Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 12 1 2013 03 15 81 85 EN Fatemeh Hajari Taheri Department of Immunology, Hybridoma Lab, Pasteur Institute of Iran, Tehran, Iran AND Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran Maryam Seyedolmohadesin Department of Immunology, Hybridoma Lab, Pasteur Institute of Iran, Tehran, Iran AND Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran Mansour Bayat Department of Medical and Veterinary Mycology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Mehdi Mahdavi Department of Virology, Pasteur Institute of Iran, Tehran, Iran Mohammad Hossein Yazdi Department of Pharmaceutical Biotechnology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Ali Eslamifar Clinical Lab, Pasteur Institute of Iran, Tehran, Iran Mohsen Abolhasani Department of Immunology, Hybridoma Lab, Pasteur Institute of Iran, Tehran, Iran 2015 10 16 Breast cancer  patients  are  susceptible to  infections such  as  candidiasis. Due  to  the importance and the role of matrix metalloproteinases (MMP) in breast cancer progression and its correlation with tumor metastasis, we analyzed the serum level of MMPs -2, -3, -9 and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in breast cancer bearing mice in the presence of systemic Candida albicans infection. Female BALB/c  mice were divided into 4 groups:  group I had tumor  +  candidiasis; group II, tumor only; group III, candidiasis only and group IV as negative control. Tumor tissue was separated from stock breast cancer bearing mice and transplanted subcutaneously into the groups I and II mice. Two weeks after tumor transplantation, groups I and III were infected with Candida albicans by intravenous injection. One week after systemic infection, the sera of the experimental groups were prepared and analyzed with ELISA for MMP-2, -3, -9 and TIMP-1 levels. The results showed that the levels of MMP-3, MMP-9 and TIMP-1 were increased in groups I, II and III, as compared to the control group. However, the level of MMP-2 was decreased in mice infected with Candida albicans and in infected mice bearing tumor. These data suggest that candidiasis may have a positive effect on tumor progression and metastasis. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/530 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/530/474