Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 5 2014 10 15 300 306 EN Esmaeil Mortaz Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands AND Chronic Respiratory Diseases Research Center and National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Department of Immunology, ShahidBeheshti  University of Medical Sciences, Tehran, Iran Mohammad Reza Masjedi Respiratory Diseases Research Center and National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Department of Immunology, ShahidBeheshti University of Medical Sciences, Tehran, Iran. Payam Tabarsi Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mihan Pourabdollah Chronic Respiratory Diseases Research Center and National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Department of Immunology, ShahidBeheshti University of Medical Sciences, Tehran, Iran. Ian M Adcock Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK. 2015 10 16 The immunopathology of sarcoidosis remains elusive despite years of research into this multiorgan disease.However, recent studies have provided new insights into the genetics and immune components involved in the clinical manifestation of the disease. Granulomatous inflammation is due to the host immune response to a persistent poorly degradable unknown antigen.Mycobacterium tuberculosis (MTB) is the major disease driver in many patients. The  immune  mechanisms  that  cause this  disease start  with  the  antigenic stimulus, followed by T-cell, macrophage and dendritic cell activation via a classic MHC II–mediated pathway. In addition, the profile of immune mediators reported in sarcoidosis indicates that the inflammasome pathway plays a critical role in disease pathogenesis. Increased understanding of the signal  ransductions pathways involved in the induction of inflammatory processes in sarcoidosis could give rise to new therapeutic approaches in future. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/440 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/440/397

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 5 2014 10 15 307 316 EN Shahram Shahabi Cellular and Molecular Research Center; Urmia University of Medical Sciences, Urmia, Iran AND Department of Microbiology, Immunology and Genetics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Habib Mohammadzadeh Hajipirloo Department of Medical Parasitology and Mycology; Faculty of Medicine;Urmia University of Medical Sciences, Urmia, Iran. Seyed Ahmad Keramati Department of Medical Parasitology and Mycology; Faculty of Medicine;Urmia University of Medical Sciences, Urmia, Iran. Khosrow Hazrati Tappeh Cellular and Molecular Research Center; Urmia University of Medical Sciences, Urmia, Iran AND Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Arezoo Bozorgomid Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 16 We have previously shown the adjuvant activity of propranolol (PRP) (a beta-adrenergic receptor antagonist) using a vaccine model for Salmonella typhimurium. In this study PRP was used as an adjuvant in combination with Plasmodium  berghei  (P. berghei)  whole blood stage (PWBS) antigens. BALB/c mice were immunized three times with a 2-week interval, either PWBS vaccine alone or in combination with the adjuvant alum or propranolol. The control group received phosphate buffered saline. Evaluation of the cellular and humoral immunity was performed by measurement of interferon (IFN)-γ, tumor necrosis factor (TNF)-α, lymphocyte proliferation, total IgG  and IgG2a  in the  control  and  immunized groups. Furthermore, Clinical evaluations were carried out by analyze survival rate and parasitemia of the mice. Our results showed that the mice immunized with propranolol induced higher levels of antibody, IFN-γ and TNF-α as well as stronger lymphocyte proliferative responses compared with other groups. This resulted in improved protective immunity against Plasmodium berghei. Administration of  the  PRP  as an  adjuvant in combination  with the  PWBS Antigen vaccine can shift the immune responses to a T helper1 pattern and enhance the protective immunity. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/439 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/439/398

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 5 2014 10 15 317 323 EN Zeynep Arikan-Ayyildiz Department of Pediatric Allergy and Immunology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. Meral Karaman Department of Experimental Animal Laboratory, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. Fatih Firinci Department of Pediatric Allergy and Immunology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. Muge Kiray Department of Physiology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. Alper Bagriyanik Department of Histology and Embryology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. Osman Yilmaz Department of Experimental Animal Laboratory, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. Nevin Uzuner Department of Pediatric Allergy and Immunology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. Ozkan Karaman Department of Pediatric Allergy and Immunology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. 2015 10 16 Increased arginase activity in the airways decreases L-arginine and causes deficiency of bronchodilating and anti-inflammatory nitric oxide (NO) in asthma. As, it is suggested that L-arginine may have therapeutic potential in asthma treatment, we aimed to investigate the effects of inhaled L-arginine on oxygen saturation (SaO₂) and airway histology in a murine model of acute asthma. Twenty eight BALB/c mice were divided into four groups; I, II, III and IV (control). All groups except the control were sensitized and challenged with ovalbumin. After establishement of acute asthma attack by metacholine administration, the mice were treated with inhaled L-arginine (Group I), saline (Group II) and budesonide (Group III), respectively. SaO₂was measured by pulse oximeter just before and 5 min after methacholine. A third measurement of SaO₂was also obtained 15 min after drug administration in these study groups. Inflammation in the lung tissues of the sacrificed animals were scored to determine the effects of the study drugs. The number of eosinophils in bronchoalveolar lavage (BAL) was determined. The results indicated that inflammatory scores significantly improved in groups receiving study drugs when compared with placebo and L-arginine was similar in decreasing scores when compared with budesonide. SaO₂had a tendency to increase after L-arginine administration after acute asthma attack and this increase was statistically significant (p=0.043). Eosinophilia in BAL significantly reduced in group receiving L-arginine when compared with placebo (p<0.05). Thus in this study we demonstrated that L-arginine improved SaO₂and inflammatory scores in an acute model of asthma. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/438 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/438/399

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 5 2014 10 15 324 334 EN Mohamed Abdel-Aziz Biotechnology Research Unit, Gastro-enterology Center, Mansoura University, Mansoura, Egypt. Ayman Abass Biotechnology Research Unit, Gastro-enterology Center, Mansoura University, Mansoura, Egypt AND King Fahd Medical Research Center, King Abdulaziz University, P.O. Box, 80216 Jeddah 21589 ,Kingdom of Saudi Arabia. Khaled Zalata Pathology Departments ,Faculty of Medicine, Mansoura University, Mansoura, Egypt. Tarek Abd Al-Galel Pediatric Allergy and Immunology Departments ,Faculty of Medicine, Mansoura University, Mansoura, Egypt. Umamma Allam King Fahd Medical Research Center, King Abdulaziz University, P.O. Box, 80216 Jeddah 21589 ,Kingdom of Saudi Arabia. Gamal Karrouf King Fahd Medical Research Center, King Abdulaziz University, P.O. Box, 80216 Jeddah 21589 ,Kingdom of Saudi Arabia AND Department of Surgery, Anesthesiology &amp; Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516 Dakahlia, Egypt. gkarrouf@kau.edu.sa. 2015 10 16 The aim of this study was to investigate the effects of Nigella sativa  (NS) fixed oil in comparison to dexamethasone (Dex) on inducible nitric oxide synthase (iNOS), peripheral blood eosinophils (PBE), allergen specific serum IgG1 and interleukins and airway inflammation in a murine model of allergic asthma. Thirty-one mice were divided into four groups. Group  I (n =  6) served as the control group.   Group   II   (n   =   10)  mice  were  sensitized  intraperitoneally  and   challenged intratracheally with cone albumin with no treatment. Group III(n = 6) mice were sensitized, challenged, and treated with Dex for 17 days starting at 24 hours after the first challenge. Group IV (n = 9) mice were sensitized, challenged, and treated with NS fixed oil for 17 days as well. For all groups, the following procedures were carried out: immunohistochemical study of iNOS in lung tissues, detection of PBE percentage, and histopathological examination of lung tissues for inflammatory cells. Lung tissue iNOS expression increased in sensitized, non-treated mice compared with controls, but this increase was not significant. NS fixed oil treatment significantly reduced PBE and lung inflammation but did not significantly reduce lung tissue iNOS expression compared with the control group. These effects were comparable to the effects of Dex. These   results  suggest  that   Nigella  sativa  exhibits  immunomodulatory   and   anti-inflammatory effect which may be useful for treatment of allergic asthma. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/437 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/437/400

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 5 2014 10 15 335 342 EN Fatemeh Haidari Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Majid Mohammadshahi Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Seyed Hamid Borsi School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Mohammad-Hossein Haghighizadeh School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Shokouh Malgard Department of Nutritional Science, Arvand International Division of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 2015 10 16 Dietary fatty acids play a critical role in modulation of airway inflammation in asthma. This study was conducted to compare dietary intakes of essential fatty acids and serum levels of inflammatory factors in asthmatic and healthy adults, and to examine the potential relationship between inflammatory markers and dietary fatty acids. In this case-control study, 47 asthmatic patients (26 males and 21 females) were compared with 47 controls (24 males and 23 females). Blood samples were taken from case and control groups and tumor necrosis factor-α (TNF-α), high sensitive C-reactive protein (hs-CRP), leptin and adiponectin were determined. Dietary intakes were assessed by semi-quantitative food frequency questionnaire (FFQ). Dietary intakes of omega-3 fatty acids were significantly lower in asthmatic patients compared to controls (p<0.05). Serum concentrations of TNF-α, hs-CRP and leptin were significantly higher in asthmatic patients. There was a significant negative relationship between adiponectin levels and saturated fatty acid intakes in both groups, but the relationship between adiponectin and mono-unsaturated fatty acid intakes was positive and significant only in asthmatic group. No significant correlation between other inflammatory factors and dietary intakes was found in this study. Higher intake of omega-3 and lower levels of inflammatory factors in the healthy control group compared to asthmatic group may explain the protective role of essential fatty acids in asthma. Further studies with larger sample size are needed in this regard. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/436 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/436/401

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 5 2014 10 15 343 347 EN Wei Liu Medicine, Minhang Gumei Community Health Center, Shanghai 201102, China. Jizhi Chu Gumei Community Health Center, Minhang, Shanghai 201102, China. Li Sun Laboratory of the second people's Hospital of Jiaxing 314000, Zhejiang Province, China. Zhiqin Shen Medicine, Minhang Gumei Community Health Center, Shanghai 201102, China. Yan Liu Medicine, Minhang Gumei Community Health Center, Shanghai 201102, China. Qing Peng Department of Respiratory Diseases, Minhang District Central Hospital, Shanghai 201199, China. Xiwen Gao Department of Respiratory Diseases, Minhang District Central Hospital, Shanghai 201199, China. 2015 10 16 This study aimed to identify the relationship between fractional exhaled nitric oxide (FeNO) level and potential factors in non-asthmatic children from Shanghai, China. From March to April 2012, the school-aged children fulfilling the inclusion criteria were recruited. The FeNO levels of non-asthmatic children were detected by the Nano Coulomb nitric oxide analyzer. Questionnaires were recorded, including personal data, family illness history and daily habits. In addition, not only the number of leukocytes and eosinophils but also the level of hemoglobin in peripheral blood, were measured via the automated blood cell analyzer. All data were statistically analyzed with SPSS version 17.0 software and the correlation of these potential factors with FeNO level was calculated via Kendall's rank correlation. A total of 132 healthy children (aging 6-13 years) were enrolled in Minhang District, Shanghai, China. The mean value of FeNO level was 15.05 ppb. The correlation analyses revealed that age (R=0.190, p=0.029) and eosinophil number (R=0.575, p=0.000) were significantly and positively correlated with FeNO levels. The FeNO levels of individuals aged 10-13 years was significantly higher than those of the individuals aged 6-9 years (22.65 ± 18.82 ppb vs. 15.28 ± 9.78 ppb, p<0.05). However, other potential factors were not significantly correlated with FeNO level. The FeNO levels in healthy school-aged children may reflect airway eosinophilic inflammation levels, and was affected by eosinophil count and age significantly. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/435 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/435/402

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 5 2014 10 15 348 355 EN Shokrollah Farrokhi Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran AND The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. Mohammad Kazzem Gheybi The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. Ali Movahhed Department of Biochemistry, Bushehr University of Medical Sciences, Bushehr, Iran. Reyhaneh Dehdari Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Mostafa Gooya The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. Saman Keshvari Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Hossein Gholampour Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Zohreh Mansourian Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Yasaman Khosravi The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. Forough Ghahramani The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. Sahar Zandi Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Razieh Etemadan The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. Rahim Tahmasebi Department of Biostatistics, School of Public Health, Bushehr University of Medical Sciences, Bushehr, Iran. Alireza Reaisi Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Saeed Keshmiri Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Lida Fadaizadeh Lung Transplantation Research Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Reza Masjedi Lung Transplantation Research Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2015 10 16 Asthma and allergic diseases present a major health burden. Information on the prevalence of these diseases indicates that these diseases are increasing in various parts of the world. It was hoped that this study would be helpful to health system policy-makers in planning allergy prevention programs in the region.The prevalence of asthma and allergic diseases and relation between the various risk factors involved were assessed among schoolchildren in the city of Bushehr, Iran. The ISAAC Phase I and III questionnaires were completed by parents of 1280 children aged 6-7 years and self-completed by 1115 students aged 13-14 years.The prevalence of atopic eczema, allergic rhinitis and asthma among 6-7 year-old students were 12.1%, 11.8% and 6.7%, respectively. While, the prevalence of these diseases among 13-14 year-old students were found to be 19%, 30% and 7.6%, respectively. There was an association between asthma and allergic rhinitis as well as eczema (p<0.05). Consumption of fast food as a risk factor was significantly associated with asthma (p=0.03).The prevalence of asthma and allergic diseases was high among schoolchildren in the city of Bushehr, Iran. Also an association was observed between the fast food consumption and asthma. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/434 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/434/403

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 5 2014 10 15 356 363 EN Ebrahim Shakiba Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran. Haidar Tavilani Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran. Mohamad Taghi Goodarzi Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran. Amir Kiani Department of Toxicology and pharmacology, Kermanshah University of Medical Sciences, Kermanshah, Iran AND Molecular Diagnostic Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Tayehbbeh Pourmotabbed Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, U.S.A. Asad Vaisi-Raygani Molecular Diagnostic Research Center, AND Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Kermanshah, Iran. 2015 10 16 Evidences indicate that angiogenesis  is an important process in the development of destructive synovial tissue in rheumatoid  arthritis (RA). Recently, it has been shown that the polymorphism of the integrin-αv subunit encoded by the ITGAV gene plays a role in angiogenesis and is considered  as RA susceptibility loci. This study investigated association of four single nucleotide polymorphisms  (SNPs) in ITGAV with  disease  activity  score (DAS28), serum levels  of  C-reactive protein  (CRP), and  anti-cyclic citrullinated peptide(anti-CCP) antibody in 419 RA patients and 398 healthy individuals. Four SNPs in  ITGAV  gene  (rs3911238, rs3738919, rs10174098 and  rs3768777) were  analyzed.   Serum concentrations of anti-CCP antibody and CRP were measured by ELISA. We used the EULAR activity criteria to calculate DAS28-CRP. Among these SNPs, the ITGAV-rs3911238-G/C polymorphism was associated with RA disease activity  [remission-to-low   and  moderate-to-high  in  codominant   model  (CC vs.GG:  OR=1.53, p=0.041 and allele (C vs. G: OR=1.18, p=0.042)] and presence of anti-CCP (codominant CC vs.GG: OR=2.77, p=0.001,  allele C vs. G:  OR=1.19,p=0.033).  The  carriers  of  CC genotype  ITGAV- rs3911238 had higher serum levels of CRP and anti-CCP antibody titer and higher ESR and disease activity  score than carriers of GG  and CG genotypes. Furthermore, haplotypes  analysis showed that ITGAV rs3733891C/rs3768777T/rs3911238C/rs10174098A and ITGAV rs3733891A/rs3768777T/rs3911238G/rs10174098A haplotypes increased severity and anti-CCP antibody in RA patients (OR=5.54, p=0.049 and OR=2.89;  p=0.024, respectively) in comparison with ITGAV rs3733891C/rs3768777T/rs3911238G/rs10174098A haplotypes. Thus, the present study demonstrated that the link between systemic inflammatory markers and the ITGAV-rs3911238 polymorphism  allele in Iranian RA patients.     https://ijaai.tums.ac.ir/index.php/ijaai/article/view/433 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/433/404

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 5 2014 10 15 364 369 EN Fateme Afkhami Department of Medical Genetic, Medical faculty, Tabriz University of Medical Sciences, Tabriz, Iran AND Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Mahmoud Shekari Khaniani Department of Medical Genetic, Medical faculty, Tabriz University of Medical Sciences, Tabriz, Iran. Layia Farzadi Women Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Zeynab Paknejad Department of Molecular Biology, Basic Sciences faculty, Ahar Islamic Azad University, Ahar, Iran. Sima Mansoori Derakhshan Department of Medical Genetic, Medical faculty, Tabriz University of Medical Sciences, Tabriz, Iran AND Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 2015 10 16 HLA-G is a non-classical HLA class Ib molecule with limited protein variability generated by  alternative  splicing.  HLA-G   displays  immunotolerant   properties  and  hence  plays important roles in the maintenance of a successful pregnancy and maternal tolerance of the semiallogenic fetus. Polymorphism of the HLA-G gene may potentially affect the biological properties of the protein, and a 14-bp insertion/deletion polymorphism in exon 8 of the 3′ untranslated region (3′ UTR) of the HLA-G gene is thought to influence HLA-G expression. To study the association of the 14-bp insertion/deletion (INDEL)  polymorphism with the risk of recurrent spontaneous abortion (RSA), we used polymerase chain reaction (PCR) amplification, and genotyped 85 women in the case group (women who have had two or more unexplained RSA) and 85 women in the control group (women who have had at least one normal pregnancy). Our results showed that the frequencies of the−14 bp/−14 bp and +14 bp/+14 bp genotypes were reduced in women with RSA, while that of the +14 bp/−14 bp genotype was significantly increased in RSA compared with the control group of normal fertile women; no  significant differences in the  allele frequencies of  the  HLA-G  14-bp polymorphism were observed. These results suggest a possible significance of the HLA-G 14-bp INDEL polymorphism in the outcome of pregnancy. However, further studies on other polymorphic sites in the 3 UTR  and  5′  UTR  regions, as well as monitoring  the  serum  HLA-G  concentration  are necessary in order to determine the potential implications of this marker in our population. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/432 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/432/405

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 5 2014 10 15 370 374 EN Seyed Alireza Mahdaviani Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Seyed Amir Mohajerani Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Fakhri Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mazaher Ebrahimi Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Bahram Bashardoost Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Seyed Jafar Razavi Telemedicine Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Masoumeh Toolabi Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Ali Tajik Community medicine department, Tehran University of Medical Science, Tehran, Iran. Soheila Khalilzadeh Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohamad Reza Masjedi Telemedicine Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2015 10 16 The aim of current study is to describe clinical similarities and differences between atopic and non-atopic asthma in children. In a cross-sectional study, 95 asthmatic children (75 allergics and 20 nonallergics) were included in the study. Demographic, clinical, and familial history were compared between two groups. There was no significant differences between variables like sex, age of onset (p=0.75), severity (p=0.70), and family history among the two groups (p=0.42). Patients with allergic asthma were significantly older than those with non- allergic asthma (11.28 ± 3.19 and 9.75 ± 2.35 years, respectively, p=0.02). The controversy lingers over the presence of a completely distinct phenotype of non-atopic asthma in children. Our study suggested that phenotypes of allergic and non-allergic asthma in children were not entirely distinct.   https://ijaai.tums.ac.ir/index.php/ijaai/article/view/431 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/431/406

Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 5 2014 10 15 375 377 EN Neslihan Yerebasmaz Department of Obstetrics and Gynecology, Ankara Etlik Zubeyde Hanim AND Women's Health Teaching and Research Hospital, Ankara, Turkey. Ali Kutlu Department of Allergy and Immunology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey. Ersin Aydin Department of Dermatovenereology, Kasimpasa Military Hospital, Istanbul, Turkey. Ercan Karabacak Department of Dermatovenereology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey. Sami Ozturk Department of Allergy and Immunology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey. Ismet Gun Department of Obstetrics and Gynecology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey. 2015 10 16 Progesterone hypersensitivity (PH) is a rare clinical condition that  displays hypersensitivity to  endogenous  or  exogenous progesterone.  It  is characterized by cyclic dermatologic manifestations at the end of the luteal phase that disappear some days after menses. We present  a  case of  24-year-old woman  showing severe angioedema attacks occurring from the first day of her menstruation and continuing for 4-5 days and having positive progesterone intradermal test (IDT). To our knowledge, there is no case in the literature which is coupled with PH isolated angioedema attacks. In this case report we will discuss diagnostic value of progesterone IDT. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/430 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/430/407