Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 15 5 2016 10 31 372 380 EN Seyed Mohammad Fathi Children Growth Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Marzieh Tavakol Department of Allergy and Clinical Immunology, Shahid Bahonar Hospital, Alborz University of Medical Sciences, Karaj, Iran Nima Rezaei Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AND Research Center for Primary Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran Masoud Movahedi Department of Allergy and Clinical Immunology, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran Asghar Aghamohammadi Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Mansoureh Shariat Department of Allergy and Clinical Immunology, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran Bamdad Sadeghi Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Nasrin Behniafard Department of Allergy and Clinical Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Behzad Darabi Department of Allergy and Clinical Immunology, Ilam University of Medical Sciences, Ilam, Iran Alireza Hajikhani Faculty of Medicine,Shahid Beheshti University of Medical Sciences, Tehran, Iran Ibrahim Abdollahpour School of Public Health, Arak University of Medical Sciences, Arak, Iran AND Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran Mohammad Gharagozlou Department of Allergy and Clinical Immunology, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran 2015 10 25 2016 06 19 Food allergy is a common disorder especially in the first years of life. Strict avoidance of the responsible food is the most effective therapeutic measure so far. But this continuous vigilance could be stressful for the patient and family and decreases their quality of life (QOL). This survey was designed to evaluate the impact of IgE-mediated food allergy on parental QOL in Iranian patients and to develop a valid Persian version of “Food Allergy Quality Of Life- Parental Burden (FAQL-PB) questionnaire”. 90 patients (28 females, 62 males) and their parents who were referred to the clinic of Allergy in Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran were enrolled. The questionnaire was translated with scientific method and its reliability was approved in a pilot study (ICC=0.75, cronbach-α=0.90). Among all patients the most common allergens were wheat (60%) and cow’s milk (42%). The patient’s age (p=0.02), parent’s gender (p=0.004), mother’s age (p=0.02), duration of the disease (p=0.048), and allergen multiplicity (p=0.004) were found to have the most significant correlation with family and social activity (FSA) domain. The most meaningful associations were achieved between parent’s gender (p<0.001) and emotional issues (EM); as well as meal preparation (MP) with patient’s age (p=0.02), parent’s gender (p<0.0001) and also allergen multiplicity (p= 0.003); likewise nutrition and health concern (NH) domain with parent’s gender (p<0.001). Anaphylaxis’s history did not place any burden on each domain. It was concluded that presence of food allergic patients in families could considerably affect all domains of QOL. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/627 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/627/661