Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 19 S1 2020 05 17 3 6 Abdol Majid Cheraghali Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran Hassan Abolghasemi Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Peyman Eshghi Faculty of Medicine, Shahid Beheshti University of Medical Sciences and Iran Blood Transfusion Organization; Tehran, Iran 2020 04 19 2020 04 27 Abstract Abstract Abstract Abstract Abstract https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2799

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 19 S1 2020 05 17 1 2 Maryam Nourizadeh Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran Mohammad Javad Rasaee Department of Clinical Biochemistry, School of Medical Sciences, Tarbiat Modares University (TMU), Tehran, Iran Mostafa Moin Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran 2020 05 06 2020 05 08 Abstract Abstract Abstract Abstract https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2817

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 19 S1 2020 05 17 7 9 Ali Esmaeili Vardanjani Department of Critical Care Nursing and Management, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran AND Department of Nursing, Faculty Member, Hamadan University of Medical Sciences, Hamadan, Iran Siamak Moayedi Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, U.S.A Mohammad Golitaleb Department of Critical Care Nursing, School of Nursing, Arak University of Medical Sciences, Arak, Iran 2020 03 27 2020 04 24 Abstract Abstract Abstract Abstract https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2760

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 19 S1 2020 05 17 10 12 EN Farzaneh Dastan Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Atefeh Abedini Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Shahram Shahabi Department of Research and Development, SHC-Hyland's Inc., Los Angeles, California, U.S.A Arda Kiani Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Ali Saffaei Student Research Committee, Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ahad Zare Sarem Cell Research Center (SCRC), Sarem Women's Hospital, Tehran, Iran AND Department of Immunology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran 2020 04 26 2020 05 11 Abstract Abstract Abstract Abstract   https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2805

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 19 S1 2020 05 17 13 17 Seyed-Mohammad Ghahestani Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran Javad Mahmoudi Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Sakineh Hajebrahimi Research Center for Evidence-Based-Medicine, Iranian EBM Center, A JBI Affiliated Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran AND Department of Urology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Amir-Babak Sioofy-Khojine Research Center for Evidence-Based-Medicine, Iranian EBM Center, A JBI Affiliated Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran AND Faculty of Medicine and Life Technologies, Tampere University, Tampere, Finland AND Research Center for Infectious and Tropical Disease, Tabriz University of Medical Sciences, Tabriz, Iran Hanieh Salehi-Pourmehr Research Center for Evidence-Based-Medicine, Iranian EBM Center, A JBI Affiliated Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran Fatemeh Sadeghi-Ghyassi Research Center for Evidence-Based-Medicine, Iranian EBM Center, A JBI Affiliated Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iranersity of Medical Sciences, Tabriz, Iran 7 Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Hadi Mostafaei Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria 2020 04 11 2020 04 22 The new virus SARS-CoV-2 is savagely spreading out over the world. The biologic studies show that the target receptor for the virus might be angiotensin-converting enzyme 2 (ACE2). This peptide is responsible for converting angiotensin II (Ang II), which is a profoundly active peptide, into Ang 1-7 with quite a balancing barbell function. It is emphasized that the direct target of the virus is ACE2 underlining the obvious difference with ACE. Nevertheless, we hypothesized that a back load build up effect on Ang II may usurp the ACE capacity and subsequently leave the bradykinin system unabated. We think there are clinical clues for dry cough and the presumed aggravating role of ACE inhibitors like captopril on the disease process. Thereby, we speculated that inhibition of bradykinin synthesis and/or blockade of bradykinin B2 receptor using Aprotinin/ecallantide and Icatibant, respectively, may hold therapeutic promise in severe cases and these molecules can be advanced to clinical trials. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2785

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 19 S1 2020 05 17 18 26 EN Reza Jafari Solid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran AND Department of Immunology and Genetics, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Mostafa Moin Immunology, Asthma, and Allergy Research Institute, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran Fatah Kashanchi School of Systems Biology, Laboratory of Molecular Virology, George Mason University, Manassas, VA, U.S.A Alireza Ranjbar School of Systems Biology, Laboratory of Molecular Virology, George Mason University, Manassas, VA, USA 5 Institute of Interventional Allergology and Immunology, Bonn/Cologne, Bonn, Germany AND International Prof. Dr. Alireza Yalda Foundation in Medical Sciences, Bonn/Cologne, Bonn, Germany 2020 01 24 2020 03 30 In light of various supports of prodigious figures in the field of immunology and allergy, the subject area has been faced a great leap during the last century. The current state of the discipline owes an abundant appreciation for the scholars motivated in escalating the true nature of the science, who left no stone unturned in improving the general common sense and understanding of the human knowledge in general, and immunology and allergy in particular. Professor Reza Farid Hosseini is among the dignitaries who invested his life and energy on weaving the tapestry of the immunology and allergy. He delivered a great deal of influence on the field by his ethical devotion to science and was a significant contributor in the realms of the human immune system. His presence drastically rehabilitated the place of the Immunology in Iran, and the current paper seeks to review the personal and academic life of Professor Reza Farid Hosseini in honor and appreciation for his in-depth involvement in the field. The paper summarizes Professor Farid’s childhood, school, and higher education, compilations, and translation of books, his contribution to the research both inside and outside of Iran, and scientific activities of Dr. Farid Hosseini. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2691

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 19 S1 2020 05 17 27 42 Javad Poursamimi Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AND Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Zhaleh Shariati-Sarabi Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AND Department of Internal Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Jalil Tavakkol-Afshari Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Seyed Ahmad Mohajeri Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran Mojgan Mohammadi Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AND Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 2019 11 05 2019 12 06 It has been reported that patients with arthritis, osteoarthritis, atherosclerosis, coronary artery disease, brain ischemia, diabetes, and inflammatory bowel disease (IBD) suffer from pro-inflammatory and oxidant related responses. Therefore, anti-inflammatory and anti-oxidant therapies are used to improve the quality of life of the patients. Saffron is a herbal drug that has immunomodulatory and antioxidant properties. Hence, Saffron and its components have been proposed as therapeutic agents for the treatment of the diseases. Therefore, this review article was designed to collect recent information regarding the effects of saffron and its components on the amelioration of the inflammatory symptoms in the autoimmune and non-autoimmune diseases and anti-cancerous effects from 1999 up to now via searching the Pubmed, Google Scholar, and Scopus databases. Due to fact that several investigations have reviewed the roles played by Saffron on autoimmune and non-autoimmune diseases such as multiple sclerosis, mood disorders, and Alzheimer's disease, this review article focuses on other diseases to keep the novelty of the present review for readers. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2586

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 19 S1 2020 05 17 43 54 EN Peyman Bemani Department of Immunology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran AND Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran Zahra Amirghofran Department of Immunology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran AND Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Eskandar Kamali-Sarvestani Department of Immunology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran AND Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 2019 10 04 2019 12 03 Though the exact etiology of rheumatoid arthritis (RA) is unknown, the contribution of immune cells in the disease process is completely acknowledged. T helper (Th) 1 and Th17-related cytokines are required for the disease development and progression, while Th2 and regulatory T cells (Tregs)-derived cytokines are protective. Studies have shown that sodium benzoate (NaB) can switch the balance of Th cell subsets toward Th2 and Tregs. The present study aimed to evaluate the possible effects of NaB on the expression of CD4+T cells-related cytokines and transcription factors in splenocytes derived from an animal model of RA, adjuvant-induced arthritis (AIA). AIA was induced in rats by injection of Freund's adjuvant containing mycobacterial antigens (Mtb). Splenocytes were isolated from AIA rats and restimulated ex vivo with Mtb in the presence or absence of NaB for 24 h. To determine the effects of NaB on the expression of T cells-related cytokine and transcription factor genes, real-time PCR was performed. NaB treatment of Mtb-stimulated splenocytes derived from arthritic rats resulted in significant increases in the gene expressions of Tregs-related cytokines (IL-10 and TGF-β) and Foxp3 transcription factor, and significant decreases in the expression of Th1-related cytokines (TNF-α and IFN-γ) and the T-bet transcription factor. The ratios of Th1/Th2 (IFN-γ/IL-4), Th1/Treg (IFN-γ/TGF-β and IFN-γ/IL-10) and Th17/Treg (IL-17/IL-10 and IL-17/IL-10+TGF-β)-related cytokines were 2018 06 14 2018 09 25 Systemic sclerosis (SSc) is characterized by excessive production of collagens by fibroblasts that leads to vast fibrosis. Resistance to apoptosis is one of the possible underlying mechanisms of fibrosis in these patients. Survivinis involved in inhibition of apoptosis and aberrantly functions in SSc. Since dysregulation of survivin-targeting microRNAs (miRNAs) has frequently been observed in cancer and some autoimmune disorders, this study aimed to investigate their expression status in dermal fibroblasts from SSc patients. DiffuseSSc patients were selected according to American College of Rheumatology criteria. Isolated fibroblasts from 10 SSc and 10 healthy skin biopsies were cultured. After examining purity of the cells, mRNA and miRNAs extraction was performed followed by complementary DNA (cDNA) synthesis. Relative expressions ofsurvivin mRNA, miR-16-5p, miR-320a, miR-218-5p, miR-708-5p and miR-542-3p were analyzed using real time PCR. Survivin mRNA expression was significantly 1.85-fold upregulated in fibroblasts from SSc patients compared with healthy controls (p=0.046). Among the studied miRNAs, miR-542-3p expression was significantly decreased (p=0.033), while enhanced expression of miR-708-5p was observed in SSc fibroblasts (p=0.05) in comparison to healthy subjects. Downregulation of miR-542-3p significantly correlated with survivin overexpression (r=˗0.45, p=0.049). Downregulation of miR-542-3p that is correlated with higher surviving expression levels might be a possible cause of apoptosis resistance in SSc fibroblasts, hence providing a new understanding of the disease pathogenesis. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1998 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/1998/1410

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 18 2 2019 04 01 182 189 EN Fateme Vafashoar Department of Immunology, Iran University of Medical Sciences, Tehran, Iran Kazem Mousavizadeh Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran Hadi Poormoghim Scleroderma Study Group, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran Abbas Tavasoli Department of Pathobiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Tahereh Musavi Shabestari Institute of Immunology and Infectious Diseases, Antimicrobial Resistance Research Center, Iran University of Medical Sciences, Tehran, Iran Sayed Javadmoosavi Air Pollution Research Centre, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Nazanin Mojtabavi Department of Immunology, Iran University of Medical Sciences, Tehran, Iran AND Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran 2018 05 13 2018 07 08 Systemic sclerosis is a fibrotic autoimmune disease in which aberrant remodeling of the extracellular matrix in organs disturbs their functionalities. The aim of this study was to investigate the expression of gelatinases on systemic sclerosis. Consequently, a mouse model of systemic sclerosis was employed and the gelatinolytic activity of gelatinases was evaluated on the fibrotic tissues of this model. Two groups of ten mice were considered in this work: a group of systemic sclerosis model and control group. For the generation of systemic sclerosis model, mice received bleomycin, while the control group was subjected to phosphate buffered saline (PBS) reception. Mice were tested for fibrosis by using trichrome staining, hydroxyproline measurement and α-SMA detection in tissue sections. Additionally, the gelatinolytic activity of matrix metalloproteinase 2 and matrix metalloproteinase 9 were measured using gelatin zymography in lungs and skin tissue homogenates. The obtained results indicated that subcutaneous injection of bleomycin-induced fibrosis in skin and lung tissues of mice. Pro and active forms of matrix methaloproteinase 9 were increased in fibrotic lung tissues (p<0.05 and p<0.01, respectively), while, the gelatinolytic activity of MMP2 was unaffected in these tissues. Additionally, in skin tissues of bleomycin-treated animals, both pro and active forms of MMP9 and MMP2 were increased (p<0.05). Pro and active forms of gelatinases increase differently in skin and lung tissues of bleomycin-induced scleroderma. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1956 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/1956/1404

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 18 2 2019 04 01 190 199 EN Sanaz Mami Department of Medical Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Farshid Yeganeh Department of Medical Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Elnaz Farahani Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Ali Anissian Department of Veterinary Pathology, Islamic Azad University, Abhar Branch, Abhar, Iran Mustafa Haji Molla Hoseini Department of Medical Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2018 06 12 2018 11 24 Contrasting studies are reported on the induction of IL-10 and IFN-γ via chitin microparticles (CMPs) during immune stimulation. Our previous studies have shown marked protection among CMP treated Leishmania-infected mice via regulated IL-10/IFN-γ response, at the present study, once more, examined the inconsistent responses regarding the immunologic response of CMPS. To verify whether CMPs could indeed up-regulate IL-10/IFN-γ axis, isolated spleen cells from the myelin oligodendrocyte glycoprotein (MOG) induced experimental autoimmune encephalomyelitis (EAE) mice were cultured in the presence of MOG peptide and/or CMPs. The effects of CMPs on IL-10, IFN-γ and IL-17 production were evaluated by Enzyme-linked Immunosorbent Assay (ELISA). Moreover, GATA binding protein 3 (Gata3), T-box transcription factor TBX21 (Tbx21), and RAR-related orphan receptor gamma (RORγT) expressions (real-time PCR) were investigated. MOG alone stimulated the production of IFN-γ (p≤0.004) but not, IL-10 (p≤0.140). MOG/chitin stimulation resulted in a significant increase in IFN-γ and IL-10 levels, respectively; (p≤0.004 and p≤0.003) rather than MOG. Additionally, the expression of Tbx21 (p≤0.001), but not Gata3 (p≤0.08), was increased in the MOG/chitin-treated spleen cells. All in all, CMP supports Gata3 independent IL-10 production and promotes Tbx21 dependent IFN-γ induction. These results, alongside our previous data, indicate that CMPs has particular adjuvant effects. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1986 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/1986/1415

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 18 2 2019 04 01 200 208 EN Fariba Raygan Department of Cardiology, Kashan University of Medical Sciences, Kashan, Iran Hanieh Mohammadi Students’ Research Center, Kashan University of Medical Sciences, Kashan, Iran Aniseh Etminan Students’ Research Center, Kashan University of Medical Sciences, Kashan, Iran Mojtaba Sehat Department of Community Medicine, Kashan University of Medical Sciences, Kashan, Iran Hassan Nikoueinejad Department of Immunology, Baqiyatallah University of Medical Sciences, Tehran, Iran AND Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran 2017 11 07 2019 01 12 Unstable angina pectoris (USAP) is a complex condition in which widespread coronary inflammatory processes have important implications for clearer understanding of its pathogenesis and also its treatment. This study aimed at evaluating the diagnostic as well as prognostic value of serum inflammatory markers of pentraxin-3 (PTX-3), Von Willebrand Factor (vWf) and C-X-C Motif Chemokine Ligand 13 (CXCL13) in such patients. Out of sixty-nine patients, thirty-nine had USAP, thirty had stable angina pectoris (SAP), and thirty-nine were healthy controls. For all participants, serum PTX-3, vWf and CXCL13 levels were measured using ELISA. For each patient with USAP, the Thrombolysis in Myocardial Infarction (TIMI) and the scores of Global Registry of Acute Coronary Events (GRACE) were calculated to determine the severity of the disease. We, then, analyzed the relation of PTX-3, vWf and CXCL13 levels with TIMI and GRACE scores in patients with USAP. Serum PTX-3, vWf and CXCL13 levels were significantly higher in USAP group than those in either SAP or control groups (p˂0.001). Strong correlation was observed between CXCL13 level and TIMI risk score (p=0.019). In receiver operating characteristic (ROC) curves, area under the curve (AUC) values of PTX3, vWf and CXCL13 for detection of USAP were 0.755, 0.751, and 0.906, respectively. The levels of serum PTX3, vWf and CXCL13 increased in patients with USAP. The notable correlation implied that CXCL13 might be a sensitive and specific biomarker for the diagnosis of USAP as well as its severity. It might also show additional diagnostic values when measured in combination with vWf. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1720 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/1720/1407

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 18 2 2019 04 01 209 217 EN Majid Ghaderi Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Shahrbanoo Oryan Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Namdar Yousofvand Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran Akram Eidi Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran 2017 12 28 2018 09 09 Asthma is a chronic inflammatory disease of the airways of the lungs. Pomalidomide (POM) a therapy for multiple myeloma has been stated to have an anti-inflammatory effect. The main goal of the present study was to assess its possible effect on airway contraction and inflammation in a rat model of ovalbumin-induced asthma. Different groups of rats received saline or pomalidomide (0.4, 0.8 mg/kg) or dexamethasone (0.6 mg/kg). The asthma was induced by ovalbumin (OVA). Trachea contraction was assayed by organ bath system. Airway histology was assessed using hematoxylin and eosin method. Serum Tumor necrosis factor alpha (TNF-α) level was analyzed by Enzyme-Linked Immunosorbent Assay and Platelet-derived growth factor (PDGFα) Gene expressions were evaluated by Real-time PCR. Pomalidomide prevented ovalbumin-induced airway contraction and histopathological damage. In addition serum, TNF-α level was significantly (p<0.05) decreased in POM treated animals compared to control (asthmatic animals that received POM vehicle). Results indicate that POM prevented the PDGF expression induced by ovalbumin. In conclusion, we found that pomalidomide ameliorated the symptoms, histopathological changes and inflammatory markers induced by ovalbumin in asthmatic rats and these effects might be related to its anti-inflammatory properties. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1805 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/1805/1417

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 18 2 2019 04 01 218 224 Sholeh Etehad Asnaf Department of Cell and Molecular Biology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran