens among Southwestern Iranian Male Farmers
Mozhgan Moghtaderi, Mona Torab Jahromi, Shirin Farjadian, Payam Ghassemi, Saeed Hosseini Teshnizi


Farmers are usually exposed to various inhaled allergens like pollens, mites, molds, and animal dander in their working environment which may lead to allergic rhinitis, asthma and urticaria. The purpose of this study was to identify sensitization to various aeroallergens in farmers and their occupational allergy symptoms. This cross sectional study included 103 male farmers and 100 non-farmer healthy controls. The work-related symptoms of farmers were recorded with a questionnaire. Spirometry and skin prick tests with 15 commercial allergen extracts were performed in both farmers and controls. The rate of sensitization to at least one of the applied aeroallergens was 47.6% in farmers compared to 65% in the control group (OR=0.48; CI 95%, 1.08 to 2.07) according to skin prick tests, after adjusting for age. Occupational allergy symptoms were reported by 54.3% farmers. Mean FEV1/FVC was significantly lower in farmers than in controls (p<0.001). The results of this study showed that farmers had no increased risk of sensitization to aeroallergens. Sensitization to pollens was more prevalent than to mites among the farmers in our study and smoking was an important predisposing factor in farmers who suffered from occupational allergy symptoms.


Farmers; Lung function; Mite; Pollen; Skin test; Workplace

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1.Sudre B, Vacheyrou M, Braun-Fahrländer C, Normand AC, Waser M, Reboux G, et al.; PASTURE study group. High levels of grass pollen inside European dairy farms: a role for the allergy-protective effects of environment? Allergy 2009; 64:1068-1073.

2. Müsken H, Franz JT, Wahl R, Paap A, Cromwell O, Masuch G, Bergmann KC. Sensitization to different mite species in German farmers: in vitro analyses. J Investig Allergol Clin mmunol 2003; 13:26-35(2003).

3. Wiszniewska M, Tymoszuk D, Nowakowska-Świrta E, Pałczyński C, Walusiak-Skorupa J. Mouldsensitisation among bakers and farmers with work-related respiratory symptoms. Ind Health 2013; 51:275-284.

4. Roussel S, Sudre B, Reboux G, Waser M, Buchele G, Vacheyrou M, et al. .Exposure to moulds and actinomycetes in Alpine farms: a nested environmental study of the PASTURE cohort. Environ Res 2011; 111:744-750.

5. Hoppin JA, Umbach DM, London SJ, Alavanja MC, Sandler DP.Animal production and wheeze in the Agricultural Health Study: interactions with atopy, asthma, and smoking. Occup Environ Med 2003; 60(8):e3.

6. Zuskin E, Schachter EN, Mustajbegovic J. Int Arch Occup Environ Health 1993; 64:5521-552 6.

7. Omland Ø. Exposure and respiratory health in farming in temperate zones –a review of the literature. Ann Agric Environ Med 2002; 9: 119–136.

8. Eduard W, Schlünssen V, Sigsgaard T, Omland Ø, Pearce N, Douwes J. Can selection explain the protective effects of farming on asthma?Ann Agric Environ Med 2015; 22(3):467-469.

9. Elholm G, Schlünssen V, Doekes G, Basinas I, Bibby BM, Hjort C, et al. Become a farmer and avoid new allergic sensitization: adult farming exposures protect against new-onset atopic sensitization.J Allergy Clin Immunol 2013; 132:1239-1241.

10. Abu Sham'a F, Skogstad M, Nijem K, Bjertness E, Kristensen P.Lung function and respiratory symptoms in male Palestinian farmers. Arch Environ Occup Health 2010; 65:191-200.

11. Senthilselvan A, Chénard L, Grover V, Kirychuk SP, Hagel L, Ulmer K, et al. Excess longitudinal decline in lung function in grain farmers. J Agromedicine 2010; 15:157-165. 

12. Lung function testing: selection of reference values and interpretative strategies. American Thoracic Society. Am Rev Respir Dis 1991; 144: 1202-1218.

13. Remes ST, Iivanainen K, Koskela H, Pekkanen J. Which factors explain the lower prevalence of atopy amongst farmers’ children? Clin Exp Allergy2003; 33: 427-434.

14. Braun-Fahrlander C, Riedler J, Herz U, Eder W, Waser M, Grize L, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347:869-877.

15. Perkin MR, Strachan DP. Which aspects of the farming lifestyle explain the inverse association with childhood allergy? J Allergy Clin Immunol 2006; 117: 1374-1381.

16.Portengen L, Preller L, Tielen M, Doekes G, Heederik D.Endotoxin exposure and atopic sensitization in adult pig farmers.J Allergy Clin Immunol 2005; 115:797-802.

17. Chatzi L, Prokopakis E, Tzanakis N, Alegakis A, Bizakis I, Siafakas N, et al. Allergic rhinitis, asthma, and atopy among grape farmers in a rural population in Crete, Greece. Chest 2005; 127:372-178.

18. Migueres M, Dávila I, Frati F, Azpeitia A, Jeanpetit Y, Lhéritier-Barrand M, et al.  Types of sensitization to aeroallergens: definitions, prevalences and impact on the diagnosis and treatment of allergic respiratory disease. Clin Transl Allergy 2014; 4:16.

19. Hage-Hamsten M van, Johansson SGO, Zetterström O. Predominance of mite allergy over allergy to pollens and animal danders in farmingpopulation. Clin Allergy 1987; 17, 417-423.

20. Blainey AD, Topping MD, Ollier S, Davies RJ: Respiratory symptoms in arable farmworkers: role of storage mites. Thorax 1998; 43, 697-702.

21. Iversen M, Korsgaard J, Hallas T, and Dah R: Mite allergy and exposureto storage mites and house dust mites in farmers. Clin Exp Allergy 1990; 20, 211-219.

22. Radon K, Garz S, Schottky A, et al. Lung function and work-related exposure in pig farmers with respiratory symptoms. J Occup Environ Med 2000; 42:814–820.

23. Riedler J, Braun-Fahrländer C, Eder W, Schreuer M, Waser M, Maisch S, et al.: Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001; 358, 1129-1133.

24. Choudat D, Goehen M, Korobaeff M, Boulet A, Dewitte JD, Martin MH. Respiratory symptoms and bronchial reactivity among pig and dairy farmers. Scand J Work Environ Health 1994; 20:48–54.

25. Dalphin JCDubiez AMonnet EGora DWesteel VPernet D, et al. Prevalence of asthma and respiratory symptoms in dairy farmers in the French province of the Doubs. Am J Respir Crit Care Med 1998; 158:1493–1498.

26. Danuser B. Respiratory symptoms in Swiss farmers: an epidemiological study of risk factors. Am J Ind Med 2001; 39:410–418.

27. Valcin M, Henneberger PK, Kullman GJ, Umbach DM, London SJ, Alavanja MC, et al.  Chronic bronchitis among nonsmoking farm women in the agricultural health study. J Occup Environ Med 2007; 49:574-583.

28. Dalphin JC, Bildstein F, Pernet D, Dubiez A, Depierre A:Prevalence of chronic bronchitis and respiratory function in a group ofdairy farmers in the French Doubs province. Chest 1998; 95, 1244-1247.

29. Chiriac AM, Bousquet J, Demoly P. In vivo methods for the study and diagnosis of allergy. In: Adkinson F, Bruce S. Bochner, William W. Busse, Stephen T, editors. Middleton’s Allergy Principles and Practice.8th ed. Philadelphia: Mosby Elsevier; 2013. 1119-1129.

30. Droste J, Myny K, Van Sprundel M, Kusters E, Bulat P, Braeckman L, et al.  Allergic sensitization, symptoms, and lung function among bakery workers as compared with a nonexposed work population. J Occup Environ Med 2003; 45:648-655.


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