Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 12 1 2013 03 15 1 17 EN Behzad Yeganeh Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada AND Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada AND Manitoba Institute of Child Heath, University of Manitoba, Winnipeg, Manitoba, Canada Adel Rezaei Moghadam Young Researchers Club, Ardabil Branch, Islamic Azad University, Ardabil, Iran Ahn Thuy Tran Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada Mohammad Niaz Rahim Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada Sudu R Ande Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada Mohammad Hashemi Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Kevin M Coombs Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada AND Manitoba Institute of Child Heath, University of Manitoba, Winnipeg, Manitoba, Canada Saeid Ghavami Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada AND Manitoba Institute of Child Heath, University of Manitoba, Winnipeg, Manitoba, Canada AND St. Boniface Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada 2015 10 16 Asthma is one of the fastest growing syndromes in many countries and is adding a huge cost to the health care system. Increasing reports have linked airway infectious diseases to asthma. Influenza is one of the most serious airway infectious diseases and in recent years there have been some serious influenza virus pandemics which caused increased fatality in numerous different populations. Diverse host response pathways during virus infection have been identified, including different cell death and survival pathways. These pathways include 1) programmed cell death I (apoptosis), 2) programmed cell death II (autophagy), and 3) endoplasmic reticulum stress with subsequent unfolded protein response (UPR). There has been extensive research on the regulatory roles of these pathways during the influenza virus life cycle. These studies address the benefits of enhancing or inhibiting these pathways on viral replication. Here we review the most recent and significant knowledge in this area for possible  benefits  to  clinicians and  basic  scientist researchers  in  different  areas  of  the respiratory and virology sciences. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/539 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/539/463