Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 4 2014 08 15 220 230 EN Zohre Jadali Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Bagher Eslami Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 16 A central role for T cells and their cytokines in the pathogenesis of psoriasis has been proposed; however, there are controversies over the details of this issue. The goal of this study is to summarise currently available data on the importance of T cells in psoriasis pathogenesis. A  systematic  review  of  the  English  medical  literature  was  conducted  by  searching PubMed, Embase, ISI Web of Knowledge, and Iranian databases including Iranmedex, and SID for studies on associations between the involvement of T cell subsets and psoriasis. The results of the present study indicate that alterations in the number and function of different subsets of T-cells are associated with psoriasis. It   appears   that   studies   on   T   cell   subsets   contributed   to   understanding   the immunopathogenesis  of  psoriasis.  In  addition,  it  may  have  provided  novel  therapeutic opportunities in ameliorating immunopathologies. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/452 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/452/385

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 4 2014 08 15 231 239 EN Cuicui Duan Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. Lijie Yang Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. Aili Li Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. Rui Zhao Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. Gui-Cheng Huo Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. 2015 10 16 Cow’s milk whey consists of many protein components and some of them are antigens to human and known to modulate immune responses. Enzymatic hydrolysis is a useful method to modify proteins with allergenicity. The objective of this study was to identify whether the in vitro enzymatic hydrolysis could reduce the allergenicity of whey protein concentrates (WPC). In  this study, WPC were hydrolyzed by trypsin and twenty-four BALB/c mice were divided into three groups and fed with WPC formula and WPC hydrolysates formula, while the control mice received milk-free diet. The results revealed that there was no significant difference between the body weights among all groups. WPC-fed mice produced an elevated spleen lymphocyte proliferation level than WPC hydrolysates-fed mice and also produced higher levels of WPC-specific IgE in intestinal tract and serum in comparison to WPC hydrolysates-fed mice and control group. Significant up-regulation of plasma histamine levels were also observed and showed the same trend with IgE. The secretions of IL-4 and IL-5 were significantly enhanced by WPC. WPC significantly suppressed  the  secretion of  IFN-γ  while hydrolysates of  WPC significantly increased the secretion of IFN-γ compared to control group. These results suggest that hydrolysis may play a role to reduce the allergenicity of WPC. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/451 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/451/386

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 4 2014 08 15 240 246 EN Zailatul Hani Mohamad Yadzir Allergy and Immunology Research Centre, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia Rosmilah Misnan Department of Biology, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia Noormalin Abdullah Allergy and Immunology Research Centre, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia Faizal Bakhtiar Allergy and Immunology Research Centre, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia Brenda Leecyous Allergy and Immunology Research Centre, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia Shahnaz Murad Allergy and Immunology Research Centre, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia 2015 10 16 Component-resolved  diagnosis (CRD) using microarray technology has recently been introduced  with the  aim to  improve diagnosis of allergy. The  aim of this study was to compare performance of this allergen microarray to those of an established extract-based skin prick testing (SPT). 45  patients  with  allergic rhinitis  were studied  (16 children  and  29  adults). SPT  to Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis extracts and allergen microarray ImmunoCAP ISAC were carried out for all patients. Forty out of 45 patients demonstrated positive SPT to all mite extracts tested. These 40 patients  were  considered  to  be  mite-  allergic based  on  the  positive  SPT  results. The remaining 5 patients with negative SPT to  any mite extracts were classified as non-mite allergic. Comparatively, based on the microarray results, only 34 mite-allergic patients had detectable serum IgE  to  at least one of the mite allergen components  tested whereas 6 patients with positive SPT to mite extracts showed no detectable IgE reactivity to any of the components  tested. One non-mite allergic patient had a positive test- Blo t 5.  Der p 10- positive patients also reacted to other cross-reactive tropomyosin from anisakis (Ani s 3) (25%), cockroach (Bla g 7) (50%) and shrimp (Pen m 1) (75%). CRD is a reliable tool for the diagnosis of allergy to mites. Der p 10 might be a useful indicator to identify a subset of mite-allergic patient that have additional sensitization due to cross-reactivity and thus allows selection of patients for immunotherapy. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/450 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/450/387

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 4 2014 08 15 247 255 EN Mahshid Sirjani Department of Clinical Nutrition and Dietetics, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Foroogh Azam Taleban Department of Clinical Nutrition and Dietetics, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Azita Hekmatdoost Department of Clinical Nutrition and Dietetics, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Zohreh Amiri Department of Basic Sciences/Biostatistics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Michael Pellizzon Research Diets, Inc., New Jersey, the United States of America. Mehdi Hedayati Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Katayoon Bidad Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Raheleh Shokouhi Shoormasti Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Zahra Pourpak Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 16 There has been considerable inconsistency regarding the potential relationship between dyslipidemia and bone metabolism. The inflammatory stimulation through the receptor activator of the nuclear factor kappa-B ligand (RANKL)/ receptor activator of the nuclear factor kappa-B (RANK)/ osteoprotegerin (OPG) pathway could be the infrastructural mechanism for hypercholesterolemia-induced bone loss. In this study, we investigated the effect of dyslipidemia on RANKL and OPG  alongside with pro-inflammatory cytokines. Thirty male C57Bl/6 mice (4 weeks old) were randomized to two purified diet groups (15 animals in each group), high fat, low carbohydrate diet (HFLCD) and its matched low fat, high carbohydrate diet (LFHCD). After 12 weeks of feeding in standard situations, the plasma concentration of lipid profile, interleukin (IL)1Beta, IL-6, tumor  necrosis factor-alpha (TNF-α) and RANKL, OPG,  and RANKL: OPG ratio were measured. In the present study, although the body weight significantly increased during 12 weeks in HFLCD and LFHCD groups, there were no significant differences in food intake, food efficiency ratio and weight gain between the two groups. The LFHCD group had significantly higher median RANKL and RANKL/OPG ratio. There was no significant difference in plasma IL-1β, IL-6 and TNF-α concentration between LFHCD and HFLCD groups. These unexpected findings from  LFHCD,  that  seem to  be as a result of its higher carbohydrate proportion  in comparison to HFLCD,  implicate dietary carbohydrate rather than dietary fat as a more significant nutritional factor contributing to change in RANKL level and RANKL: OPG ratio. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/449 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/449/388

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 4 2014 08 15 256 264 EN Soodeh Razeghi Jahromi Sina Hospital, Multiple Sclerosis Research Center- Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran AND Shefa Neuroscience Research Center, Tehran, Iran. Seyed Rafi Arrefhosseini Department of Nutrition and Health, Tabriz University of Medical Sciences, Tabriz, Iran. Amir Ghaemi Shefa Neuroscience Research Center, Tehran, Iran AND Infectious Diseases Research Center, Department of Microbiology, Golestan University of Medical Sciences, Gorgan, Iran. Akram Alizadeh Tissue Engineering Department, Advanced Technology in Medicine,Tehran University of Medical Sciences, Tehran, Iran. Hedieh Moradi Tabriz Department of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mansoureh Togha Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AND Iranian Center of Neurological Research-Neuroscience Institute,Tehran University of Medical Sciences, Tehran, Iran. 2015 10 16 Experimental  allergic encephalomyelitis (EAE) is considered  as the murine model of multiple sclerosis. Daidzein a phytostrogenic compound of soy is known to impose immunomodulatory and antioxidative effects. We conducted this study to assess the potential protective and therapeutic effects of daidzein on allergic encephalomyelitis. C57BL/6 mice  were induced  with  allergic encephalomyelitis  using  myelin oligodendrocyte glycoprotein (35-55) and received daidzein or dimethyl sulfoxide as the vehicle control. To assess the protective effect of daidzein, the mice were administered with 20 mg/kg of daidzein from 21 days prior to 21 days post EAE induction on a daily basis. To evaluate the therapeutic effect of daidzein, mice were fed with 300 mg/kg daidzein after the appearance of the first clinical signs for 10 days. One day after the last gavage, the mice were sacrificed. Spleen and brain were removed for further histological and immunological analysis. Feeding mice with low dose of daidzein prior to disease induction did not affect disease severity. However, treating with high dose of daidzein after the onset of the disease reduced interferon-γ and interleukin-12 secretion, enhanced interleukin-10 production, suppressed lymphocyte proliferation, and decreased cytotoxicity as judged by lactate dehydrogenase release. In conclusion, daidzein reduced the extent of demyelination and disease severity. Chronic oral therapy with low dose of daidzein did not prevent experimental autoimmune encephalomyelitis. However, high doses of daidzein could prohibit disease exacerbation. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/448 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/448/389

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 4 2014 08 15 265 270 EN Behzad Heidari Department of Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Iran. Reza Amin Department of Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Iran AND Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Sara Kashef Department of Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Iran AND Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Soheila Alyasin Department of Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Iran AND Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Mozhgan Moghtaderi Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Maneli Aminshahidi Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Mehdi Kalani Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 2015 10 16 Inflammation of blood vessels is a characteristic feature of Kawasaki disease. Neutrophils play a key role in the inflammatory responses where movement of neutrophils toward the site of inflammation depends on CD11b/CD18 expression as adhesion molecules on these cells. The purpose of this study was to investigate CD11b/CD18 expression in patients with Kawasaki disease upon diagnosis and after treatment. The study included 20 children with Kawasaki disease aged from 3 months to 8 years. Mean fluorescence intensity of CD11b levels on diagnosis and at 1-2 and 6 weeks after intravenous  immunoglobulin  (IVIG)  therapy  was  measured  in  these  patients.  Level  of CD11b was measured in age-matched healthy children and febrile children (each 21) as negative and positive controls, respectively. Mean fluorescence intensity of CD11b in Kawasaki patients was lower than that of the control groups before and after 1-2 weeks of IVIG therapy. There were no significant differences in CD11b in Kawasaki patients either with aneurysm or without aneurysm. The CD11b levels at the diagnosis time and after treatment with IVIG in our patients with Kawasaki were lower than the control groups. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/447 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/447/390

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 4 2014 08 15 271 277 EN Mohammadali Saba Department of Internal Medicine, Kashan University of Medical Sciences, Kashan, Iran. Mohammad Reza Sharif Department of Pediatrics, Kashan University of Medical Sciences, Kashan, Iran. Hossein Akbari Trauma Research center, Department of Biostatistics and epidemiology, Kashan University of Medical Sciences, Kashan, Iran. Hassan Nikoueinejad Department of Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Maryam Ramazani Jolfaii Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran. 2015 10 16 It has been suggested that elevated serum level of YKL-40 could be a marker for asthma and its severity. Along with few published studies, we investigated its correlation with asthma and its severity as well as spirometric indices.114 patients with asthma and 114 healthy controls underwent the assessment of serum level of YKL-40 (by ELISA) and spirometric indices. Pearson's coefficient determined the correlation between the variables and multivariate linear regression analysis was used for adjusting the effect of different probable confounding factors.Serum levels of YKL-40 were significantly higher in the asthmatic patients compared to those in healthy people (p<0.001). We also found a significant correlation between YKL-40 serum level and spirometric indices even after adjusting the effects of other variables.We report for the first time in an Iranian population that YKL-40 may be a good diagnostic marker of asthma in serum. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/446 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/446/391

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 4 2014 08 15 278 285 EN Marzieh Tavakol Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Payam Mohammadinejad Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Ilaria Baiardini Allergy and Respiratory Diseases Clinic, DIMI, University of Genoa, IRCCS AOU San Martino-IST, Genova, Italy. Fulvio Braido Allergy and Respiratory Diseases Clinic, DIMI, University of Genoa, IRCCS AOU San Martino-IST, Genova, Italy. Mohammad Gharagozlou Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Asghar Aghamohammadi Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran AND Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Nabavi Department of Allergy and Clinical Immunology, Rasool-e-Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran. Abbas Dabbaghzade Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Zahra Tavakol Student ResearchCommittee,Kermanshah University of Medical Sciences, Kermanshah, Iran. Mohsen Afarideh Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Nima Rezaei Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran AND Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Masoud Movahedi Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 16 Chronic urticaria (CU) also known as chronic idiopathic urticaria results in a lowered quality of life (QoL). Disease specific questionnaires are necessary to assess QoL in CU patients. Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL) is the only available and validated disease specific questionnaire in the assessment of QoL in CU patients originally developed in Italian language. The aim of the current study was to develop the Persian version of the CU-Q2oL with an acceptable reliability and validity. Using the standard methods provided by guidelines, CU-Q2oL was translated into Persian. A total number of 110 patients with confirmed diagnosis of CU were asked to fill the questionnaire. Determination of scales was performed in addition to checking the data for internal consistency and known group validity. Urticaria activity score 7 (UAS-7) was used to assess the severity of the CU in the population study. The 6 dimensional scale of Persian CU-Q2oL was determined using the Exploratory Factor Analysis. About 68% of the variance was explained by these 6 factor structure higher than 59.9% of the original Italian version. All 6 factors showed acceptable internal consistency as measured by Cronbach α coefficient. There was a  significant  correlation  between  UAS-7  and  total  CU-Q2oL  score.  UAS7  and  the  presence  of angioedema were predictors of CU-Q2oL score. The Persian version of CU-Q2oL was shown to be a valid and reliable tool to be used in the future clinical studies. Cultural considerations must be kept in mind in adoption of CU-Q2oL to other languages. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/445 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/445/392

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 4 2014 08 15 286 289 EN Fariborz Zandieh Department of Asthma, Allergy and Immunology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Bahram Mirsaed Ghazi Department of Asthma, Allergy and Immunology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Anahita Izadi Department of Infectiousn Diseases, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Gharegozlu Department of Infectiousn Diseases, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Motahareh Aghajani Department of Asthma, Allergy and Immunology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mahdi Sheikh Department of Asthma, Allergy and Immunology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 16 Papillon-Lefevre syndrome (PLS) is a very rare genetic syndrome, and fewer than 500 cases have been reported in the world. Patients exhibit typical cutaneous involvement with hyperkeratosis, especially on the soles and palms, and early shedding of primary teeth. Internal organ involvements, such as liver abscesses, have been described in case reports. This  communication  represents  the  first  time  that  genetically  documented  PLS  with footprints of mycobacterium tuberculosis in liver and kidney is reported. T-Lymphocyte transformation Test with PHA was abnormal in this patient. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/444 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/444/393

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 4 2014 08 15 290 295 EN Nicolae Ovidiu Berghi Anima Medical Center, Bucharest, Romania. 2015 10 16 Opening frontiers has led in the last two decades to a massive migration of Romanians to Spain and Italy, two countries known to have large areas planted with olives. Romania owns large areas planted with ash forests. Because of cross-reactivity between these two trees belonging to the Oleaceae family and the big allergenic potential of olive pollens, after a number of years of residence in these countries, many Romanians will present allergic respiratory symptoms of rhinitis and asthma, both in the season of olive pollination and ash pollination. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/443 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/443/394

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 4 2014 08 15 296 297 EN Muammer Kara Department of Gastroenterology, Gata Haydarpasa Training Hospital, 34668 Uskudar-Istanbul, Turkey. Alpaslan Tanoglu Department of Gastroenterology, Gata Haydarpasa Training Hospital, 34668 Uskudar-Istanbul, Turkey. Ali Kutlu Department of Immunulogy and Allergy, Gata Haydarpasa Training Hospital, 34668 Uskudar-Istanbul, Turkey. Ozgur Sirkeci Department of Internal Medicine, Gata Haydarpasa Training Hospital, 34668 Uskudar-Istanbul, Turkey. Murat Kekilli Department of Gastroenterology, Hitit University, Corum Training and Research Hospital, Çorum, Turkey. 2015 10 16 LETTER TO THE EDITOR https://ijaai.tums.ac.ir/index.php/ijaai/article/view/442 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/442/395

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 4 2014 08 15 298 299 EN Sabir Hussain Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Tahir Ali Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. 2015 10 16 LETTER TO THE EDITOR https://ijaai.tums.ac.ir/index.php/ijaai/article/view/441 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/441/396