Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 14 6 2015 11 29 552 568 EN Amir Nejad-Moghaddam Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Yunes Panahi Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Meghdad Abdollahpour Alitappeh Department of Immunology, Pasteur Institute of Iran, Tehran, Iran Hojat Borna Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Mohammad Ali Shokrgozar National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran Mostafa Ghanei Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran 2015 10 20 2015 10 20 According to significant improvements in the tissue engineering field over the past several years, lung tissue cells have recently attracted more attention due to the high prevalence and diversity in related diseases. However, selection of an appropriate cell type, screening of suitable conditions for growth and proliferation, as well as subsequent implantation into the body to repair and regenerate damaged tissues are considered as important issues in this context. It should also be noted that most studies have been described in animal models, but not in humans. Because of the high regenerative capacity, predominant immunomodulatory feature, and inhibition of T-lymphocyte proliferation, mesenchymal stem cells (MSCs) may play an important role in the reconstruction of damaged tissues including bronchioles in pulmonary diseases. Interestingly, clinical trial studies demonstrated that MSCs have the significant potential to treat a wide variety of diseases including acute myocardial infarction (AMI), liver cirrhosis, crohn’s disease, and graft-versus-host disease (GVHD). https://ijaai.tums.ac.ir/index.php/ijaai/article/view/610 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/610/578