Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 14 6 2015 11 29 642 645 EN Eray Atalay Department of Internal Medicine, Kafkas University Practice and Research Hospital, Kars, Turkey Mehmet Özdemir Department of Internal Medicine, Kafkas University Practice and Research Hospital, Kars, Turkey Gülşen Çiğsar Kafkas University Practice and Reserch Hospital Emergency Department Kars, Turkey Ferhat Omurca Department of Internal Medicine, Kafkas University Practice and Research Hospital, Kars, Turkey Nurullah Aslan Department of Internal Medicine, Kafkas University Practice and Research Hospital, Kars, Turkey Mehmet Yildiz Department of Internal Medicine, Kafkas University Practice and Research Hospital, Kars, Turkey Zehra Gey Medical University of Pleven, Faculty of Medicine Pleven, Bulgaria 2015 11 03 2015 11 03 Angioedema is an asymmetric non-pitting oedema on face, lips, tongue and mucous membranes; any delay in diagnosis and treatment can be fatal. Treatment with lisinopril as an angiotensin converting enzyme (ACE) inhibitor, can be a reason of angioedema. Here we report a case who developed oral-facial edema four years after using lisinopril/hydrochlorothiazide. Laryngeal oedema is a main cause of death in angioedema. The treatment of choice in angioedema including fresh frozen plasma, C1 inhibitor concentrations and BRK-2 antagonists (bradykinin B2 receptor antagonists) were used. In this case; a 77 years old female patient suffering from hypertension was considered. This patient was suffering two days from swelling on her face and neck. Non- allergic angioedema was distinguished in five major forms; acquired (AAO), hereditary (HAE), renin-angiotensin-aldosterone system (RAAS) blocker-dependent, pseudoallergic angioedema (PAS) and an idiopathic angioedema (IAO). She was admitted to our clinic with the diagnosis of hereditary angioedema. Patient had skin edema and life threatening laryngeal edema. In emergency department treatment was started using intravenous methylprednisolone, diphenydramine as well as inhaled and subcutaneous epinephrine simultaneously. Despite the initial treatment, the patient died due to the insufficient respiration and cardiac arrest. The patient has no history of kidney disease. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/649 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/649/584