Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 15 5 2016 10 31 413 419 EN Shang Hua Song Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China Xiao Qiang Wang Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China Yang Shen Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China Su Ling Hong Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China Xia Ke Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China 2016 02 27 2016 05 25 Allergic rhinitis (AR) is an IgE-mediated upper airway disease, and its impact on asthma has been widely recognized. Protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and the cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) gene polymorphisms have been reported to be associated with several immune-related diseases. Here we investigated the reffect of these two genes’ polymorphisms on the risk of AR and asthma in Chinese Han children. A total of 106 AR patients, 112 AR with asthma patients, and 109 healthy children were enrolled in the study. The SNPs of PTPN22 (rs2488457, rs1310182, rs3789604) and CTLA-4 (rs3087243, rs11571302, rs11571315, rs231725, rs335219727, and rs4553808) were genotyped using a PCR-restriction fragment length polymorphism assay. For PTPN22, an increased prevalence of the CC genotype and C allele in rs1310182 were identified in AR group. For CTLA-4, AA genotype and A allele in rs3087243 and rs231725 were increased in AR with asthma group while in AR group, AA genotype and A allele in rs231725 were obviously decreased. This study reveals a significant association between SNPs in PTPN22, CTLA-4 gene and AR with asthma in Chinese Han children, which might be susceptibility factors for AR and asthma. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/826 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/826/671