Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 11 3 2012 09 15 224 229 EN Farnaz Mohajertehran Department of Genetics, Ghaem Hospital, University of Medical Sciences, Mashhad, Iran. Jalil Tavakkol Afshari Department of Immunogenetic & Tissue Culture, Immunology Research Center, Bu Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran Zahra Rezaieyazdi Rheumatic Diseases Research Center, Ghaem Hospital, Faculty of Medicine, University of Medical Sciences, Mashhad, Iran Nayereh Ghomian Women Health Research Center, Imam Reza Hospital, Faculty of Medicine, University of Medical Sciences, Mashhad, Iran 2015 10 16 Pre-eclampsia is a pregnancy-specific syndrome that may be dangerous especially to the fetus. Different cytokines have been found to be elevated in women with pre-eclampsia and may have possible roles in the development of this disorder. Alleles of the interleukin-l-beta (IL-lβ) and tumor necrosis factor alpha (TNF-α) genes are associated with pr-eeclampsia in several studies in different populations. The aim of the present study was to investigate the relationship between IL-lβ (C+3954T) and TNF-α (G-308A) gene polymorphisms with preeclampsia in north east of Iran (Khorasan province).  This study included 54 diagnosed patients with pre-eclampsia and 50 normal pregnant women as control group. DNA was extracted from peripheral blood and the polymorphisms were determined by PCR-RFLP method. Data was analyzed using chi-square and Fisher’s exact tests. There was significant association between TNF-α (G-308A) genotype and pre-eclampsia (p=0.001) but we did not find any significant association between IL-lβ (C+3954T) genotype and pre-eclampsia (p=0.39). The present study might suggest a role for TNF-α in the development of pre-eclampsia; however, IL-lβ (C+3954T) polymorphism could not be considered as a marker of susceptibility to preeclampsia in our population. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/559 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/559/482