Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 11 4 2012 12 15 345 348 EN Sepideh Safaei Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran Mohammad Reza Fazlollahi Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran Masoud Houshmand National Institute of Genetic Engineering Biotechnology Tehran, Iran Amir Ali Hamidieh Hematology oncology & Stem cell Transplantation research center, Tehran University of Medical Sciences, Tehran, Iran Mohammad Hassan Bemanian Department of pediatrics , Division of Allergy and clinical Immunology, Shahid Sadoghi Hospital, Shahid Sadoghi University of Medical Sciences, Yazd, Iran Samin Alavi Department of Pediatric Hematology-Oncology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Farideh Mousavi Department of Pediatrics, Shohada Center Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran Zahra Pourpak Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran Mostafa Moin Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran 2015 10 16 Wiskott-Aldrich syndrome (WAS) is a life-threatening X-linked recessive immunodeficiency disease described as a clinical triad of thrombocytopenia,  eczema, and recurrent infections, caused by mutations of the WAS protein (WASP) gene. The milder form of this disease is X-Linked thrombocytopenia  (XLT) that  presents only as platelet abnormalities. Mutation analysis for 15 boys with Wiskott-Aldrich syndrome was performed. Five previously reported mutations and six novel mutations including G8X, R41X, D283E, P412fsX446, E464X, and AfsX358 were detected. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/541 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/541/509